Associations Among Back and Extremity Pain With Alcohol, Tobacco, and Caffeine Use Among US Air Force Pararescuemen

Bryan, Craig J.; Wolfe, Andrea L.; Morrow, Chad E.; Stephenson, James A.; Haskell, Jeremy; Bryan, Anna Belle O

doi:10.55460/azl6-zqy7

Cited by 3 publications

(7 citation statements)

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“…5,11,16,[59][60][61] Data from our laboratory using the model described in the present study provided evidence in support of these direct effects by demonstrating dose-dependent negative effects on IVD cell viability and ECM composition (decreased GAG content and altered PG: HP ratios) with more rapid and severe changes in injured discs, and this mirrors the findings associated with caffeine exposure in the present study. 2 Caffeine is widely consumed throughout the world with reports of average US consumption rates between 85% and 89% of the population and average daily intake between 165 and 305 mg. 27,35,62 Serum caffeine concentrations for the average US coffee drinker range between 2 and 10 mg/L with abuse of caffeine defined as levels >15 mg/L. 36 The relationship of caffeine with IVD health is not well established and while some studies report correlations between caffeine intake and back pain, others do not.…”

Section: Discussionmentioning

confidence: 99%

“…27 This controversy centers on the fact that caffeine serves to potentiate the effects of analgesics such that patients consuming higher levels of caffeine may be consciously or subconsciously self-medicating, which may confound the results of these studies. 27,64 This potential confounder highlights the need for controlled laboratory studies, such as the present study, in order to delineate and differentiate direct and indirect effects, relationships, and mechanisms for caffeine in IVD health and disease. Interestingly, caffeine shares several physiologic effects with nicotine despite acting through different receptors and pathways.…”

Section: Discussionmentioning

confidence: 99%

“…Caffeine is widely consumed throughout the world with reports of average US consumption rates between 85% and 89% of the population and average daily intake between 165 and 305 mg. 27,35,62 Serum caffeine concentrations for the average US coffee drinker range between 2 and 10 mg/L with abuse of caffeine defined as levels >15 mg/L. 36 The relationship of caffeine with IVD health is not well established and while some studies report correlations between caffeine intake and back pain, others do not.…”

Section: Discussionmentioning

confidence: 99%

“…[24][25][26] While caffeine has not been directly implicated as a risk factor for IVD degeneration, studies have reported an association between caffeine intake and back pain. 27,28 Historically, moderate caffeine consumption has not been associated with proven long-term adverse health effects. However, consumption patterns and caffeine concentrations in beverages and supplements have continued to rise over the past 2 decades such that dependence syndromes have been well described.…”

Section: Introductionmentioning

confidence: 99%

“…[29][30][31][32][33] Importantly, while only 15.5% of US citizens are current smokers, up to 89% of US citizens consume at least one caffeinated beverage daily. 27,34,35 Given the known detrimental effects of nicotine on IVDs and shared physiologic effects of caffeine and nicotine in conjunction with the growing prevalence and amount of caffeine consumption, it is germane to characterize the effects of caffeine on IVD health at the cell and tissue levels in order to understand the potential clinical ramifications with regard to IVD degeneration, pain, and disability. While controlled laboratory studies cannot fully mimic cell and matrix responses that occur in patients, the whole organ rat tail IVD model provides an ethical and valid method for providing initial data for subsequent translational studies.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Caffeine on Intervertebral Disc Cell Viability in a Whole Organ Culture Model

