Associations between childhood body size and seventeen adverse outcomes: analysis of 65,057 European women

Li, Jingmei; Eriksson, Mikael; He, Weiling; Hall, Per; Czene, Kamila

doi:10.1038/s41598-017-17258-5

Cited by 8 publications

(7 citation statements)

References 58 publications

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“…Our study is based on measured anthropometric values and registered diagnoses; this contrasts with most other studies in this field which have relied on self-reported childhood size and only few cases of self-reported PCOS or PCOS-related symptoms. None- theless, consistent with our study, 5 other studies found that a high BMI or a large body size in girls was associated with an increased risk of self-reported hirsutism, menstrual problems, or PCOS, compared with girls with a normal weight or a smaller body size [10][11][12][13]15]. Furthermore, we showed that girls without overweight during childhood, or with overweight in early or late childhood only, had a lower risk of PCOS than those with overweight at both ages.…”

Section: Discussionsupporting

confidence: 92%

“…Birthweight, as an indicator of the intrauterine environment, may be inversely associated with PCOS risk but there is uncertainty about this, as the association is not significant in largescale studies, suggesting a publication bias [9]. Six studies have investigated links between body size in childhood and a subsequent risk of developing PCOS, and generally found positive associations [10][11][12][13][14][15]. However, these studies were limited by using self-reported diagnoses of PCOS or its symptoms only, and most studies assessed childhood body size by self-report.…”

Section: Introductionmentioning

confidence: 99%

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Birthweight, Childhood Body Mass Index, Height and Growth, and Risk of Polycystic Ovary Syndrome

Aarestrup¹,

Pedersen²,

Thomas³

et al. 2021

Obes Facts

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Introduction: Adult obesity is linked with polycystic ovary syndrome (PCOS), but the importance of body size at ages before PCOS is diagnosed is unknown. Objective: To investigate associations between a woman’s own birthweight, childhood body mass index (BMI), height and growth patterns in relation to her risk of PCOS. Methods: We included 65,665 girls from the Copenhagen School Health Records Register, born in the period 1960–1996, with information on birthweight and measured weight and height at the ages of 7–13 years. Overweight was defined using International Obesity Task Force (IOTF) criteria. From the Danish National Patient Register, 606 women aged 15–50 years were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated by Cox regression analysis. Results: Birthweight was not associated with PCOS. At the age of 7–13 years, girls with overweight had a higher risk of developing PCOS than girls without overweight; HR 2.83 (95% CI 2.34–3.42) at age 7 years and 2.99 (95% CI 2.38–3.76) at age 13 years. Furthermore, girls with overweight at both 7 and 13 years had a higher risk of developing PCOS than girls without overweight or overweight at only one age. Height was positively associated with PCOS risk at all ages. Girls who were persistently tall or changed from tall to average height had a higher risk of developing PCOS than girls with average height growth. Conclusion: Overweight and tall stature in childhood are positively associated with PCOS risk, but birthweight is not.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Birthweight, Childhood Body Mass Index, Height and Growth, and Risk of Polycystic Ovary Syndrome

Aarestrup¹,

Pedersen²,

Thomas³

et al. 2021

Obes Facts

View full text Add to dashboard Cite

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“…Low weight and dieting have also predicted subthreshold anorexia nervosa in an adult female population (Stice, Gau, Rohde, & Shaw, 2017). However, other studies report that elevated premorbid BMI (Berkowitz et al, 2016) and larger childhood body size (Li, Eriksson, He, Hall, & Czene, 2017) increased risk for anorexia nervosa. To further our understanding of the role that premorbid BMI plays in the emergence of eating disorders, we explored the developmental association between childhood BMI and later eating disorder traits in adolescence (as measured by the Eating Disorder Inventory-2, [EDI; Garner, 1991]) in a longitudinal twin sample.…”

Section: Introductionmentioning

confidence: 99%

Childhood body mass index and development of eating disorder traits across adolescence

Wiklund

Kuja‐Halkola

Thornton

et al. 2018

Euro Eating Disorders Rev

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“…Little is known about the potential association between childhood and adolescent BMI and cervical cancer risk later in life. Childhood body size (based on recall data) was not associated with risk for adult cervical cancer (based on linkage with the national cancer registry) in a study of 65 057 Swedish women 32. We report, based on measured BMI, lower risk for adult pre-malignant cervical disease in overweight and obese adolescents, but not for invasive cervical cancer.…”

Section: Discussionmentioning

confidence: 70%

Adolescent characteristics and incidence of pre-malignant disease and invasive tumors of the cervix

Boker¹,

Twig

Klaitman-Meir

et al. 2020

International Journal of Gynecological Cancer

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IntroductionPre-malignant cervical disease and invasive cervical cancer present a significant global health burden with respect to morbidity and mortality, mostly in low- and middle-income countries. Human papillomavirus (HPV) infection typically manifests for the first time in adolescence. We aimed to identify adolescent sociodemographic and anthropometric characteristics associated with subsequent risk for pre-malignant cervical disease and cervical cancer, in a country that offers free screening and HPV vaccines.MethodsThis historical cohort study included 969 123 Israeli women examined and anthropometrically measured at age 17 years between January 1967 and December 2011. Data on pre-malignant disease and invasive cervical tumors were obtained from the national cancer registry by linkage. We excluded non-Jewish minorities (a total of 25 472 women) and orthodox/ultraorthodox Jewish women since these populations are not required by law to serve in the military, as well as women with a pre-examination diagnosis of cancer. Cox proportional hazards regression models were applied per each lesion type, adjusted for origin, measured body mass index, height, education, dwelling type, birth year, and age at examination.ResultsIn total, 5094 and 859 incident pre-malignant cervical disease and cervical cancer cases, respectively, were diagnosed during a median follow-up of 17.6 years. Risk for both lesions was origin-dependent, with higher incidence in women of North-African origin (HR (pre-malignant cervical disease) 1.22, 95% CI 1.04 to 1.42; HR (cervical cancer) 1.87, 95% CI 1.30 to 2.69) compared with European origin. Height, lower education, and later birth year were associated with higher pre-malignant cervical disease and cervical cancer risk also. Adolescent overweight (HR 0.81, 95% CI 0.74 to 0.90) and obesity (HR 0.56, 95% CI 0.43 to 0.71) status were associated with reduced pre-malignant cervical disease but not cervical cancer incidence, as did urban (vs rural) residence.DiscussionEthnic background, tall stature, and education were associated with pre-malignant cervical disease and cervical cancer incidence, while adolescent overweight and obesity were inversely associated with only pre-malignant cervical disease. Despite free screening and HPV vaccines, these findings suggest that there is still a need for appropriate safe sex and screening education in adolescence.

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Associations between childhood body size and seventeen adverse outcomes: analysis of 65,057 European women

Cited by 8 publications

References 58 publications

Birthweight, Childhood Body Mass Index, Height and Growth, and Risk of Polycystic Ovary Syndrome

Birthweight, Childhood Body Mass Index, Height and Growth, and Risk of Polycystic Ovary Syndrome

Childhood body mass index and development of eating disorder traits across adolescence

Adolescent characteristics and incidence of pre-malignant disease and invasive tumors of the cervix

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