Associations between clinical characteristics and angiotensin-converting enzyme gene insertion/deletion polymorphism in Moroccan population with Type-2 diabetic nephropathy

Mansouri, Maria; Zniber, Amal; Boualla, Lamia; Badaoui, Ghizlane El; Benkacem, Mariam; Rifai, Kaoutar; Chraibi, A.; Benamar, L.; Sefiani, Abdelaziz; Bayahia, R.

doi:10.4103/1319-2442.202792

Cited by 5 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent data indicate that morbidity and mortality among diabetic patients are increased [ 14 ]. One severe complication of T2DM is type 2 diabetic nephropathy (T2DN), which is characterized by hypertension, albuminuria, and a progressive decline in glomerular filtration rate, developing into end-stage renal disease [ 17 , 18 ]. There is increasing evidence showing that TGF-β1 takes part in the pathogenesis of T2DN [ 19 – 21 ].…”

Section: Introductionmentioning

confidence: 99%

Relationship between transforming growth factor-β1 and type 2 diabetic nephropathy risk in Chinese population

Zhou

Zhong

et al. 2018

BMC Med Genet

View full text Add to dashboard Cite

BackgroundDiabetes mellitus (DM) is divided into four different etiological categories: type 1 DM (T1DM), type 2 DM (T2DM), other specific types, and gestational DM. One severe complication of T2DM is type 2 diabetic nephropathy (T2DN). The possible association of serum transforming growth factor-β1 (TGF-β1) levels and the TGF-β1 T869C gene polymorphism with patient susceptibility to T2DN in Chinese population is unclear at present. This study was conducted to assess these relationships in Chinese population by a meta-analysis.MethodsAssociation reports were searched and pulled from the Cochrane Library, the China Biological Medicine Database (CBM), and PubMed on March 1, 2018, and eligible studies were selected and used for calculations. The results were expressed as weighted mean differences (MD) for continuous data. Odds ratios (OR) were used to express the results for dichotomous data. Additionally, 95% confidence intervals (CI) were calculated.ResultsForty-eight reports for the relationship between serum TGF-β1 levels and the risk of T2DN and 13 studies on the association of the TGF-β1 T869C gene polymorphism with susceptibility to T2DN in Chinese population were retrieved from this study. Serum TGF-β1 levels in the T2DM group were higher than those in the normal control group (MD = 17.30, 95% CI: 12.69–21.92, P < 0.00001). The serum TGF-β1 level in the T2DN group was significantly higher than that in the normal control group (MD = 70.03, 95% CI: 60.81–79.26, P < 0.00001;). The serum TGF-β1 level in the T2DN group was significantly higher than that in the T2DM group (MD = 56.18, 95% CI: 46.96–65.39, P < 0.00001). Serum TGF-β1 levels in T2DM patients with microalbuminuria were increased when compared with those in T2DM patients with normoalbuminuria. Furthermore, serum TGF-β1 levels in T2DM patients with macroalbuminuria were increased when compared with those in T2DM patients with microalbuminuria. The TGF-β1 T allele, TT allele and CC genotype were associated with T2DN susceptibility in Chinese population (T: OR = 0.74, 95% CI: 0.59–0.92, P = 0.007; TT: OR = 0.55, 95% CI: 0.31–0.96, P = 0.04; CC: OR = 1.38, 95% CI: 1.14–1.67, P = 0.001).ConclusionsHigh levels of TGF-β1 are associated with susceptibility to T2DM, T2DN and the progression of proteinuria in T2DN patients in Chinese population. Further, the TGF-β1 T allele, and TT genotype were protective factors against the onset of T2DN and CC genotype was a risk factor for the susceptibility of T2DN in Chinese populations.

show abstract

Section: Introductionmentioning

confidence: 99%

Relationship between transforming growth factor-β1 and type 2 diabetic nephropathy risk in Chinese population

Zhou

Zhong

et al. 2018

BMC Med Genet

View full text Add to dashboard Cite

show abstract

“…Additionally, it was shown in the investigations by Mansouri et al [27] and Wyawahare et al [10] that there was no appreciable difference in the homozygous (DD) genotype between diabetic individuals with and without nephropathy.…”

Section: Discussionmentioning

confidence: 96%

Association between Angiotensin Converting Enzyme Gene I/D and Promoter Polymorphisms and Diabetic Nephropathy in Type2 Diabetic Patients in Ismailia, Egypt

