Associations Among Fatty Acids, Desaturase and Elongase, and Insulin Resistance in Children

Beccarelli, Lori M.; Scherr, Rachel E.; Newman, John W.; Borkowska, Alison G.; Gray, Ira J.; Linnell, Jessica D.; Keen, Carl L.; Young, Heather M.

doi:10.1080/07315724.2017.1347908

Cited by 11 publications

(9 citation statements)

References 48 publications

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“…In a prevalence study, IR was positive in 28.9% of females and 25.1% of males [15]. In one study, on average, 25% of overweight individuals had insulin resistance; however, in the present study, 52.5% of the total study sample tested positive for IR although our patients had normal body weight [16]. In contrast to previous studies, 73.7% of our patients tested positive for insulin resistance.…”

Section: Discussioncontrasting

confidence: 92%

The effect of insulin resistance on House-Brackmann grade of facial paralysis in patients with Bell’s palsy

Özer¹

2018

Journal of Surgery and Medicine

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How to cite / Atıf için: Özer G. The effect of insulin resistance on the House-Brackmann grade of facial paralysis in patients with Bell's palsy.This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND 4.0) where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. AbstractAim: Bell's palsy is the most common cause of facial nerve lesion and is frequently observed in diabetic patients and the duration of healing is delayed in diabetic patients. To investigate the effect of insulin resistance on the facial paralysis as graded by the House-Brackmann classification in patients with Bell's palsy and to determine the importance of insulin resistance assessed primarily prior to treatment planning. Methods: Patients admitting to our emergency department and outpatient neurology clinic with suspected facial paralysis who were not administered steroid therapy within the first 24 hours were studied. Demographic data were collected for patients with Bell's palsy from different age groups with a normal body mass index (BMI) and no chronic endocrine disease. The House-Brackmann (HB) grading scale was used to assess the clinical severity of the facial paralysis. In addition to routine laboratory tests, fasting insulin level was obtained to estimate HOMA-IR (Homeostatic model assessment for insulin resistance) for all patients. Results: Of 19 patients enrolled, 10 were female (52.6%). Patients had a mean age of 33 years, mean glucose value of 106 mg/dL, mean insulin value of 15.9 µU/mL and mean HOMA-IR value of 4.1. A moderate positive correlation and a statistically significant association were found between mean glucose values and HOMA-IR values (r=0.548; p=0.015) Age and glucose values were not statistically significantly associated with insulin and HOMA-IR values (p=0.858 and p=0.015, respectively). Conclusion: Higher blood glucose and average insulin levels were found in patients with facial nerve paralysis in comparison to general population. Most of the patients were IR-positive. Therefore, assessment of insulin resistance would be beneficial for both treatment planning and taking proactive measures against future development of diabetes in all patients presenting with Bell's palsy. Öz Amaç: Bell's palsi fasial sinir lezyonun en sık nedenidir ve diyabetli hastalarda sık izlenir ve iyileşme süresi diyabetli hastalarda gecikmiştir. Bell's palys geçiren hastalarda insulin resistansının House -Brackman evrelemesi üzerine etkisini araştırmak ve bu araştırma sonucunda Bell' palsi tedavisi planlamadan önce öncelikli olarak insulin direncinin bakılmasının önemini araştırmak. Yöntemler: Çalışmaya fasial paralizi şüphesiyle ilk 24 saat içinde acile veya polikliniğe başvuran ve bu nedenle steroid almamış hastalar dahil edildi. Bell's palys'li hastaların demografik verileri toplanıldı. Endokrin hastalığı olmayan çeşi...

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Section: Discussioncontrasting

confidence: 92%

The effect of insulin resistance on House-Brackmann grade of facial paralysis in patients with Bell’s palsy

Özer¹

2018

Journal of Surgery and Medicine

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“…In one study, on average, 25% of overweight individuals had insulin resistance; however, in the present study, 52.5% of the total study sample tested positive for insulin resistance although our patients had normal body weight [23]. As reported in literature, some children with normal body weight show a higher-than-average HOMA value and the underlying cause of this is not clear.…”

contrasting

confidence: 73%

Do antiepileptics have any potential to induce insulin resistance? A comparison between levetiracetam and valproic acid

