2014
DOI: 10.1038/tpj.2014.75
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Association study of UGT1A9 promoter polymorphisms with DILI based on systematically regional variation screen in Chinese population

Abstract: Drug-induced liver injury (DILI) is caused by unpredictable adverse drug reaction due mainly to the accumulation of hepatotoxic compounds in the liver resulting in significant damage. Drug-metabolizing enzymes have been prime targets for molecular studies relevant to DILI. The gene UGT1A9 mainly expresses in the liver and has an important role in drug metabolism. The Han Chinese has a very long and complex demographic history, and the population stratification arising from the interplay of different geographic… Show more

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Cited by 8 publications
(5 citation statements)
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“…Over the last decade, polymorphism in UGT1A superfamily has been widely studied, particularly in order to predict interindividual toxicity of irinotecan. 11 Moreover, a recent Chinese study showed an association between UGT1A9 promoter polymorphisms (T>C transition; position -440 [rs2741045]) and DILI, 12 but no pieces of evidence demonstrated so far the functional impact of −118T 9>10 polymorphism on interindividual variation in hepatic UGT1A9 activity and mRNA expression. 13 In the present report, it is of note that both patients presenting with acute hepatic dysfunction exhibited similar polymorphisms (variant -118T 9>10 ) in UGT1A9 gene promoter region.…”
Section: Discussionmentioning
confidence: 99%
“…Over the last decade, polymorphism in UGT1A superfamily has been widely studied, particularly in order to predict interindividual toxicity of irinotecan. 11 Moreover, a recent Chinese study showed an association between UGT1A9 promoter polymorphisms (T>C transition; position -440 [rs2741045]) and DILI, 12 but no pieces of evidence demonstrated so far the functional impact of −118T 9>10 polymorphism on interindividual variation in hepatic UGT1A9 activity and mRNA expression. 13 In the present report, it is of note that both patients presenting with acute hepatic dysfunction exhibited similar polymorphisms (variant -118T 9>10 ) in UGT1A9 gene promoter region.…”
Section: Discussionmentioning
confidence: 99%
“…It mainly exists in the liver and combines with the microparticle membrane to catalyze the glucuronide combination reaction in phase II reaction of liver biotransformation. Several studies have shown that genes UGT1A9 and UGT147 are significantly correlated with DILI ( Jiang et al., 2015 ; Stickel, 2015 ; Terelius, et al., 2016 ). In this study, FFC significantly promoted the expression of ugt2a1, indicating that FFC can affect the phase II response of drug metabolism in liver through ugt2a1, and then affect the function of liver.…”
Section: Discussionmentioning
confidence: 99%
“…All the recruited participants were receiving anti‐TB drug therapy according to the World Health Organization's category I treatment regimen (2HRZE/4HR). The ATLI case recruitment was conducted based on the rigorous criteria of the International Serious Adverse Event Consortium (iSAEC) . ATLI cases were required to meet one of the following criteria:…”
Section: Methodsmentioning
confidence: 99%