Associations between cerebrospinal fluid biomarkers in individuals with normal cognitive function, mild cognitive impairment, or Alzheimer's disease by amyloid PET status: a cross-sectional survey

Abstract

Background It is unclear whether cerebrospinal fluid (CSF) biomarkers play different roles in mild cognitive impairment (MCI) and Alzheimer's disease. We aimed to investigate whether there is a difference in the correlations between CSF tau, P-tau, and Aβ42 in individuals with normal cognitive function, early MCI, late MCI, or Alzheimer's disease. Additionally, we aimed to identify risk factors for the different diagnoses. Methods In this cross-sectional study, we included individuals aged 55-90 years from the Alzheimer's Disease Neuroimaging Initiative (ADNI) with normal cognitive function, early MCI, late MCI, or Alzheimer's disease. From the ADNI, we obtained florbetapir (18 F) PET data and concentrations of CSF tau, P-tau, and Aβ42. Partial correlation analysis was performed to assess the correlations between the concentrations of CSF tau, P-tau, and Aβ42 after controlling for age. Multinomial logistic regression was conducted to assess the correlations between demographic and clinical variables in each group.