Associations among central nervous, endocrine, and immune activities when positive emotions are elicited by looking at a favorite person

Morikura, Masahiro; Isowa, Tokiko; Kimura, Kenta; Miyakoshi, Makoto; Kanayama, Noriaki; Murakami, Hiroki; Sato, Sayaka; Konagaya, Toshihiro; Nogimori, T; Fukuyama, Seisuke; Shinoda, Jun; Yamada, Jitsuhiro; Ohira, Hideki

doi:10.1016/j.bbi.2007.09.008

Cited by 43 publications

(31 citation statements)

References 42 publications

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“…The social aspect of the training session (the presence of a familiar human) may also have contributed to increased IgA. In humans, looking at a picture of a favorite person can increase IgA (Matsunaga et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Effect of cognitive enrichment on behavior, mucosal immunity and upper respiratory disease of shelter cats rated as frustrated on arrival

Gourkow

Phillips

2016

Preventive Veterinary Medicine

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Please cite this article as: Gourkow, Nadine, Phillips, Clive J.C., Effect of cognitive enrichment on behavior, mucosal immunity and upper respiratory disease of shelter cats rated as frustrated on arrival.Preventive Veterinary Medicine http://dx.doi.org/10. 1016/j.prevetmed.2016.07.012 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Highlights  Regular cognitive enrichment of frustrated cats -a human teaching them a taskimproved their welfare  Treated cats were more content than cats not taught the task  Treated cats had increased concentrations of immunoglobulin A in their feces  Cats that responded well to the treatment had the biggest increase in concentrations of immunoglobulin A in their feces  Treated cats had less respiratory disease 2 ABSTRACT Acquisition of resources and opportunity to engage in natural behaviors has been shown to reduce frustration-related behaviors and enhance health in nondomestic felids kept in zoos, but little is known about whether there are similar effects in domestic cats living in confinement in animal shelters. Fifteen cats rated as Frustrated during the first hour of confinement to a cage at an animal shelter were assigned to either a Treatment (n=7) or Control (n=8) group. Treatment cats were taken from their cages to a separate room four times daily for 10 min each time over a 10 d period, where they took part in training sessions to learn a novel behavior (paw-hand contact with a researcher). Changes in emotional states and mucosal immune response were evaluated over 10 days. Infectious status was determined upon admission and incidence of upper respiratory was determined up to day 40 based on clinical signs. Treated cats were more likely to be rated as Content than Control cats and had greater concentrations of S-IgA (537 µg/g) in feces than Control cats (101 µg/g). Within the Treatment group, cats that responded positively had greater concentrations of S-IgA (925 µg/g) than those that responded negatively (399 µg/g).Control cats were more likely to develop respiratory disease over time compared to cats that received treatment (Hazard Ratio: 2.37, Confidence Interval: 1.35-4.15). It is concluded that there is prima facie evidence that cognitive enrichment of cats exhibiting frustration-related behaviors can elicit positive affect (contentment), stimulate secretion of IgA and reduce incidence of respiratory disease, which is worthy of further study.

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Section: Discussionmentioning

confidence: 99%

Effect of cognitive enrichment on behavior, mucosal immunity and upper respiratory disease of shelter cats rated as frustrated on arrival

Gourkow

Phillips

2016

Preventive Veterinary Medicine

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“…The participants watched the edited control and positive films for the first time at the time of the experiment. The emotional valence of the films had been previously evaluated [7]. The order of the 2 film types was randomized across participants.…”

Section: Task Proceduresmentioning

confidence: 99%

“…The order of the 2 film types was randomized across participants. The detailed PET procedure was described previously [7].…”

Section: Task Proceduresmentioning

confidence: 99%

“…During each film-watching period, the distribution of regional cerebral blood flow (rCBF) was measured using an Advance NXi PET scanner (GE Healthcare Life Sciences, Little Chalfont, England) operating in high-sensitivity 3-dimensional mode [7]. SPM99 software [8] implemented in Matlab (version 6.1; Mathworks, Sherborn, MA) was used for spatial preprocessing and statistical analyses as described previously [7].…”

Section: Image Acquisition By Pet Imagementioning

confidence: 99%

“…SPM99 software [8] implemented in Matlab (version 6.1; Mathworks, Sherborn, MA) was used for spatial preprocessing and statistical analyses as described previously [7]. To clarify significant regional changes within groups (high vs. low) during the positive condition, differences between the 2 groups were analyzed by subtracting the images of the low happiness group from the images of the high happiness group (each obtained by subtracting the control condition images from those obtained during the positive condition).…”

Section: Image Acquisition By Pet Imagementioning

confidence: 99%

See 2 more Smart Citations

Perceived happiness level influences evocation of positive emotions

Morikura

Murakami²,

Yamakawa³

et al. 2011

Self Cite

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Happiness is a positive feeling characterized by satisfaction, joy, pleasure, or love. Perceived happiness level is likely associated with health and well-being. However, the neurobiological mechanisms underlying the positive effects of happiness on psychological and physiological wellness remain obscure. In this study, we found that the medial prefrontal cortex (MPFC) was strongly activated and positive emotions were strongly evoked in individuals with high perceived happiness levels compared to those with low perceived happiness levels when either looked at a favorite person. Moreover, positive mood changes were positively correlated with MPFC activity. These results show that perceived happiness level is associated with positive emotion evocation by means of the MPFC function, which may be involved in psychological and physiological wellness. Therefore, happiness may play an important role in psychological and physiological wellness.

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The Behavioural Dimension of Cancer and Sickness

Cordella¹,

Poiani

2013

Behavioural Oncology

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Associations among central nervous, endocrine, and immune activities when positive emotions are elicited by looking at a favorite person

Cited by 43 publications

References 42 publications

Effect of cognitive enrichment on behavior, mucosal immunity and upper respiratory disease of shelter cats rated as frustrated on arrival

Effect of cognitive enrichment on behavior, mucosal immunity and upper respiratory disease of shelter cats rated as frustrated on arrival

Perceived happiness level influences evocation of positive emotions

The Behavioural Dimension of Cancer and Sickness

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