Associations between body composition and vertebral fracture risk in postmenopausal women

Kuo, Duen-Pang; Chiu, Yen-Lin; Chen, P.-T.; Tsai, Yih-Jian; Hou, Cheng-Han; Chen, Y.-L.; Chu, Cordia Ming-Yeuk

doi:10.1007/s00198-021-06178-w

Cited by 4 publications

(5 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It seems that fat mass is a better determinant of BMD of the lumbar spine, and LBM has a greater effect on hip BMD [9]. The described relationships between BMD and fat mass and LBM in the case of FR are not consistently reported, especially in cross-sectional studies [10,11]. Dolan et al included in their meta-analysis 16 clinical trials [12].…”

Section: Bmd Ct and Fracturementioning

confidence: 99%

Fracture risk in obesity: a narrative review

et al. 2022

View full text Add to dashboard Cite

sitometry (DXA) or computed tomography (CT), which provide information on the composition of the whole body, are much more accurate.Opinions on the beneficial effects of obesity on the skeletal system are divergent because there are a number of arguments for and against this hypothesis. It is important to stress that opinions were the result of different methods to assess obesity and different populations. Therefore, the aim of this narrative review is to focus on the estimation of fracture risk in patients with obesity caused by hyperalimentation, adults, seniors, and after bariatric surgery and the indication of specific treatment features in these populations. Fracture risk in alimentary obesityThe FR appears to be influenced not only by the weight itself from excess body weight (anthropometric parameters), but also by the relative or absolute weight or amount/volume of adipose tissue associated with it or with its distribution (body composition). In this context, more information on the FR in obesity may be provided by bone mineral density (BMD), CT, the mass of adipose and lean tissue, as well as their mutual proportions. This seems to be significant, especially in premenopausal

show abstract

Section: Bmd Ct and Fracturementioning

confidence: 99%

Fracture risk in obesity: a narrative review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Therefore, BMI might not be an appropriate parameter to evaluate the relationship between obesity and VF risk, and further studies are needed to investigate the influence of other measurements of obesity on VF risk. Some studies have revealed that body composition helps to determine the difference in bone status between VF and non-VF participants (30,31). Kuo et al (31) found the prevalence of VFs is higher in postmenopausal women with increased BMI and fat percentage and in those with loss of lean mass.…”

Section: Discussionmentioning

confidence: 99%

“…Kuo et al. ( 31 ) found the prevalence of VFs is higher in postmenopausal women with increased BMI and fat percentage and in those with loss of lean mass. It’s reported that the risk of having osteoporosis was double in individuals with sarcopenia than in normal individuals ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

Bone Microarchitecture in Obese Postmenopausal Chinese Women: The Chinese Vertebral Osteoporosis Study (ChiVOS)

Jiang

Liu

et al. 2022

Front. Endocrinol.

View full text Add to dashboard Cite

BackgroundObesity is associated with improved bone mass and microarchitecture in Caucasian individuals, but evidence in obese Asian individuals is lacking.ObjectiveTo analyze the areal bone mineral density (aBMD) and bone microarchitecture in normal-weight, overweight, and obese postmenopausal Chinese women.MethodsA total of 243 postmenopausal women from the Chinese Vertebral Osteoporosis Study (ChiVOS) were included and were divided into three groups (OB, obese group; OW, overweight group; NW, normal weight group) by BMI level. aBMD, trabecular bone score (TBS), and appendicular lean mass (ALM) were measured by dual‐energy X‐ray absorptiometry (DXA). Bone microarchitecture was measured by HR-pQCT at the distal radius and tibia. X-ray was performed to confirm vertebral fractures (VFs). Multiple linear regression was used to evaluate the correlations between bone parameters and ALM after adjusting for confounding variables.ResultsThe prevalence of VFs and clinical fractures were similar among the groups. Participants in the OB group showed a lower level of osteocalcin with comparable levels of other bone turnover markers (BTMs). The aBMD at several skeletal sites was higher in the OB group than in the NW group after adjusting for age (p<0.01 for all comparisons). At the radius, the OB group had a higher Ct.Ar, Tb.vBMD, Tb.BV/TV, Tb.N, Tb.Th, and Ct.Th than the NW group after adjusting for covariates (p<0.05 for all). Differences of a similar magnitude were found at the distal tibia. There was a trend of decreasing trend in Tb.Sp, Tb.1/N/SD, and Ct.Po among groups at both sites. However, the bone microarchitecture did not differ between participants with severe obesity (BMI≥35.0kg/m2) and those with 30.0≤BMI<35 kg/m2. Multiple linear regression revealed that the associations between ALM and most of the bone microarchitecture parameters at both sites were much stronger than the association between body weight and bone parameters.ConclusionWe have observed significant improvements in aBMD, bone geometry, and bone microarchitecture in obese postmenopausal Chinese women. Except for a lower level of osteocalcin in the OB group, no significant differences in BTMs were found among the groups. Compared with body weight, ALM may explain greater variance in the improvement of bone microarchitecture parameters.

show abstract

“…A reduction in lean mass has been previously reported as a risk factor for osteoporosis both in postmenopausal ( 105 ) and in women with premature ovarian failure ( 106 ). The association between reduced lean mass and a reduction in BMD has been demonstrated also in elderly males ( 107 ).…”

Section: Role Of Skeletal Muscle and Body Compositionmentioning

confidence: 99%

Osteoporosis and bone metabolism in patients with Klinefelter syndrome

Grande

Graziani

Mambro

et al. 2023

Endocrine Connections

View full text Add to dashboard Cite

Low bone mass is common in men with Klinefelter syndrome (KS), with a prevalence of 6-15% of osteoporosis and of 25-48% of osteopenia. Reduced bone mass has been described since adolescence and it might be related to both reduced bone formation and higher bone resorption. Although reduced testosterone levels are clearly involved in the pathogenesis, this relation is not always evident. Importantly, fracture risk is increased independently from bone mineral density (BMD) and testosterone levels. Here we discuss the pathogenesis of osteoporosis in patients with KS, with a particular focus on the role of testosterone and testis function. In fact, other hormonal mechanisms, such as global Leydig cell dysfunction, causing reduced Insulin-like factor 3 (INSL3) and 25-OH vitamin D levels, and high FSH and estradiol levels, might be involved. Furthermore, genetic aspects related to the supernumerary X chromosome might be involved, as well as androgen receptor expression and function. Notably, body composition, skeletal mass and strength, and age at diagnosis are other important aspects. Although Dual-Energy X-ray Absorptiometry (DXA) is recommended in the clinical workflow for patients with KS to measure BMD, recent evidence suggests that alterations in the microarchitecture of the bones and vertebral fractures might be present even in subjects with normal BMD. Therefore, analysis of trabecular bone score (TBS), high resolution peripheral quantitative CT and vertebral morphometry seem promising tools to better estimate the fracture risk of patents with KS. This review also summarizes the evidence on the best available treatments for osteoporosis in men with KS, with or without hypogonadism.

show abstract

Associations between body composition and vertebral fracture risk in postmenopausal women

Cited by 4 publications

References 22 publications

Fracture risk in obesity: a narrative review

Fracture risk in obesity: a narrative review

Bone Microarchitecture in Obese Postmenopausal Chinese Women: The Chinese Vertebral Osteoporosis Study (ChiVOS)

Osteoporosis and bone metabolism in patients with Klinefelter syndrome

Contact Info

Product

Resources

About