Associations between body composition and the risk of fracture according to bone mineral density in postmenopausal women: a population-based database cohort study

Lee, Jeongmin; Jung, Jin-Hyung; Kim, Jinyoung; Jeong, Chaiho; Ha, Jeonghoon; Kim, Min-Hee; Lee, Jung-Min; Chang, Sang-Ah; Baek, Ki-Hyun; Han, Kyungdo; Lim, Dong-Jun

doi:10.1093/ejendo/lvad156

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…Osteoporosis is a systemic disease characterized by bone metabolism disorders, unstable bone resorption and formation [33]. Its characteristic is a decrease in bone quality, a decrease in bone trabeculae, and the occurrence of brittle fractures [17]. The incidence rate is higher in the elderly, especially in postmenopausal women [29].…”

Section: Introductionmentioning

confidence: 99%

miR-595/Cldnd1 axis: a potential risk factor for bone loss in postmenopausal women with hip osteoporotic fracture

Jingyue,

Peixin,

Xiao

2024

Preprint

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Background Recently researches have reported that miRNA and its target genes are associated with osteoporosis. MiRNAs/mRNA axis might be an potential diagnostic marker for osteoporosis. Purposes The aim of this study is to explore the potential miRNA and mRNA markers by bioinformatics method and clinical analysis. Patients and Methods The miRNA expression profiles were obtained from GSE74209, GSE64433 and GSE115773 in Gene expression Omnibus (GEO). The mRNA expression profiles were obtained from GSE100609. Wayne intersection were used to explore the different expressed miRNAs (DE-miRs). Select the miRNA with the highest Fold Change for subsequent research. Screening of miRNA target genes using TargetScan and miRDB tools. GO and KEGG analyses of target genes (TGs) function were performed. Validate the selected TGs in the GSE100609. We collected female patients with femural intertrochanteric fractures from July 1, 2023 to October 31, 2023. Patient's bone marrow and clinical data were collected. MiRNA and the target mRNA differentially expressed in bone marrow were verified through RT-qPCR. All data were subjected to Shapiro-Wilk test. Using Pearson or Spearman test to detect the correlation between various indicators, and then incorporating indicators related to bone density into multiple linear regression equations. Partial correlation analysis was used to analyze the correlation between the final indicators and bone density. Results A total of 140 DE-miRs were identified between high bone density and low bone density women. Set the fold change to “>1” and ultimately include 5 miRNAs. Using miR-595 (highest |log2 FC|) as the subject of subsequent research. 3542 targeted mRNAs were predicted from TargetScan and 362 were from miRDB. 337 TGs were intersected, which were mainly enriched in nucleus. Only Cldnd1 were identified using the GSE100609 dataset. We found that miR-595 was highly expressed in patients with high bone mass, while its target gene Cldnd1 was downregulated. There was a strong collinearity between miR-595 and Cldnd1. Further multiple linear regression analysis showed a high correlation between miR-595 and bone density. Conclusions These data suggest that Cldnd1 might be a downstream factor of miR-595. miR-595/Cldnd1 axis might be an independent risk factor for decreased bone mass.

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Section: Introductionmentioning

confidence: 99%

miR-595/Cldnd1 axis: a potential risk factor for bone loss in postmenopausal women with hip osteoporotic fracture

Jingyue,

Peixin,

Xiao

2024

Preprint

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A natural agent, 5-deoxycajanin, mitigates estrogen-deficiency bone loss via modulating osteoclast-osteoblast homeostasis

Chen,

Jiang,

et al. 2024

International Immunopharmacology

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Inverse U-shaped association between weight-adjusted waist index and femur bone mineral density in the older adults:NHANES 2005-2018

Wang,

Lv,

Huang

et al. 2024

Preprint

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The weight-adjusted waist Index (WWI) emerges as a novel metric for assessing obesity. The aim of this research was to explore the association between WWI and total femoral Bone Mineral Density (BMD) in the older adults of the United States. This study involving individuals aged 60 years and older utilized data from the National Health and Nutrition Examination Survey (NHANES) across five survey cycles (from 2005–2010, 2013–2014, and 2017–2018) to examine the association between WWI and total femur BMD. In this research, we employed a suite of statistical methods to explore both linear and nonlinear associations. Additionally, a threshold effect analysis was conducted to ascertain the saturation threshold for WWI. Analysis via multivariate linear regression uncovered a notably positive correlation between WWI and total femur BMD among 7292 US seniors aged 60 years and older [β: 0.0138, 95% CI: (0.0069, 0.0206), P: 0.0003]. Consistent positive correlations were observed across various demographic subgroups. Furthermore, in the smooth curve fitting analysis ,an inverse U-shaped association was identified between the WWI and total femur BMD.And in the threshold effect analysis, the critical inflection point was established at 11.93 cm/√kg. So, this research established an inverse U-shaped association between WWI and total femur BMD in the older adults,and maintaining a certain level of WWI may have a positive protective effect on total femur BMD of the older adults in the United States.

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Associations between body composition and the risk of fracture according to bone mineral density in postmenopausal women: a population-based database cohort study

Cited by 3 publications

References 32 publications

miR-595/Cldnd1 axis: a potential risk factor for bone loss in postmenopausal women with hip osteoporotic fracture

miR-595/Cldnd1 axis: a potential risk factor for bone loss in postmenopausal women with hip osteoporotic fracture

A natural agent, 5-deoxycajanin, mitigates estrogen-deficiency bone loss via modulating osteoclast-osteoblast homeostasis

Inverse U-shaped association between weight-adjusted waist index and femur bone mineral density in the older adults:NHANES 2005-2018

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