Özer

2019

The European Research Journal

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Objective. To explore whether levetiracetam and valproic acid are associated with insulin resistance and to determine their effects on glucose and insulin levels among different age groups. Methods. Demographic data were collected for epileptic patients from different age groups with a normal body mass index and no chronic endocrine disease who were on levetiracetam or valproic acid therapy. In addition to routine laboratory tests, fasting insulin level was checked and Homeostatic Model Assessment for insulin resistance calculated for all patients. Based on these measurements, the effects of levetiracetam and valproic acid on laboratory parameters were compared statistically. Results. A total of 61 patients (30 males, 31 females) diagnosed with epilepsy were included in the study. Thirty-four (55.7%) the patients were less than 15 years of age and the others were older. Twenty-three (37.7%) patients were on valproic acid therapy and 38 (62.3%) patients were receiving levetiracetam. Thirty-two (52.5%) the patients tested positive for insulin resistance and others were insulin resistance-negative. Nine (28.1%) patients on valproic acid treatment and 71.9% (n = 23) of patients on levetiracetam treatment were insulin resistance-positive. Conclusions. In the present study, contrary to the published literature, levetiracetam was found to be associated with further negative effects on insulin and blood glucose metabolism compared to valproic acid. We determined that levetiracetam had a distinct pharmacokinetic profile in pediatric patients as demonstrated by its effects on glucose and insulin metabolism.Eur Res J 2018

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“…SCD-1 was supposed to protect against the harmful effects of saturated FA accumulation in tissues and bloodstream by metabolizing them into monounsaturated FA [24]. Anyhow, animal models showed an unfavorable association with cardiovascular risk factors [25,26] Although the role of SCD-1 in humans is not completely understood, several studies reported its unfavorable association with cardiometabolic profile, in particular with BP [27], obesity [28] and insulin sensitivity [29], even in children [30]. Also, our results show higher SCD-16 activity in the excess-weight group and direct associations among the desaturase activity and several CV risk factors, which were stronger in overweight/obese than in normal-weight children.…”

Section: Discussionmentioning

confidence: 99%

Fatty Acid Profile and Desaturase Activities in 7–10-Year-Old Children Attending Primary School in Verona South District: Association between Palmitoleic Acid, SCD-16, Indices of Adiposity, and Blood Pressure

Bonafini

Giontella

Tagetti

et al. 2020

IJMS

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In previous studies, dietary and circulating fatty acids (FA) and desaturases activity (delta-5 desaturase [D5D], delta-6 desaturase [D6D], and stearoyl-CoA desaturase [SCD-16]) involved in their metabolism were associated with metabolic and cardiovascular disorders. The aim of the study was to assess the association between different FAs and desaturases activity (estimated as product:precursor ratios) with individual cardiovascular risk factors (in particular, anthropometric measurements and blood pressure [BP]) in children. The FA profile was determined on a whole-blood drop in 243 children (age: 8.6 ± 0.72 years) participating in a school-based cross-sectional study. Docosahexaenoic acid (DHA) inversely correlated with indices of adiposity, glucose, and triglycerides. Palmitoleic acid and SCD-16 were directly associated with markers of adiposity and BP, even after adjustment for main confounders. D6D correlated directly with the waist/height ratio. Children with excess weight (>85th percentile; that is overweight plus obese ones) showed higher palmitic acid, palmitoleic acid, and higher SCD-16 activity as compared to normal-weight children. Most of the associations were confirmed in the excess-weight group. Omega-3 FAs, particularly DHA, but not omega-6 FA, showed a potentially beneficial association with metabolic parameters, whereas palmitoleic acid and SCD-16 showed a potentially harmful association with indices of adiposity and BP, especially in obese children.

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Associations Among Fatty Acids, Desaturase and Elongase, and Insulin Resistance in Children

Abstract: There was no relationship between these lipid markers and adiposity in this population; however, there were correlations with HOMA-IR. Regardless of adiposity, there may be underlying changes in fatty acid and lipid metabolism associated with the development of metabolic diseases.

Cited by 11 publications

References 48 publications

The effect of insulin resistance on House-Brackmann grade of facial paralysis in patients with Bell’s palsy

The effect of insulin resistance on House-Brackmann grade of facial paralysis in patients with Bell’s palsy

Do antiepileptics have any potential to induce insulin resistance? A comparison between levetiracetam and valproic acid

Fatty Acid Profile and Desaturase Activities in 7–10-Year-Old Children Attending Primary School in Verona South District: Association between Palmitoleic Acid, SCD-16, Indices of Adiposity, and Blood Pressure

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