Associations among types of impulsivity, substance use problems and Neurexin-3 polymorphisms

Stoltenberg, Scott F.; Lehmann, Melissa K.; Christ, Christa C.; Hersrud, Samantha L.; Davies, Gareth E.

doi:10.1016/j.drugalcdep.2011.05.025

Cited by 34 publications

(36 citation statements)

References 38 publications

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“…Self-reported anxiety symptoms and impulsivity were also examined given their association with SUP (Marmorstein et al, 2010; Petry, 2001; Stoltenberg et al, 2011). Anxiety symptoms were measured using the Beck Anxiety Inventory (BAI; Beck et al, 1988).…”

Section: Methodsmentioning

confidence: 99%

The interacting effect of depressive symptoms, gender, and distress tolerance on substance use problems among residential treatment-seeking substance users

Ali¹,

Seitz-Brown²,

Daughters³

2015

Drug and Alcohol Dependence

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Background Depression is associated with substance use problems; however, the specific individual characteristics influencing this association are not well identified. Empirical evidence and theory suggest that gender and distress tolerance—defined behaviorally as an individual’s ability to persist in goal-directed behavior while experiencing negative affective states—are important underlying factors in this relationship. Hence, the purpose of the current study was to examine whether gender and distress tolerance moderate the relationship between depressive symptoms and substance use problems. Methods Participants included 189 substance users recruited from a residential substance abuse treatment center. The Short Inventory of Problems-Alcohol and Drugs scale was used to measure self-reported substance use problems. The Beck Depression Inventory was used to assess self-reported depressive symptoms. Gender was self-reported, and distress tolerance was behaviorally indexed by the Computerized Paced Auditory Serial Addition Task. Results Hierarchical linear regression analysis indicated a significant three-way interaction of depressive symptoms, gender, and distress tolerance on substance use problems, adjusting for relevant demographic variables, anxiety symptoms, impulsivity, as well as DSM-IV psychiatric disorders. Probing of this three-way interaction demonstrated a significant positive association between depressive symptoms and substance use problems among females with low distress tolerance. Conclusion Findings indicate that female treatment-seeking substance users with high levels of depressive symptoms exhibit greater substance use problems if they also evidence low distress tolerance. Study implications are discussed, including the development of prevention and intervention programs that target distress tolerance skills.

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Section: Methodsmentioning

confidence: 99%

The interacting effect of depressive symptoms, gender, and distress tolerance on substance use problems among residential treatment-seeking substance users

Ali¹,

Seitz-Brown²,

Daughters³

2015

Drug and Alcohol Dependence

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“…They are hypothesized to mediate impulsivity and therefore may be implicated in genetic vulnerability for opioid dependence [92]. In a genome-wide study, Lachman et al [93] found an association between opioid dependence and a wide region of chromosome 14q (exclusive to the Puerto Rican subpopulation) where the NRXN3 gene is located.…”

Section: Genetic Susceptibility To Opioid Dependencementioning

confidence: 99%

Genetics of Opioid Dependence: A Review of the Genetic Contribution to Opioid Dependence

Mistry

Bawor

Desai

et al. 2014

CPSR

119

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This narrative review aims to provide an overview of the impact of opioid dependence and the contribution of genetics to opioid dependence. Epidemiological data demonstrate that opioid dependence is a global trend with far-reaching effects on the social, economic, and health care systems. A review of classical genetic studies of opioid use suggests significant heritability of drug use behavior, however the evidence from molecular genetic studies is inconclusive. Nonetheless, certain genetic variants are important to consider given their role in the pathophysiology of addictive behavior. We undertook a literature review to identify the current state of knowledge regarding the role of genes in opioid dependence. Determining the association of genetic markers could change the current understanding of the various factors contributing to opioid dependence and therefore may improve recognition of individuals at risk for the disorder and prevention and treatment strategies.

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“…Specific biological (e.g., genetic) factors may contribute to these gender-related differences (Stoltenberg et al, 2011). Gender-related differences also exist with respect to casual sexual behaviors, observed more frequently amongst men than women (Garcia et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Gender-related differences in the associations between sexual impulsivity and psychiatric disorders

Erez

Pilver

Potenza

2014

Journal of Psychiatric Research

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Objective Sexual impulsivity (SI) has been associated with conditions that have substantial public health costs, such as sexually transmitted infections and unwanted pregnancies. However, SI has not been examined systematically with respect to its relationships to psychopathology. We aimed to investigate associations between SI and psychopathology, including gender-related differences. Method We performed a secondary data analysis of Wave-2 of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), a national sample of 34,653 adults in the United States. DSM-IV-based diagnoses of mood, anxiety, drug and personality disorders were assessed using the Alcohol Use Disorder and Associated Disabilities Interview Scheduled DSM-IV Version. Results The prevalence of SI was considerable (14.7%), with greater acknowledgment by men than women (18.9% versus 10.9%; p<0.0001). For both women and men, SI was positively associated with most Axis-I and Axis-II psychiatric disorders (OR range: Women, Axis-I:1.89-6.14, Axis-II:2.10-10.02; Men, Axis-I:1.92-6.21, Axis-II:1.63-6.05). Significant gender-related differences were observed. Among women as compared to men, SI was more strongly associated with social phobia, alcohol abuse/dependence, and paranoid, schizotypal, antisocial, borderline, narcissistic, avoidant and obsessive-compulsive personality disorders. Conclusion The robust associations between SI and psychopathology across genders suggest the need for screening and interventions related to SI for individuals with psychiatric concerns. The stronger associations between SI and psychopathology among women as compared to men emphasize the importance of a gender-oriented perspective in targeting SI. Longitudinal studies are needed to determine the extent to SI predates, postdates or co-occurs with specific psychiatric conditions.

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Associations among types of impulsivity, substance use problems and Neurexin-3 polymorphisms

Cited by 34 publications

References 38 publications

The interacting effect of depressive symptoms, gender, and distress tolerance on substance use problems among residential treatment-seeking substance users

The interacting effect of depressive symptoms, gender, and distress tolerance on substance use problems among residential treatment-seeking substance users

Genetics of Opioid Dependence: A Review of the Genetic Contribution to Opioid Dependence

Gender-related differences in the associations between sexual impulsivity and psychiatric disorders

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