Associations among Braak stage, Parkinsonian gait, cognition, and functional status in autopsy‐confirmed dementia with Lewy bodies

Mayo, Ann M.; Peavy, Guerry M.

doi:10.1002/gps.5080

Cited by 3 publications

(2 citation statements)

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“…Lewy body diseases (LBD) refer to a class of syndromes that involve abnormal aggregation of the alpha-synuclein protein (i.e., Lewy bodies) in the brainstem, limbic system, basal ganglia, cortical and olfactory network, and ventral forebrain. This pathology can cause motor symptoms, hallucinations, severe functional impairment, and dementia (Mayo & Peavy, 2019). LBD most commonly refers to dementia with Lewy Bodies (DLB), PD, and PD dementia (PDD), as these conditions share many neuropathological, clinical, and prognostic features (Outeiro et al, 2019).…”

Section: Dementia With Lewy Bodiesmentioning

confidence: 99%

Sex is a defining feature of neuroimaging phenotypes in major brain disorders

Salminen

Tubi

Bright

et al. 2021

Human Brain Mapping

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Sex is a biological variable that contributes to individual variability in brain structure and behavior. Neuroimaging studies of population-based samples have identified normative differences in brain structure between males and females, many of which are exacerbated in psychiatric and neurological conditions. Still, sex differences in MRI outcomes are understudied, particularly in clinical samples with known sex differences in disease risk, prevalence, and expression of clinical symptoms. Here we review the existing literature on sex differences in adult brain structure in normative samples and in 14 distinct psychiatric and neurological disorders. We discuss commonalities and sources of variance in study designs, analysis procedures, disease subtype effects, and the impact of these factors on MRI interpretation. Lastly, we identify key problems in the neuroimaging literature on sex differences and offer potential recommendations to address current barriers and optimize rigor and reproducibility. In particular, we emphasize the importance of large-scale neuroimaging initiatives such as the Enhancing NeuroImaging Genetics through Meta-Analyses consortium, the UK Biobank, Human Connectome Project, and others to provide unprecedented power to evaluate sex-specific phenotypes in major brain diseases.

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Section: Dementia With Lewy Bodiesmentioning

confidence: 99%

Sex is a defining feature of neuroimaging phenotypes in major brain disorders

Salminen

Tubi

Bright

et al. 2021

Human Brain Mapping

View full text Add to dashboard Cite

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Section: Dementia With Lewy Bodiesmentioning

confidence: 99%

Sex is a defining feature of neuroimaging phenotypes in major brain disorders

Salminen¹,

Tubi²,

Bright³

et al. 2020

Preprint

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Sex differences are found in the incidence and expression of psychiatric and neurodegenerative conditions, and many studies suggest these differences are influenced by innate biological differences between males and females and risk factors that interact with these differences. However, few studies have used neuroimaging to examine brain signatures of disease separately by sex, and many studies of sex differences have been based on small samples and their findings have not been replicated in larger cohorts. Large-scale neuroimaging initiatives such as the Enhancing NeuroImaging Genetics through Meta-Analyses (ENIGMA) consortium, the UK Biobank, Human Connectome Project, and others offer an unprecedented source of power to address important questions about the role of sex as a risk or protective factor for suboptimal brain health, as well as sex-specific neuroimaging phenotypes in brain-related illnesses. Here we review the existing neuroimaging literature on sex differences in the human brain in healthy adults and those with the most common and debilitating psychiatric and age-related neurodegenerative conditions. Finally, we discuss key gaps in this literature and opportunities of large-scale collaborative efforts to identify, characterize, and explain how biological sex influences the humanbrain in health and disease.

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