Raines

Stannard

Stricklin

et al. 2020

Global Spine Journal

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Study Design: Controlled laboratory study. Objective: To investigate the impact of exposure to physiologically relevant caffeine concentrations on intervertebral disc (IVD) cell viability and extracellular matrix composition (ECM) in a whole organ culture model as potential contributing mechanisms in development and progression of IVD disorders in humans. Primary outcome measures were IVD viable cell density (VCD) and ECM composition. Methods: A total of 190 IVD whole organ explants from tails of 16 skeletally mature rats—consisting of cranial body half, endplate, IVD, endplate, and caudal body half—were harvested. IVD explants were randomly assigned to 1 of 2 groups: uninjured (n = 90) or injured (20G needle disc puncture/aspiration method, n = 100). Explants from each group were randomly assigned to 1 of 3 treatment groups: low caffeine (LCAF: 5 mg/L), moderate caffeine (MCAF: 10 mg/L), and high caffeine (HCAF: 15 mg/L) concentrations. Results: Cell viability was significantly higher in the low-caffeine group compared with the high-caffeine group at day 7 ( P = .037) and in the low-caffeine group compared with the medium- and high-caffeine groups at day 21 ( P ≤ .004). Analysis of ECM showed that all uninjured and control groups had significantly higher ( P < .05) glycosaminoglycan concentrations compared with all injured groups. Furthermore, we observed a temporal, downward trend in proteoglycan to collagen ratio for the caffeine groups. Conclusions: Caffeine intake may be a risk factor for IVD degeneration, especially in conjunction with disc injury. Mechanisms for caffeine associated disc degeneration may involve cell and ECM, and further studies should elucidate mechanistic pathways and potential benefits for caffeine restriction.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of Caffeine on Intervertebral Disc Cell Viability in a Whole Organ Culture Model

Raines

Stannard

Stricklin

et al. 2020

Global Spine Journal

View full text Add to dashboard Cite

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Association of Chronic Pain With Alcohol Consumption and Tobacco Use in Active Duty Soldiers

Skelly,

Ee,

Dogbey

et al. 2023

Military Medicine

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Introduction Chronic pain and lifestyle habits, namely alcohol consumption and tobacco use, impact soldier readiness. This study examines the relationship between chronic pain and these lifestyle habits in soldiers seen at the Interdisciplinary Pain Management Center (IPMC). Materials and Methods This cross-sectional retrospective review utilized data from active duty soldiers receiving treatment at the IPMC. Soldiers (N = 203, 85% men) treated at the IPMC completed an intake questionnaire that included the Defense and Veterans Pain Rating Scale, the Alcohol Use Disorders Identification Test-Concise, and inquiries about tobacco use. Tobacco use was quantified as the amount and frequency of cigarettes smoked. Other tobacco products were converted to an equivalent number of cigarettes. Data were analyzed using descriptive statistics, Pearson’s correlation, and independent samples t-test analyses. Results The mean duration of pain reported was 34.73 ± 38.66 months (median = 24.00). Soldiers engaging in hazardous drinking reported significantly higher interference with sleep (mean = 6.53 versus 5.40, P = .03) and greater negative effect on mood (mean = 6.33 versus 5.30, P = .04) compared to the no hazardous drinking group. Nonsignificant differences were found between tobacco users and non-tobacco users regarding pain intensity and pain effect on activity, sleep, mood, and stress (all P > .05). Among tobacco users, a significant negative correlation was found between a daily number of cigarettes used and sleep interference (r = −0.29, P = .024) as well as effect on mood (r = −0.33, P = .010). Years of tobacco use showed a significant negative correlation with the average pain intensity (r = −0.32, P = .025). Conclusions The results suggest that addressing alcohol consumption is an essential part of chronic pain treatment. The finding of a negative association between years of nicotine use and pain intensity suggests that nicotine use may have served as a coping mechanism. Further research is needed.

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Lifestyle Medicine for Chronic Lower Back Pain: An Evidence-Based Approach

Altug

2021

American Journal of Lifestyle Medicine

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Lower back pain is a leading cause of work absence and activity limitations globally, with a 60% to 85% lifetime chance of occurrence. This article highlights the role that lifestyle medicine plays in managing lower back pain as a cost-effective intervention strategy. It is suggested that lifestyle medicine strategies, such as incorporating whole foods and a plant-based diet, sustainable physical activity and mind-body exercises, restorative sleep, stress resiliency, awareness and mitigation of substance abuse and addiction, and establishing meaningful social networks and self-care strategies, be a part of managing chronic lower back pain.

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Associations Among Back and Extremity Pain With Alcohol, Tobacco, and Caffeine Use Among US Air Force Pararescuemen

Cited by 3 publications

References 0 publications

Effects of Caffeine on Intervertebral Disc Cell Viability in a Whole Organ Culture Model

Effects of Caffeine on Intervertebral Disc Cell Viability in a Whole Organ Culture Model

Association of Chronic Pain With Alcohol Consumption and Tobacco Use in Active Duty Soldiers

Lifestyle Medicine for Chronic Lower Back Pain: An Evidence-Based Approach

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