Association with Ambient Air Pollutants and School Absence Due to Sickness in Schoolchildren: A Case-Crossover Study in a Provincial Town of Japan

Watanabe, Masanari; Noma, Hisashi; Kurai, Jun; Kato, Kazuhiro; Sano, Hiroyuki

doi:10.3390/ijerph18126631

Cited by 10 publications

(4 citation statements)

References 41 publications

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“…Each additional 10 μg/m 3 was associated with an increased relative risk of 1.28 in Japan (Watanabe et al, 2021), and each additional 1 μg/m 3 increase was associated with a 1.58% increase in the chronic absenteeism rate in the United States (MacNaughton et al, 2017). The effects observed in the present study were comparable, but the levels of particles in the classrooms were lower, and the classrooms had mechanical ventilation and non-operable windows, which significantly reduced the…”

Section: Absence Rates and Particulate Mattersupporting

confidence: 47%

Associations between Illness-Related Absences and Ventilation and Indoor Pm2.5 in Elementary Schools of the Midwestern United States

Deng

Lau²,

Wargocki

et al. 2022

SSRN Journal

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Section: Absence Rates and Particulate Mattersupporting

confidence: 47%

Associations between Illness-Related Absences and Ventilation and Indoor Pm2.5 in Elementary Schools of the Midwestern United States

Deng

Lau²,

Wargocki

et al. 2022

SSRN Journal

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“…Based on data from four ecological time-series studies, one case-crossover study, and one panel study [ 24 , 32 – 36 ], the association between PM 2.5 and school-loss days was significant (RR: 1.0173; 95%CI: 1.0056–1.0290; 80%PI: 0.9951–1.0399; I2: 99%). The majority of studies considered exposure and outcome on the same day or with a lag of one day.…”

Section: Resultsmentioning

confidence: 99%

“…Seven articles analysing the effect of NO 2 were included, five ecological time-series, one cohort study, and one case-crossover study design [ 29 , 31 , 32 , 34 , 36 – 38 ]. As with PM 2.5 , most studies considered exposure and outcome on the same day or with a lag of one day.…”

Section: Resultsmentioning

confidence: 99%

Effects of air pollution on restricted activity days: systematic review and meta-analysis

2023

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Background The adverse effects of air pollution on human health include many diseases and health conditions associated with mortality, morbidity and disability. One example of these outcomes that can be translated into economic costs is the number of days of restricted activity. The aim of this study was to assess the effect of outdoor exposure to particulate matter with an aerodynamic diameter less than or equal to 10 and 2.5 μm (PM10, PM2.5), nitrogen dioxide (NO2), and ozone (O3), on restricted activity days. Methods Observational epidemiological studies with different study designs were included, and pooled relative risks (RR) with 95% confidence intervals (95%CI) were calculated for an increase of 10 μg/m3 of the pollutant of interest. Random-effects models were chosen because of the environmental differences between the studies. Heterogeneity was estimated using prediction intervals (PI) and I-Squared (I2) values, while risk of bias was assessed using a tool developed by the World Health Organization specifically designed for air pollution studies, and based on different domains. Subgroup and sensitivity analyses were performed where possible. The protocol for this review was registered with PROSPERO (CRD42022339607). Results We included 18 articles in the quantitative analysis. Associations between pollutants and restricted activity days in time-series studies of short-term exposures, measured as work-loss days, school-loss days, or both were significant for PM10 (RR: 1.0191; 95%CI: 1.0058–1.0326; 80%PI: 0.9979–1.0408; I2: 71%) and PM2.5 (RR: 1.0166; 95%CI: 1.0050–1.0283; 80%PI: 0.9944–1.0397; I2: 99%), but not for NO2 or O3. Some degree of heterogeneity between studies was observed, but sensitivity analysis showed no differences in the direction of the pooled relative risks when studies with a high risk of bias were excluded. Cross-sectional studies also showed significant associations for PM2.5 and restricted activity days. We could not perform the analysis for long-term exposures because only two studies analysed this type of association. Conclusion Restricted activity days and related outcomes were associated with some of the pollutants under evaluation, as shown in studies with different designs. In some cases, we were able to calculate pooled relative risks that can be used for quantitative modelling.

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“…Asian sand dust (ASD) is considered as an important social problem that threatens human health due to its harmful components [1]. Generally, ASD is called yellow dust or China dust and mainly occurs during spring and autumn in East Asia, including China, Japan, and Korea [2].…”

Section: Introductionmentioning

confidence: 99%

Loranthus tanakae Franch. and Sav. Attenuates Respiratory Inflammation Caused by Asian Sand Dust

Lee,

Pak,

Lee

et al. 2024

Antioxidants

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Asian sand dust (ASD), generally produced in East Asia, including China, Japan, and Korea, directly leads to the development of pulmonary disease and exacerbates underlying pulmonary diseases. Loranthus tanakae Franch. and Sav. is a traditional herbal medicine applied to improve various inflammatory conditions. Here, we evaluated the curative properties of L. tanakae ethanol extract (LTE) against pulmonary inflammation caused by ASD. Additionally, to investigate the mechanism of action of LTE, we performed network pharmacological analysis. ASD was administrated on day 1, 3, and 5 by intranasal instillation, and LTE was orally administered for 6 days. Administration of LTE significantly decreased inflammatory cytokines and the number of inflammatory cells in bronchoalveolar lavage fluid, which was accompanied by a decrease in inflammatory cell accumulation in pulmonary tissue. Administration of LTE decreased the expression of cyclooxygenase2 and matrix metalloproteinase-9 in mice exposed to ASD with the decline in p65 phosphorylation. Additionally, administration of LTE significantly elevated hemeoxygenase (HO)-1 expression in the pulmonary tissue of mice exposed to ASD. These results were consistent with the data of network pharmacological analysis. This experiment showed that LTE attenuated pulmonary inflammation caused by ASD via inhibition of NF-κB and elevation of HO-1. Therefore, LTE may have potential as a therapeutic agent to treat pulmonary inflammation caused by ASD.

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Association with Ambient Air Pollutants and School Absence Due to Sickness in Schoolchildren: A Case-Crossover Study in a Provincial Town of Japan

Cited by 10 publications

References 41 publications

Associations between Illness-Related Absences and Ventilation and Indoor Pm2.5 in Elementary Schools of the Midwestern United States

Associations between Illness-Related Absences and Ventilation and Indoor Pm2.5 in Elementary Schools of the Midwestern United States

Effects of air pollution on restricted activity days: systematic review and meta-analysis

Loranthus tanakae Franch. and Sav. Attenuates Respiratory Inflammation Caused by Asian Sand Dust

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