Associations between brain‐derived neurotrophic factor and cognitive impairment in panic disorder

Wang, Wen-Chen; Liu, Yuanyuan; Luo, Shuqing; Guo, Xiaoyun; Luο, Xingguang; Zhang, Yong

doi:10.1002/brb3.1885

Cited by 8 publications

(6 citation statements)

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“…From our initial database search, 646 records were identified (311 from PubMed, EMBASE, Ovid, and Wiley Online Library and 320 from CNKI, WANFANG DATA, and VIP; 15 more studies were retrieved from related citations). After excluding articles according to the inclusion and exclusion criteria, 25 reports [18][19][20][21][22][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] were included in the qualitative description and the analysis of the distributions of alleles of BDNF Val66Met in patients with stroke. Five repo rts 19,20,22,38,45 including 2089 participants were applied in the meta-analysis to assess the differences in recovery outcomes in patients with stroke having different genotypes (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

The Influence of Val66Met Polymorphism in Brain-Derived Neurotrophic Factor on Stroke Recovery Outcome: A Systematic Review and Meta-analysis

Fang

Zhi

et al. 2021

Neurorehabil Neural Repair

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Background and purpose. A single nucleotide polymorphism at nucleotide 196 (G/A) in the human brain-derived neurotrophic factor ( BDNF) gene produces an amino acid substitution (valine to methionine) at codon 66(Val66Met). It is unclear whether carriers of this substitution may have worse functional outcomes after stroke. We aimed to explore the distribution of Val66Met polymorphism and evaluate the effect of different genotypes on stroke functional recovery. Methods. Several databases were searched using the keywords BDNF or brain-derived neurotrophic factor, codon66, G196A, rs6265, or Val66Met, and stroke. Results. A total of 25 articles were relevant to estimate the distribution of alleles; 5 reports were applied in the meta-analysis to assess genetic differences on recovery outcomes. The genetic model analysis showed that the recessive model should be used; we combined data for AA versus GA+GG (GG—Val/Val, GA—Val/Met, AA—Met/Met). The results showed that stroke patients with AA might have worse recovery outcomes than those with GA+GG (odds ratio = 1.90; 95% CI: 1.17-3.10; P = .010; I2 = 69.2%). Overall, the A allele may be more common in Asian patients (48.6%; 95% CI: 45.8%-51.4%, I2 = 54.2%) than Caucasian patients (29.8%; 95% CI: 7.5%-52.1%; I2 = 99.1%). However, in Caucasian patients, the frequency of the A allele in Iranians (87.9%; 95% CI: 83.4%-92.3%) was quite higher than that in other Caucasians (18.7%; 95% CI: 16.6%-20.9%; I2 = 0.00%). Conclusion. Val66Met AA carriers may have worse rehabilitation outcomes than GA+GG carriers. Further studies are needed to determine the effect of Val66Met polymorphism on stroke recovery and to evaluate this relationship with ethnicity, sex, age, stroke type, observe duration, stroke severity, injury location, and therapies.

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Section: Resultsmentioning

confidence: 99%

The Influence of Val66Met Polymorphism in Brain-Derived Neurotrophic Factor on Stroke Recovery Outcome: A Systematic Review and Meta-analysis

Fang

Zhi

et al. 2021

Neurorehabil Neural Repair

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“…Among these, 39 articles were further screened to eliminate duplicated searches. Finally, there were only 11 articles that met the inclusion criteria with available data (Lam et al ., 2004; Shimizu et al ., 2005; Lim et al ., 2007; Ishii et al ., 2009; Otowa et al ., 2009; Konishi et al ., 2014; Han et al ., 2015; Zou et al ., 2019; Wang et al ., 2020; Yang et al ., 2021; Chu et al ., 2022), involving 2203 cases and 2554 controls. The flow chart of literature selection is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Pathoclinical associations between panic disorders and the brain-derived neurotrophic factor Val66Met polymorphism: an updated meta-analysis

