Associations between Blood Lead Levels and Coronary Artery Stenosis Measured Using Coronary Computed Tomography Angiography

Kim, Suwhan; Kang, WonYang; Cho, Seunghyeon; Lim, Dae-Young; Yoo, Yeongjae; Park, Ryoung Jin; Lee, Byung Chan; Moon, Jai-Dong

doi:10.1289/ehp7351

Cited by 12 publications

(5 citation statements)

References 33 publications

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“…Moderate to severe coronary artery stenosis was significantly associated with BLLs, with an adjusted OR for a 1 µg/dL increase in BLL of 1.14 ( P = 0.017). 22 In our study, it was confirmed that the relationship between the prevalence of CAC, CACS, and BLL was significant before and after adjusting for confounders. This will be sufficient evidence to support the conclusions presented in many studies on the relationship between lead exposure and CVD.…”

Section: Discussionsupporting

confidence: 79%

The Association Between Blood Lead Levels and Coronary Artery Calcium Score Determined by Using Coronary Computed Tomography Angiography

et al. 2023

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Background Lead exposure is a known risk factor for cardiovascular disease (CVD), and coronary artery calcification (CAC) is a biomarker for diagnosing atherosclerotic CVD. This study investigated the association between blood lead level (BLL) and CAC using coronary computed tomography (CT) angiography. Methods This study enrolled 2,189 participants from the general population with no history or symptoms of CVD. All participants underwent coronary CT angiography, health examination, and BLL testing. The association between coronary artery calcium score (CACS) and BLL was analyzed. Results The arithmetic mean of BLL was 2.71 ± 1.26 μg/dL, and the geometric mean was 2.42 (1.64) μg/dL, ranging from 0.12 to 10.14 μg/dL. There was a statistically significant positive correlation between CACS and BLL ( r = 0.073, P < 0.001). Mean BLLs among predefined CACS categories were as follows: absent grade (CACS = 0), 2.67 ± 1.23 μg/dL; minimal grade (> 0, < 10), 2.81 ± 1.25 μg/dL; mild grade (≥ 10, < 100), 2.74 ± 1.29 μg/dL; moderate grade (≥ 100, < 400), 2.88 ± 1.38 μg/dL; severe grade (≥ 400): 3.22 ± 1.68 μg/dL. The odds ratio for severe CAC was 1.242 in association with an 1 μg/dL increase in BLL ( P = 0.042). Conclusion Using coronary CT angiography, we determined a positive correlation between BLL and CAC among participants without CVD from the general population. To reduce the burden of CVD, efforts and policies should be geared toward minimizing environmental lead exposure.

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Section: Discussionsupporting

confidence: 79%

The Association Between Blood Lead Levels and Coronary Artery Calcium Score Determined by Using Coronary Computed Tomography Angiography

et al. 2023

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“…However, they used CT‐angiography to examine the complexity of coronary artery stenosis rather than angiography, which is the golden standard. In addition, they did not exclude the family history of cardiovascular disorders (Kim et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Evaluating the association between opium abuse, blood lead levels, and the complexity of coronary artery disease

Khameneh Bagheri,

Mousavi,

Mehrad‐Majd

et al. 2024

Physiological Reports

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Opium abuse and exposure to heavy metals elevate the risk of coronary artery disease (CAD). Therefore, we aimed to determine the association between opium abuse and blood lead levels (BLLs) and the CAD complexity. We evaluated patients with acute coronary symptoms who underwent coronary angiography, and those with >50% stenosis in at least one of the coronary arteries were included. Furthermore, Synergy between PCI with Taxus and Cardiac Surgery I (SYNTAX I) score and BLLs were measured. Based on the opium abuse, 95 patients were subdivided into opium (45) and control (50) groups. Differences in demographics and CAD risk factors were insignificant between the two groups. The median BLLs were remarkably higher in the opium group than in controls (36 (35.7) and 20.5 μg/dL (11.45), respectively, p = 0.003). We also revealed no significant differences in SYNTAX score between the two groups (15.0 (9.0) and 17.5 (14.0), respectively, p = 0.28). Additionally, we found no significant correlation between BLLs and the SYNTAX scores (p = 0.277 and r = −0.113). Opium abuse was associated with high BLLs. Neither opium abuse nor high BLLs were correlated with the complexity of CAD. Further studies are warranted to establish better the relationship between opium abuse, BLLs, and CAD.

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“…Previous studies mainly focused on the discussion of the risk factors of CAS in the general population and the elderly population. 22,23 This study investigated risk factors for early onset CAS and found that ALDH2 rs671 A/A genotype, overweight, smoking history, and diabetes mellitus were independent risk factors for early onset CAS. SNP rs671 is the main polymorphic site of ALDH2 gene, which is related to the enzyme activity of ALDH2.…”

Section: Discussionmentioning

confidence: 99%

Aldehyde dehydrogenase 2 rs671 a/A Genotype is Associated with an Increased Risk of Early Onset Coronary Artery Stenosis

Rao,

Wang,

Luo

et al. 2024

IJGM

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Background The role of aldehyde dehydrogenase 2 (ALDH2) in cardiovascular diseases has been gradually studied. However, it is unclear whether ALDH2 polymorphism is associated with the risk of early onset (onset age ≤55 years old in men and ≤65 years old in women) coronary artery stenosis (CAS). The association between ALDH2 single nucleotide polymorphism (SNP) rs671 and risk in patients with early onset CAS was investigated in this study. Methods The study included 213 early onset CAS patients and 352 individuals without CAS were set as controls. The ALDH2 rs671 polymorphism was genotyped by polymerase chain reaction (PCR) - microarray. Differences in ALDH2 rs671 genotypes and alleles between patients and controls were compared. Multiple logistic regression analysis was performed after adjusting for gender, body mass index (BMI), smoking history, drinking history, and diabetes mellitus to assess the relationship between ALDH2 rs671 genotypes and early onset CAS risk. Results The frequency of the ALDH2 rs671 G/G genotype was lower in the early onset CAS patients (43.7% vs 55.3%, p =0.007) than that in the controls. The frequency of the ALDH2 rs671 A allele was higher (32.9% vs 25.0%) than that in the controls ( p =0.005). After adjusting for other confounding factors, multivariate logistic regression showed that ALDH2 rs671 A/A genotype (A/A vs G/G: odds ratio (OR) 2.508, 95% confidence interval (CI): 1.130–5.569, p =0.024), overweight (BMI≥24.0 vs 18.5–23.9: OR 5.047, 95% CI: 3.275–7.777, p <0.001), history of smoking (yes vs no: OR 2.813, 95% CI: 1.595–4.961, p <0.001), and diabetes mellitus (yes vs no: OR 2.191, 95% CI: 1.397–3.437, p =0.001) were the independent risk factors of early onset CAS. Conclusion In men ≤55 years old and women ≤65 years old, individuals with ALDH2 rs671 A/A genotype, overweight (BMI ≥24.0 kg/m 2 ), smoking history, and diabetes mellitus increased risk of developing CAS.

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Associations between Blood Lead Levels and Coronary Artery Stenosis Measured Using Coronary Computed Tomography Angiography

Cited by 12 publications

References 33 publications

The Association Between Blood Lead Levels and Coronary Artery Calcium Score Determined by Using Coronary Computed Tomography Angiography

The Association Between Blood Lead Levels and Coronary Artery Calcium Score Determined by Using Coronary Computed Tomography Angiography

Evaluating the association between opium abuse, blood lead levels, and the complexity of coronary artery disease

Aldehyde dehydrogenase 2 rs671 a/A Genotype is Associated with an Increased Risk of Early Onset Coronary Artery Stenosis

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