Associations among dexamethasone non-suppression and TRH-induced hormonal responses: increased specificity for melancholia

Bánki, Csaba M.; Arató, M.; Papp, Zsuzsa; Rihmer, Zoltán; Kovács, Z

doi:10.1016/0306-4530(86)90055-7

Cited by 19 publications

(6 citation statements)

References 25 publications

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“…Some studies reported that melancholic depressive patients showed disturbance of the HPA axis [28,29] , but Nelson and Davis [30] reported a dexamethasone suppression test (DST) nonsuppression rate of 36% in melancholia, also very similar to our whole sample rate of 37.5% in meta-analysis. We tried to compare different types of melancholy in the TRH test and the DEX/CRH test.…”

Section: Dex/crh Testsupporting

confidence: 52%

Enhanced Suppression of Adrenocorticotropic Hormone and Cortisol Responses to Hypothalamic-Pituitary-Adrenal Function and Thyrotropin-Releasing Hormone Tests after Stressful Life Events in Patients with Major Depressive Disorder

Hikichi

Akiyoshi²,

Ichioka³

et al. 2007

Neuropsychobiology

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Background: It is commonly believed that there exists a relationship between the outcome of thyrotropin-releasing hormone (TRH) test, the combined dexamethasone/corticotropin-releasing hormone (DEX/CRH) test and stressful life events (SLEs) in major depressive disorder. Objective: SLEs influence the TRH and DEX/CRH tests in major depressive disorder when administered at the time of admission and improvement. Methods: The TRH and DEX/CRH tests were administered to patients hospitalized for major depressive disorders – on the 4th through the 7th hospital day and at the time of improvement. We measured ΔMAX TSH, ΔMAX ACTH, ACTH AUC, ΔMAX cortisol, cortisol AUC, ΔMAX ACTH/ΔMAX TSH and ΔMAX cortisol/ΔMAX TSH. Results: SLEs were significantly negatively associated with ΔMAX ACTH, ACTH AUC and cortisol AUC at the time of admission. However, these relationships lost significance at the time of improvement. The sample (41 patients at the time of admission, 18 patients at the time of improvement) was relatively small, which may have contributed to false-negative results. Conclusion: SLEs may be negatively associated with the outcome of the DEX/CRH tests in major depressive disorder. The hypothalamic-pituitary-adrenal axis in the DEX/CRH test was modulated by SLEs.

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Section: Dex/crh Testsupporting

confidence: 52%

Enhanced Suppression of Adrenocorticotropic Hormone and Cortisol Responses to Hypothalamic-Pituitary-Adrenal Function and Thyrotropin-Releasing Hormone Tests after Stressful Life Events in Patients with Major Depressive Disorder

Hikichi

Akiyoshi²,

Ichioka³

et al. 2007

Neuropsychobiology

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“…The dexamethasone (DEX) suppression test has been developed in humans to detect HPI axis changes in melancholic patients (Wilens et al 1984;Banki et al 1986;Kumar et al 1986). In humans DEX have shown to reduce the morning peak of cortisol, but more in healthy humans than in depressed patients, and the maximum post-DEX effects on plasma cortisol levels have shown to reflect the overall severity of depression during melancholia (Kumar et al 1986).…”

Section: Discussionmentioning

confidence: 99%

The effect of allostatic load on hypothalamic–pituitary–interrenal (HPI) axis before and after secondary vaccination in Atlantic salmon postsmolts (Salmo salar L.)

Iversen

Eliassen

2013

Fish Physiol Biochem

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The experiment consisted of three experimental groups; 1) "vaccine and stress", 2) "stress and vaccine" and 3) control. All groups have previously been vaccinated 6 months prior to the start of the experiment. At the start of the experiment the "vaccine and stress" group was vaccinated with Pentium Forte Plus for the second time (25.02.2008), and then given a daily stressor (crowding stressor, 267 kg m-3 in 15 min) for a period of four weeks. The "stress and vaccine" group was given a similar daily stressor for four weeks, and then vaccinated for the second time. The control group was neither stressed nor vaccinated a second time. The results indicates that a fish in the "stress and vaccine" group enters an allostatic overload type 2 due to oversensitivity to ACTH, a reduced efficient negative feedback system, with elevated baseline levels of plasma cortisol, and reduced immune response with pronounced effects on the wellbeing of the animal. The "vaccine and stress" group entered an allostatic overload type 1 response, with oversensitivity to ACTH and transient reduced efficient negative feedback system, but at the end of the experiment the fish had recovered. This study shows that if plasma cortisol becomes elevated prior to vaccination it could instigate an allostatic overload type 2 with dire consequences on animal welfare. To reduce the risk of compromising the animal welfare during commercial vaccination of salmon one propose to grade the fish minimum a week prior to vaccination, or grade simultaneously with vaccination. This could reduce the overall allostatic load during handling and vaccination, and secure a healthy fish, with intact immune response and improved animal welfare.3

