2022
DOI: 10.1097/qai.0000000000002841
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Associations Between Central Obesity and Lifelong Antiviral Therapy in Adults Living With HIV Acquired From Early Childhood

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Cited by 5 publications
(3 citation statements)
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“…Increases in the waist to hip ratio were positively correlated with increases in triglycerides (r = 0.35, p = 0.03). While the prevalence of individuals who were either overweight (body mass index (BMI) > 25–29) or obese (BMI > 30) was similar to that of 47 HIV-negative controls (47% vs. 51% and 20% vs. 17%, respectively), those LWPaHIV had higher rates of metabolic syndrome (13% vs. 4%), which was defined as three of five abnormal measurements; elevated waist circumference, triglycerides, blood pressure, fasting glucose and/or elevated triglycerides or reduced HDL cholesterol [ 72 ]. Similarly, in a French study of 18–30 year olds LWPaHIV, 13.2% of men and 10.4% of women were identified with metabolic syndrome, compared to 10.6% and 1.7% in an HIV-negative control population, with increased central adiposity and abnormalities in lipid profiles demonstrated in those LWPaHIV [ 73 ].…”
Section: Metabolic and Cardiovascular Healthmentioning
confidence: 98%
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“…Increases in the waist to hip ratio were positively correlated with increases in triglycerides (r = 0.35, p = 0.03). While the prevalence of individuals who were either overweight (body mass index (BMI) > 25–29) or obese (BMI > 30) was similar to that of 47 HIV-negative controls (47% vs. 51% and 20% vs. 17%, respectively), those LWPaHIV had higher rates of metabolic syndrome (13% vs. 4%), which was defined as three of five abnormal measurements; elevated waist circumference, triglycerides, blood pressure, fasting glucose and/or elevated triglycerides or reduced HDL cholesterol [ 72 ]. Similarly, in a French study of 18–30 year olds LWPaHIV, 13.2% of men and 10.4% of women were identified with metabolic syndrome, compared to 10.6% and 1.7% in an HIV-negative control population, with increased central adiposity and abnormalities in lipid profiles demonstrated in those LWPaHIV [ 73 ].…”
Section: Metabolic and Cardiovascular Healthmentioning
confidence: 98%
“…Evidence suggests a high prevalence of obesity in people living with HIV [ 70 ], which may be related to ART-use and demographic characteristics as well as secondary to lifestyle factors [ 71 ]. Alterations in body fat composition have also been demonstrated in adults LWPaHIV, with a recent US study reporting higher rates of truncal fat deposition in those LWPaHIV ( n = 70, median age of 26 and IQR—23–29), measured by waist to hip ratio and trunk to limb fat ratio, when compared to people without HIV (0.91 ± 0.1 vs. 0.84 ± 0.1 and 0.98 ± 0.3 vs. 0.76 ± 0.2, both p < 0.0001, respectively), who are associated with a chronic exposure to ART, particularly historic regimens that included the non-nucleoside reverse transcriptase inhibitors (NRTIs) stavudine (r = 0.36, p = 0.02) and didanosine (r = 0.39, 0.01) [ 72 ]. Increases in the waist to hip ratio were positively correlated with increases in triglycerides (r = 0.35, p = 0.03).…”
Section: Metabolic and Cardiovascular Healthmentioning
confidence: 99%
“…AIDS-related inflammation and immune activation also occur throughout the infection and treatment process, which is related to the persistence of HIV, translocation of intestinal flora, reduction of regulatory T cells, and combination or secondary infection with other viruses [80] , [81] . People who were born with HIV or acquired HIV in early childhood were found to be significantly more likely to develop metabolic abnormalities, including insulin resistance, high triglyceride levels, and adverse weight gain [82] .…”
Section: Roles Of Il-6-mediated Immunometabolic Reprogramming In Vira...mentioning
confidence: 99%