Lei¹,

Song

Wu³

et al. 2023

Psychiatric Genetics

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Prior studies have indicated the pathological role of brainderived neurotrophic factor (BDNF) gene polymorphism in panic disorders (PD). A functionally less active BDNF Val66Met mutant was previously detected in PD patients with different ethnic backgrounds. However, the results remain inconclusive or inconsistent. A meta-analysis was used to explore the consistency of the BDNF Val66Met mutant's association with PD irrespective of the subject's ethnicity. Relevant case-controlled full-length clinical and preclinical reports were retrieved by database searching, and 11 articles involving 2203 cases and 2554 controls were systematically selected per the standard inclusion criteria. Eleven articles were finally included that explored the relationship between the Val66Met polymorphism and PD risk susceptibility. Statistical analysis revealed a significant genetic association of the mutation, allele frequencies, and genotype distributions of BDNF with PD onset. Our findings demonstrated that the BDNF Val66Met is a susceptibility factor of PD.

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“…Of these, 31 articles were selected for full‐text assessment. Finally, 12 articles met the inclusion criteria and were included (An et al., 2019 ; Carlino et al., 2015 ; Chen et al., 2022 , 2017 ; Chu et al., 2022 ; Kim et al., 2019 ; Kobayashi et al., 2005 ; Li et al., 2023 ; Maron et al., 2009 ; Molendijk et al., 2012 ; Ströhle et al., 2010 ; Wang et al., 2020 ) (see Figure 1 for the PRISMA flow diagram).…”

Section: Resultsmentioning

confidence: 99%

“…The qualitative synthesis revealed heterogeneity in terms of study design, BDNF measurement methods, and panic disorder severity measures. Recent studies reported lower BDNF protein levels in individuals with panic disorder compared to healthy controls (Chu et al, 2022;Li et al, 2023;Wang et al, 2020). However, there were some discrepancies among the findings, with some studies reporting no significant differences (An et al, 2019;Carlino et al, 2015;Chen et al, 2017Chen et al, , 2022Kim et al, 2019;Kobayashi et al, 2005;Molendijk et al, 2012) or even higher BDNF levels in individuals with panic disorder (Maron et al, 2009).…”

Section: Qualitative Synthesismentioning

confidence: 99%

Brain‐derived neurotrophic factor (BDNF) levels in panic disorder: A systematic review and meta‐analysis

Shafiee,

Jafarabady,

Mohammadi

et al. 2023

Brain and Behavior

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BackgroundThe existing literature on the association between brain‐derived neurotrophic factor (BDNF) protein levels and panic disorder presents inconsistent findings. This systematic review and meta‐analysis aim to synthesize the available evidence and determine the overall effect of BDNF protein levels in individuals diagnosed with panic disorder.MethodsA comprehensive literature search was conducted using electronic databases (PubMed, Embase, Scopus, PsycINFO, and Web of Science) from inception to April 21, 2023. The search strategy included relevant keywords and medical subject headings terms related to BDNF, panic disorder, and protein levels. A random‐effects model was used for the meta‐analysis, and subgroup analyses were performed to explore heterogeneity. Publication bias was assessed using funnel plots and statistical tests.ResultsA total of 12 studies met the inclusion criteria. The meta‐analysis demonstrated a significant decrease in BDNF protein levels in individuals with panic disorder (SMD = −.53, 95% CI: −1.02 to −.04, p < .001; I2: 92%). The results of subgroup and meta‐regression analyses were not statistically significant. No significant publication bias was observed based on the results of Egger's regression test (p‐value = .3550).ConclusionThis systematic review and meta‐analysis provide evidence of lower BDNF protein levels in individuals diagnosed with panic disorder compared to healthy controls. The findings suggest a potential role for BDNF dysregulation in the pathophysiology of panic disorder. Further research is warranted to elucidate the underlying mechanisms and potential therapeutic implications.

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Associations between brain‐derived neurotrophic factor and cognitive impairment in panic disorder

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 8 publications

References 50 publications

The Influence of Val66Met Polymorphism in Brain-Derived Neurotrophic Factor on Stroke Recovery Outcome: A Systematic Review and Meta-analysis

The Influence of Val66Met Polymorphism in Brain-Derived Neurotrophic Factor on Stroke Recovery Outcome: A Systematic Review and Meta-analysis

Pathoclinical associations between panic disorders and the brain-derived neurotrophic factor Val66Met polymorphism: an updated meta-analysis

Brain‐derived neurotrophic factor (BDNF) levels in panic disorder: A systematic review and meta‐analysis

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