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“…Recently hospitalized SCH 11/22 (50%) -- Dam et al (1985) SCH inpatients 5/15 (33%) -- Harris (1985) Chronic long stay SCH -4/12 (33%) No association of negative symptoms with NS Herz et al (1985) Recently admitted SCH acutely psychotic 9/13 (69%) 1/5 (20%) of the non-suppressors after 7 days' antipsychotic therapy -- Morphy et al (1985) Admitted SCH patients 6/13 (46%) Saffer et al (1985) Chronic long stay SCH 10/50 (20%) -NS associated with negative symptoms Asnis et al (1986) Chronic and subchronic SCH inpatients 4/17 (24%) -- Banki et al (1986) Recently hospitalized SCH -7/20 (35%) - Cook et al (1986) Acutely admitted SCH 5/25 (20%) -- Doran et al (1986) SCH inpatients -2/13 (15%) No association of NS with depression Hubain et al (1986) Acute, recently admitted SCH 10/22 (45%) -- McMahon et al (1986) Recently admitted, acutely psychotic chronic SCH 1/12 (8%) -- Moller et al (1986) Acutely psychotic SCH 12/20 (60%) day 1 7/19 (37%) day 7 6/12 (46%) day 23 -No association with depressive symptoms. Negative correlation of NS with severity of SCH symptoms Pickar et al (1986) Chronic recently admitted SCH -5/24 (21%) - Sora et al (1986) Recently admitted SCH 7/28 (25%) -- Tsoi et al (1986) Chronic SCH 7/61 (11%) -NS not associated with depression, positive or negative Wik et al (1986) Acutely admitted SCH 4/15 (27%) 17/21 (81%) - Banki et al (1987) Recently hospitalized SCH -6/23 (26%) -Holsboer-Trachsler et al Hwu et al (1987) SCH inpatients 11/60 (18%) -NS associated with depression Joseph et al (1987) Non-depressed acute, chronic and subchronic SCH 0/37 (0%) 2 patients NS but compliance with DEX unclear -- Joyce et al (1987) Recently admitted SCH 2/10 (20%) -- Krishnan et al (1987) Recently admitted SCH 2/15 (13%) -- Pandey et al (1987) Admitted to research unit -4/22 (18%) - Perenyi et al (1987) Recently admitted SCH 6/30 (20%) -No association with anxiety/ depression Zhou et al (1987) Hospitalized SCH 6/48 (13%) -- Aleem et al (1988) SCH inpatients 6/19 (32%) -No association with depression or negative symptoms Coryell et al (1988) Admitted SCH 2/13 (15%) -- Keshavan et al (19...…”

Section: The Dexamethasone Suppression Test In Schizophreniamentioning

confidence: 99%

Review: A systematic review of hypothalamic-pituitary-adrenal axis function in schizophrenia: implications for mortality

2010

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There is convincing evidence that environmental stress plays a significant role in modifying both mental and physical health. The biological mechanisms linking stress to ill health are not fully understood, but significant evidence points to a central role of the stress axes; the hypothalamic–pituitary–adrenal (HPA) axis and the sympathetic nervous system. Together these two systems link the brain and the body and are crucial in maintaining homeostasis as well as improving an organism’s survival chances in the face of environmental challenge. There is evidence of altered HPA axis function in people with a range of mental disorders, and this may in part explain the poor physical health of people with psychotic, mood and anxiety disorders. This paper systematically reviews HPA axis function in people with schizophrenia and relates this to the pattern of physical health seen in this disease. In summary, the evidence suggests people with schizophrenia can experience both hyper- and hypo-function of the HPA axis. It is likely that this contributes to the pattern of poor physical health and premature mortality suffered by people with schizophrenia, in particular the high rates of cardiovascular and metabolic disturbance.

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Associations among dexamethasone non-suppression and TRH-induced hormonal responses: increased specificity for melancholia

Cited by 19 publications

References 25 publications

Enhanced Suppression of Adrenocorticotropic Hormone and Cortisol Responses to Hypothalamic-Pituitary-Adrenal Function and Thyrotropin-Releasing Hormone Tests after Stressful Life Events in Patients with Major Depressive Disorder

Enhanced Suppression of Adrenocorticotropic Hormone and Cortisol Responses to Hypothalamic-Pituitary-Adrenal Function and Thyrotropin-Releasing Hormone Tests after Stressful Life Events in Patients with Major Depressive Disorder

The effect of allostatic load on hypothalamic–pituitary–interrenal (HPI) axis before and after secondary vaccination in Atlantic salmon postsmolts (Salmo salar L.)

Review: A systematic review of hypothalamic-pituitary-adrenal axis function in schizophrenia: implications for mortality

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