Associations between chronotype, road accidents and polymorphisms in genes linked with biological clock and dopaminergic system

Taranov, Anton O.; Puchkova, Alexandra N.; Slominsky, Petr; Tupitsyna, T. V.; Dementiyenko, V. V.; Дорохов, В. Б.

doi:10.17116/jnevro20171174228-33

Cited by 3 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Being a T-allele carrier did contribute significantly to the risk of repeatedly committing DWI, showing indeed increased impulsivity and more serious alcohol-related problems among T-allele carriers. Recently in a study of bus drivers, NPSR1 A/A homozygotes had higher incidence of self-reported traffic accidents (44,54). In our study, we did not find any association between NPSR1 and traffic accidents.…”

Section: Discussionmentioning

confidence: 97%

“…NPS has up to 10 times higher potency at the receptor encoded by the T-allele (107Ile) compared to the A-allele-encoded receptor, leading to more effective signal transduction with mobilization of intracellular Ca 2+ , stimulation of cyclic adenosine monophosphate synthesis and induction of mitogen-activated protein kinases phosphorylation (43). Recently Taranov and colleagues (44) found in a study with bus drivers that NPSR1 was associated with increased risk of a road accident. The T-allele of the NPSR1 rs324981 polymorphism has been associated with increased impulsivity and ADHD-related traits (39,42).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relapse of drunk driving and association with traffic accidents, alcohol-related problems and biomarkers of impulsivity

Tokko

Eensoo

Vaht

et al. 2018

Acta Neuropsychiatr.

View full text Add to dashboard Cite

ObjectiveIndividual biological predispositions should play a role in risky driving behaviour. Platelet monoamine oxidase (MAO) activity, dopamine transporter gene (DAT1) and neuropeptide S receptor 1 (NPSR1) gene polymorphisms have been identified as markers of impulsivity, alcohol use and excessive risk-taking. We aimed to find out how this knowledge on neurobiology of impulsivity applies to drunk driving and traffic behaviour in general.MethodsWe have longitudinally examined the behaviour of drunk drivers (n = 203) and controls (n = 211) in traffic, in association with their alcohol-related problems, personality measures and the three biomarkers. We analysed differences between the subjects based on whether they had committed driving while impaired by alcohol (DWI) violation in a 10-year time period after recruitment or not and investigated further, what kind of predictive value do the different biomarkers have in committing DWI and other traffic violations and accidents.ResultsThe original drunk drivers group had lower platelet MAO activity but further DWI was not significantly associated with this measure. Being a NPSR1 T-allele carrier contributed to the risk of repeatedly committing DWI. DAT1 9R carriers in contrast were involved in more traffic accidents by their own fault (active accidents), compared to 10R homozygotes in the whole sample. All groups with DWI also had significantly more alcohol-related problems and higher scores in maladaptive impulsivity compared to controls without DWI.ConclusionsEstablished biological markers of alcohol use and impulsivity can be reliably associated with everyday traffic behaviour and help in contributing to the understanding of the need for more personalized prevention activities.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Relapse of drunk driving and association with traffic accidents, alcohol-related problems and biomarkers of impulsivity

Tokko

Eensoo

Vaht

et al. 2018

Acta Neuropsychiatr.

View full text Add to dashboard Cite

show abstract

Effects of Photoperiod on Acetaminophen-Induced Hepatotoxicity in Mice

et al. 2019

View full text Add to dashboard Cite

How have our clocks evolved? Adaptive and demographic history of the out-of-African dispersal told by polymorphic loci in circadian genes

Putilov

Дорохов

Полуэктов

2017

Chronobiology International

View full text Add to dashboard Cite

The mechanism of the molecular circadian clocks is currently understood as a transcription/translation feedback loop involving more than ten genes. Genetic variation at some of loci in these genes has been shaped by adaptation to environmental factors. In particular, latitudinal clines in allele frequency were documented in several animal species, but the contradictory conclusions were drawn from the results of rare human studies. Here we tested whether the out-of-African dispersal of human populations to higher latitudes of the Eurasian continent was associated with latitude-dependent shifts in allele frequency at polymorphic loci in genes of three (reference, circadian and skin pigmentation) groups. In order to detect the genetics-based signatures left by latitude-driven adaptation and to distinguish them from the confounding effects of population demographic history, we analyzed allele frequencies in 1594 individuals from 5 African and 11 Eurasian populations of the 1000 Genomes Project Phase 3. Up to 80 polymorphisms with global minor allele frequency > 0.2 were sampled from each of 36 genes (1665 polymorphisms in total). As expected, percentage of polymorphisms demonstrating both significantly enlarged differentiation of Eurasian populations on allele frequency and significant correlation between latitude and allele frequency was significantly higher in pigmentation genes compared to circadian genes and in circadian genes compared to reference genes. We also showed that the latitude-driven adaptation can be separated from genetic consequences of demographic perturbations by comparison of results obtained for the whole set of 16 African and Eurasian populations with results for only Eurasian populations that share the common demographic history. The revealed latitudinal clines in allele frequency seemed to be shaped by polygenic selection occurring by small allele frequency shifts spread across many loci in circadian and non-circadian genes. The present results provided a rationale for necessity to facilitate candidate gene studies by prioritizing genetic markers of chronotype.

show abstract

Associations between chronotype, road accidents and polymorphisms in genes linked with biological clock and dopaminergic system

Cited by 3 publications

References 19 publications

Relapse of drunk driving and association with traffic accidents, alcohol-related problems and biomarkers of impulsivity

Relapse of drunk driving and association with traffic accidents, alcohol-related problems and biomarkers of impulsivity

Effects of Photoperiod on Acetaminophen-Induced Hepatotoxicity in Mice

How have our clocks evolved? Adaptive and demographic history of the out-of-African dispersal told by polymorphic loci in circadian genes

Contact Info

Product

Resources

About