Associations among the Degree of Nonalcoholic Fatty Liver Disease, Metabolic Syndrome, Degree of Obesity in Children, and Parental Obesity

Oh, M. Kim; Kim, Sorina; Jang, Joon-Hyuck; Park, Jong Yoon; Kang, Hyun-Sik; Lee, Mu Sook; Kang, Kyu-Suk

doi:10.5223/pghn.2016.19.3.199

Cited by 17 publications

(13 citation statements)

References 23 publications

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“…We speculate that obesity stimulates the second hit because of fibrosis since leptin may be an important link between obesity and fibrosis. Oh, et al29 also showed that the degree of NAFLD correlated with the degree of obesity. Obesity was shown to be required for the development of liver fibrosis in a steatohepatitis model 30…”

Section: Discussionmentioning

confidence: 95%

Pathologic Impact of Insulin Resistance and Sensitivity on the Severity of Liver Histopathology in Pediatric Non-Alcoholic Steatohepatitis

et al. 2017

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PurposeInsulin resistance (IR) has an important role in the development of non-alcoholic steatohepatitis (NASH). We aimed to analyze the association between liver histopathology and IR in pediatric patients with NASH.Materials and MethodsIn 24 children with non-alcoholic fatty liver disease (NAFLD), we investigated whether the hepatic pathologic characteristics have relations with following three biochemical indices; IR index including homeostasis model assessment of IR (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), and insulin sensitivity indices-free fatty acid (ISI-FFA).ResultsAmong 24 patients, 16 (66.6%) had a high NAFLD activity score (NAS), which is diagnostic of NASH. Higher serum triglyceride level was significantly correlated with a high NAS. Higher steatosis grades were significantly associated with low insulin sensitivity (p=0.023). In addition, severe lobular inflammation was associated with higher IR: HOMA-IR (p=0.014) and QUICKI (p=0.023). Severe fibrosis correlated with low insulin sensitivity and high IR indexes: ISI-FFA (p=0.049), HOMA-IR (p=0.028), and QUICKI (p=0.007).ConclusionPatients with high IR had more severe lobular inflammation and hepatic fibrosis. Analyses of biochemical and endocrine parameters can be applied to determine the severity of the hepatic pathologic status in patients with NASH, especially in children who cannot undergo a liver biopsy.

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Section: Discussionmentioning

confidence: 95%

Pathologic Impact of Insulin Resistance and Sensitivity on the Severity of Liver Histopathology in Pediatric Non-Alcoholic Steatohepatitis

et al. 2017

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“…However, ultrasonographic examination is widely used to screen NAFLD in epidemiological research as it is non-invasive, safe, widely available and portable, and the sensitivity and specificity for detecting hepatic steatosis is acceptable; Second, the assessment of NAFLD degree was conducted by ultrasound, which might induce subjectivity and inconsistency. Although ultrasound might not be the golden standard evaluator for NAFLD degree, liver ultrasonography is a noninvasive method which is most commonly used to evaluate the degree of steatosis for NAFLD in the practice [ 39 ]. To reduce the subjectivity and improve the consistency between the assessments of ultrasound physicians, all experienced physicians involved in our study were well-trained.…”

Section: Discussionmentioning

confidence: 99%

Joint associations of serum uric acid and ALT with NAFLD in elderly men and women: a Chinese cross-sectional study

et al. 2018

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BackgroundEpidemiological evidence suggests sex difference in serum uric acid (SUA) and alanine aminotransferase (ALT) might be a potential explanation for the gender difference in prevalence of non-alcoholic fatty liver disease (NAFLD). However, few epidemiology data in China have tested this hypothesis.MethodsWe conducted a cross-sectional study to assess the joint associations between SUA and serum ALT with NAFLD among elderly Chinese men and women.ResultsAmong 7569 participants with a mean age of 59.8 years (± 13.4 years), 56.6% of women and 43.4% of men were diagnosed as NAFLD, respectively. A positive association between SUA and NAFLD prevalence was observed in both men and women. NAFLD prevalence was 2.74 times (95% CI 2.00–3.76) higher for men and 4.60 times (95% CI 3.39–6.24) higher for women with the highest quintiles of SUA levels compared to those with the lowest levels. SUA levels were significantly associated with prevalence of mild- and severe-steatosis (P < 0.01). In addition, the ORs of NAFLD among participants with high SUA levels and high serum ALT was 10.75 (95% CI 3.56–32.46) for men and 7.96 (95% CI 2.83–22.39) for women, compared with those with low SUA levels and low serum ALT.ConclusionsSUA levels were positively associated with NAFLD prevalence, and the association was slightly stronger in women than in men. A significant joint association of SUA and serum ALT with NAFLD prevalence was observed in all participants, which was slightly stronger in men than in women.

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“…However, PC:PE ratios that are higher than normal have also been shown to be associated with NAFLD. We have previously observed increased hepatic PEMT activity and PC:PE molar ratio in diabetic rats (25). In addition, glycine N-methyltransferase-deficient mice display increased PC synthesis through the PEMT pathway and, consequently, have a dramatically increased hepatic PC:PE molar ratio (26).…”

Section: Disparities In the Effects Of Pemt Deficiency In Different Mmentioning

confidence: 94%

Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance

Wan¹,

Veen²,

N'Goma³

et al. 2019

FASEB j.

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Phosphatidylethanolamine (PE) N‐methyltransferase (PEMT) accounts for ∼30% of hepatic phosphatidylcholine (PC) biosynthesis. Pemt−/− mice fed a high‐fat diet are protected against diet‐induced obesity (DIO) and insulin resistance (IR) but develop nonalcoholic fatty liver disease (NAFLD) associated with a decreased POPE ratio. We investigated whether the lack of hepatic PEMT or the lack of PEMT in other tissues (where it is expressed at low levels) is responsible for or contributes to the protection against DIO and IR in Pemt−/− mice. Furthermore, we investigated whether decreasing PEMT expression with antisense oligonucleotides (ASOs) would result in metabolic benefits in both lean and obese mice without negatively impacting liver health. We both restored hepatic PEMT in Pemt−/− mice via adeno‐associated virus delivery and decreased hepatic PEMT with ASOs in wild‐type and ob/ob mice. Weight gain, insulin sensitivity, and indices of liver function were determined. We report that the protection against DIO and IR and the development of NAFLD is dependent on hepatic PEMT activity. NAFLD, associated with a significant decrease in the hepatic PC:PE ratio, was exacerbated by PEMT deficiency in obese mice, suggesting that phospholipid insufficiency promotes NAFLD progression during obesity or overnutrition. Hepatic PEMT is critical for maintaining phospholipid balance, which is crucial for a healthy liver.—Wan, S., van der Veen, J. N., Bakala N'Goma, J.‐C., Nelson, R. C., Vance, D. E., Jacobs, R. L. Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance. FASEB J. 33, 10986–10995 (2019). http://www.fasebj.org

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Associations among the Degree of Nonalcoholic Fatty Liver Disease, Metabolic Syndrome, Degree of Obesity in Children, and Parental Obesity

Cited by 17 publications

References 23 publications

Pathologic Impact of Insulin Resistance and Sensitivity on the Severity of Liver Histopathology in Pediatric Non-Alcoholic Steatohepatitis

Pathologic Impact of Insulin Resistance and Sensitivity on the Severity of Liver Histopathology in Pediatric Non-Alcoholic Steatohepatitis

Joint associations of serum uric acid and ALT with NAFLD in elderly men and women: a Chinese cross-sectional study

Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance

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