Associations between anterior cingulate thickness, cingulum bundle microstructure, melancholia and depression severity in unipolar depression

Mertse, Nicolas; Denier, Niklaus; Walther, Sebastian; Breit, Sigrid; Grosskurth, Elmar D.; Federspiel, Andrea; Wiest, Roland; Bracht, Tobias

doi:10.1016/j.jad.2022.01.035

Cited by 25 publications

(15 citation statements)

References 72 publications

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“…Patients of this observational study were recruited at the University Hospital of Psychiatry and Psychotherapy in Bern, Switzerland and includes participants of previous reports of cross-sectional data [ 14 , 17 , 34 ]. We recruited two patient groups with a current depressive episode (ECT-group, and TAU-group) and a HC group (for study flow see Supplementary Material, S1 ).…”

Section: Methodsmentioning

confidence: 99%

“…One of the most replicated findings is an ECT-induced volume increase in the hippocampi and the amygdalae [ 7 , 10 , 11 ], which may reverse depression pathophysiology linked to these limbic structures [ 12 – 14 ] and to extended networks [ 15 – 17 ]. However, studies investigating correlations between hippocampal and amygdalar enlargements during ECT and clinical improvements led to conflicting results [ 18 – 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Distinct and shared patterns of brain plasticity during electroconvulsive therapy and treatment as usual in depression: an observational multimodal MRI-study

et al. 2023

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Electroconvulsive therapy (ECT) is a highly effective treatment for depression. Previous studies point to ECT-induced volume increase in the hippocampi and amygdalae, and to increase in cortical thickness. However, it is unclear if these neuroplastic changes are associated with treatment response. This observational study aimed to address this research question by comparing neuroplasticity between patients with depression receiving ECT and patients with depression that respond to treatment as usual (TAU-responders). Twenty ECT-patients (16 major depressive disorder (MDD), 4 depressed bipolar disorder), 20 TAU-responders (20 MDD) and 20 healthy controls (HC) were scanned twice with multimodal magnetic resonance imaging (structure: MP2RAGE; perfusion: arterial spin labeling). ECT-patients were scanned before and after an ECT-index series (ECT-group). TAU-responders were scanned during a depressive episode and following remission or treatment response. Volumes and cerebral blood flow (CBF) of the hippocampi and amygdalae, and global mean cortical thickness were compared between groups. There was a significant group × time interaction for hippocampal and amygdalar volumes, CBF in the hippocampi and global mean cortical thickness. Hippocampal and amygdalar enlargements and CBF increase in the hippocampi were observed in the ECT-group but neither in TAU-responders nor in HC. Increase in global mean cortical thickness was observed in the ECT-group and in TAU-responders but not in HC. The co-occurrence of increase in global mean cortical thickness in both TAU-responders and in ECT-patients may point to a shared mechanism of antidepressant response. This was not the case for subcortical volume and CBF increase.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Distinct and shared patterns of brain plasticity during electroconvulsive therapy and treatment as usual in depression: an observational multimodal MRI-study

et al. 2023

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“…Depression as well as schizophrenia go along with significant ( Shah et al, 2017 ; Brandl et al, 2019 ; Hellewell et al, 2019 ; Huang et al, 2021 ; Liloia et al, 2021 ; Serra-Blasco et al, 2021 ; Gutman et al, 2022 ), progressive ( Vita et al, 2012 ) transdiagnostic ( Goodkind et al, 2015 ) as well as diagnosis and symptom specific ( Horn et al, 2010 ; Stegmayer et al, 2014 , 2016 ; Walther et al, 2017 ; Viher et al, 2018 ; Kindler et al, 2019 ; Schoretsanitis et al, 2019 ; Dean et al, 2020 ; Mertse et al, 2022 ) patterns of gray matter loss which may represent a hallmark of both disorders. Given the evidence for winter– and spring-birth excesses for schizophrenia, and major depression, and, as already mentioned, the suggested link with neurodevelopmental abnormalities, the question arises as to whether this seasonal birth pattern is associated with alterations in the brain.…”

Section: Introductionmentioning

confidence: 99%

Effect of Season of Birth on Hippocampus Volume in a Transdiagnostic Sample of Patients With Depression and Schizophrenia

Schaub¹,

Ammann²,

Conring³

et al. 2022

Front. Hum. Neurosci.

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Psychiatric disorders share an excess of seasonal birth in winter and spring, suggesting an increase of neurodevelopmental risks. Evidence suggests season of birth can serve as a proxy of harmful environmental factors. Given that prenatal exposure of these factors may trigger pathologic processes in the neurodevelopment, they may consequently lead to brain volume alterations. Here we tested the effects of season of birth on gray matter volume in a transdiagnostic sample of patients with schizophrenia and depression compared to healthy controls (n = 192). We found a significant effect of season of birth on gray matter volume with reduced right hippocampal volume in summer-born compared to winter-born patients with depression. In addition, the volume of the right hippocampus was reduced independent from season of birth in schizophrenia. Our results support the potential impact of season of birth on hippocampal volume in depression.

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“…Specifically, structural connectivity in cingulum and functional connectivity in cerebellum, thalamus, PFC, and pre/post-central gyri. There is ample evidence of these regions' involvement in both depression and fatigue (109,110,131,171,200,226,227). Both depression and fatigue were associated with connectivity changes in the cortico-limbic network, and especially the fronto-limbic network.…”

Section: Overlapping Brain Connectivity Changes Associated With Depre...mentioning

confidence: 99%

Brain connectivity changes underlying depression and fatigue in relapsing-remitting multiple sclerosis: a systematic review

Kampaite

Gustafsson

York

et al. 2022

Preprint

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Fatigue and depression are common, debilitating, and intertwined symptoms in people with relapsing-remitting multiple sclerosis (pwRRMS). To elucidate the relationship between depression/fatigue and brain connectivity in pwRRMS we conducted a systematic review. Searched databases were PubMed, Web-of-Science and Scopus. Inclusion criteria were: participants with RRMS; published between 2001-2021; fatigue and depression assessments validated for MS; brain structural, functional (fMRI) or diffusion MRI (dMRI). 16 dMRI (13 fatigue, 4 depression) and 18 fMRI (16 fatigue, 4 depression) studies were included. ~50% of studies reported no correlation between MRI measures and fatigue/depression. Positive findings showed that abnormal cortico-limbic structural and functional connectivity was associated with depression, and fatigue was linked to connectivity measures in cortico-thalamic-basal-ganglial networks. Additionally, both depression and fatigue were related to altered cingulum structural connectivity, and functional connectivity involving thalamus, cerebellum, frontal lobe, and pre-/postcentral gyri. These findings suggest neuropathological effects in these regions may underlie fatigue and depression in pwRRMS, but the overall results were inconclusive. Further studies using optimised imaging protocols and validated depression and fatigue measures are required to clarify the substrate underlying these symptoms in pwRRMS.

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Associations between anterior cingulate thickness, cingulum bundle microstructure, melancholia and depression severity in unipolar depression

Cited by 25 publications

References 72 publications

Distinct and shared patterns of brain plasticity during electroconvulsive therapy and treatment as usual in depression: an observational multimodal MRI-study

Distinct and shared patterns of brain plasticity during electroconvulsive therapy and treatment as usual in depression: an observational multimodal MRI-study

Effect of Season of Birth on Hippocampus Volume in a Transdiagnostic Sample of Patients With Depression and Schizophrenia

Brain connectivity changes underlying depression and fatigue in relapsing-remitting multiple sclerosis: a systematic review

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