Associations between arsenic in drinking water and the progression of chronic kidney disease: A nationwide study in Taiwan

Cheng, Ya-Yun; Huang, Ning; Chang, Yu Tzu; Sung, Junne Ming; Shen, Kun Hung; Tsai, Chang Chih; Guo, How‐Ran

doi:10.1016/j.jhazmat.2016.09.032

Cited by 69 publications

(29 citation statements)

References 47 publications

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“…Even low arsenite concentrations (0.002-0.025 mg L −1 ) in drinking water might increase the risk of myocardial infarction [7] and affect the female fecundity [8]. Cheng et al found a relation between exposure to arsenic and chronic kidney disease in Taiwan [9]. According to recent reports the arsenite toxicity is due to its interaction to cysteine residues in proteins [10].…”

Section: Introductionmentioning

confidence: 99%

Adsorption of Aqueous As (III) in Presence of Coexisting Ions by a Green Fe-Modified W Zeolite

Medina-Ramírez

Gamero‐Melo²,

Ruiz-Camacho

et al. 2019

Water

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The high toxicity of arsenite and the difficulty to remove it is one of the main challenges for water treatment. In the present work the surface of a low cost zeolite was modified by chemical treatment with a ferrous chloride to enhance its arsenite adsorption capacity. The effect of pH, ions coexistence, concentration, temperature and dosage was studied on the adsorption process. Additionally, the Fe-modified W zeolite was aged by an accelerated procedure and the regeneration of the exhausted zeolite was demonstrated. The Fe-modified W zeolite was stable in the pH range of 3 to 8 and no detriment to its arsenite removal capacity was observed in the presence of coexisting ions commonly found in underground water. The studies showed that the adsorption of As (III) on Fe-modified W zeolite is a feasible, spontaneous and endothermic process and it takes place by chemical bonding. The exhausting process proved the adsorption of 0.20 mg g−1 of As (III) by the Fe-modified W zeolite and this withstand at least five aging cycles without significant changes of its arsenite adsorption capacity. Fe-modified W zeolite prepared from fly ash might be a green and low-cost alternative for removal of As (III) from groundwater.

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Section: Introductionmentioning

confidence: 99%

Adsorption of Aqueous As (III) in Presence of Coexisting Ions by a Green Fe-Modified W Zeolite

Medina-Ramírez

Gamero‐Melo²,

Ruiz-Camacho

et al. 2019

Water

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“…In diabetes, outcomes such as microvascular (nephropathy, retinopathy and neuropathy eventually leading to blindness) and macrovascular (cardiac, cerebral and peripheral) changes are collectively known as diabetic complications because they occur more commonly in people with rather than without diabetes. However, CAsE itself can adversely impact the kidney function in diabetic patients independently from blood glucose levels (Robles‐Osorio et al, ; Wang et al, ), and arsenic can aggravate CKD independently of other factors (Cheng et al, ).…”

Section: Discussionmentioning

confidence: 99%

Chronic arsenic intoxication diagnostic score (CAsIDS)

Dani

Walter

2017

J of Applied Toxicology

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Arsenic and its compounds are well-established, potent, environmentally widespread and persistent toxicants with metabolic, genotoxic, mutagenic, teratogenic, epigenetic and carcinogenic effects. Arsenic occurs naturally in the Earth's crust, but anthropogenic arsenic emissions have surmounted the emissions from important natural sources such as volcanism. Inorganic arsenicals exhibit acute and chronic toxicities in virtually all cell types and tissues, and hence arsenic intoxication affects multiple systems. Whereas acute arsenic intoxication is rare and relatively easy to diagnose, chronic arsenic intoxication (CAsI) is common but goes often misdiagnosed.Based on a review of the literature as well as our own clinical experience, we propose a chronic arsenic intoxication diagnostic score (CAsIDS). A distinctive feature of CAsIDS is the use of bone arsenic load as an essential criterion for the individual risk assessment of chronic arsenic intoxication, combined with a systemic clinical assessment. We present clinical examples where CAsIDS is applied for the diagnosis of CAsI, review the main topics of the toxicity of arsenic in different cell and organ systems and discuss the therapy and prevention of disease caused or aggravated by chronic arsenic intoxication. CAsIDS can help physicians establish the diagnosis of CAsI and associated conditions.

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“…Transformation of arsenic from its pentavalent to less soluble and toxic trivalent form occurs in the kidneys. Sites prone to damage are capillaries, glomeruli, and tubules [ 28 - 31 ]. Epidemiological analysis and animal studies have revealed that mild and persistent arsenic exposure causes kidney damage and increase the risk of cancer [ 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of Mucuna pruriens against arsenic-induced liver and kidney dysfunction and neurobehavioral alterations in rats

Bairy

Raghavendra

2020

Vet World

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Background and Aim: Intoxication of arsenic in rats is known to result in neurological effects as well as liver and kidney dysfunction. Mucuna pruriens has been identified for its medicinal properties. The aim of the study was to investigate the protective effect of aqueous seed extract of M. pruriens on sodium arsenite-induced memory impairment, liver, and kidney functions in rats. Materials and Methods: The experiment was divided into short-term treatment (45 days) and long-term treatment (90 days), with each group divided into nine sub-groups consisting of six animals each. Sub-groups 1 and 2 served as normal, and N-acetylcysteine (NAC) controls, respectively. Sub-groups 3-9 received sodium arsenite in drinking water (50 mg/L). In addition, sub-group 4 received NAC (210 mg/kg b.wt) orally once daily, sub-groups 5-7 received aqueous seed extract of M. pruriens (350 mg/kg b.wt, 530 mg/kg b.wt, and 700 mg/kg b.wt) orally once daily and sub-groups 8 and 9 received a combination of NAC and aqueous seed extract of M. pruriens (350 mg/kg b.wt and 530 mg/kg b.wt) orally once daily. Following the treatment, the blood was drawn retro-orbitally to assess the liver (serum alanine transaminase [ALT], serum aspartate transaminase, and serum alkaline phosphatase) and kidney (serum urea and serum creatinine) functions. Learning and memory were assessed by passive avoidance test. Animals were sacrificed by an overdose of ketamine, and their Nissl stained hippocampal sections were analyzed for alterations in neural cell numbers in CA1 and CA3 regions. Results: In the short-term treatment, groups administered with M. pruriens 530 mg/kg b.wt alone and combination of NAC + M. pruriens 350 mg/kg b.wt exhibited a significant improvement in memory retention, less severe neurodegeneration, and decrease in serum ALT levels. In long-term treatment, groups administered with M. pruriens 700 mg/kg b.wt alone and combination of NAC+M. pruriens 350 mg/kg b.wt, respectively, showed better memory retention, decreased neural deficits, and reduced levels of kidney and liver enzymes. Conclusion: The seed extract of M. pruriens showed significant enhancement in memory and learning. The number of surviving neurons in the CA1 and CA3 regions also increased on treatment with M. pruriens. Serum ALT, serum urea, and serum creatinine levels showed significant improvement on long-term treatment with M. pruriens.

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Associations between arsenic in drinking water and the progression of chronic kidney disease: A nationwide study in Taiwan

Cited by 69 publications

References 47 publications

Adsorption of Aqueous As (III) in Presence of Coexisting Ions by a Green Fe-Modified W Zeolite

Adsorption of Aqueous As (III) in Presence of Coexisting Ions by a Green Fe-Modified W Zeolite

Chronic arsenic intoxication diagnostic score (CAsIDS)

Protective effect of Mucuna pruriens against arsenic-induced liver and kidney dysfunction and neurobehavioral alterations in rats

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