Hassan,

Tolba,

Leheta

et al. 2023

Preprint

View full text Add to dashboard Cite

BACKGROUND: There is mounting evidence that the chronic activation of renal and systemic ACE, which results in the production of Angiotensin II, is a critical step in the pathogenesis of DN. Chronic ACE activation causes an increase in intraglomerular pressure, tissue damage, pro-inflammatory effects, and promotes fibrosis. AIM: The purpose of this study was to determine if ACE polymorphisms (I/D rs4646994 and promoter SNP, rs4292) and ACE level were related to the DN development in T2DM patients in the Egyptian community. PATIENTS AND METHODS: This study is designed as a case control study which enrolled 90 subjects divided into three groups: 30 diabetic patients without DN, 30 diabetic patients with DN and 30 healthy individuals as control group. We measured for each patient the following: serum creatinine, eGFR, ACR, lipid prolife, HbA1C, as well as serum ACE level. Genotyping of ACE I/D and promoter SNP, rs4292, polymorphisms in ACE gene were performed using conventional PCR assays. RESULTS: The laboratory data analysis revealed that the only variables across the trial groups that indicated a significant statistical difference were serum creatinine, eGFR, ACR, HDL-C, LDL-C, and HbA1c. Total cholesterol and triglycerides did not. Between the study groups, there was a substantial statistical difference in the level of serum ACE. In our population, the genotype and allele frequencies of the ACE I/D gene polymorphism varied considerably between research groups, suggesting that it may be a risk factor for DN. In comparison to individuals of the wild type (II), the (DD) genotype considerably raised the probability of progression to T2DM by about six times and of progression to DN by about ten folds. This study found that the ACE promoter rs4292 (C/T) polymorphism is a risk factor for developing DN. The (TT) genotype is associated with increased susceptibility to DN as it was higher in diabetic patients with nephropathy than the two other study groups. However, there was no statistically significant difference in the study variables among different genotypes subgroups. CONCLUSION:According to our research, the mutant alleles (T) of the ACE promoter rs4292 (C/T) polymorphism and the ACE I/D rs4646994 polymorphism may both be risk factors for DN in the Egyptian population.

show abstract

“…Diabetic nephropathy (DN) is one of the major microvascular complications of diabetes mellitus. 1 , 2 It is a multifactorial and polygenic disorder that occurs in a quarter to a third of all patients with prolonged diabetes mellitus and has been widely implicated as the leading cause of end-stage renal disease (ESRD). 3 Typically, the disease is diagnosed after significant damage has occurred to the kidney tissue.…”

Section: Introductionmentioning

confidence: 99%

Distribution of the ACE Gene Polymorphisms in Type 2 Diabetes Mellitus Patients, Their Associations with Nephropathy Biomarkers and Metabolic Indicators at a Tertiary Hospital in Uganda

Kiconco,

Kalyesubula,

Kiwanuka

2024

DMSO

View full text Add to dashboard Cite

Purpose We aimed at determining the distribution of the ACE insertion/deletion gene polymorphisms among type 2 diabetic patients and their association with the nephropathy biomarkers and the metabolic indicators. Patients and Methods Data were collected from 237 adult type 2 diabetes mellitus patients receiving healthcare at the diabetic clinic of Mbarara Regional Referral Hospital. Peripheral blood genomic DNA was amplified using a conventional PCR technique and analyzed for the ACE homozygous forms of the insertion (II), deletion (DD) and heterozygous insertion deletion (ID) genotypes as well as their respective allele counts. Biomarkers of nephropathy were analyzed on a Beckman coulter AU480 chemistry analyzer using system compatible reagents. Results Majority of the participants were older persons (Median = 57, IQR = 49–64) and female 171 (72.2%). Most of them had the Deletion allele 198 (83.5%) and DD genotype 116 (48.9%). At multivariate logistic regression, the nephropathy biomarkers that is microalbuminuria, serum creatinine, urea, eGFR and electrolytes had no association with the ACE I/D alleles or genotypes (p > 0.05). On the other hand, selected metabolic indicators had a positive relationship. The insertion allele was associated with increasing glycated hemoglobin (OR = 1.082, p = 0.019) and decreasing serum glucose levels (OR = 0.891, p = 0.001). Deletion allele was associated with decreasing glycated hemoglobin (OR = 0.924, p = 0.047) and increasing serum glucose levels (OR = 1.208, p = 0.001). ACE II genotype was associated with decreasing serum glucose levels (OR = 0.873, p = 0.029). ACE DD genotype was associated with decreasing glycated hemoglobin (OR = 0.917, p = 0.010) and increasing serum glucose levels (OR = 1.132, p = 0.001). ACE ID genotype was associated with increasing glycated hemoglobin (OR = 1.077, p = 0.022), triglyceride levels (OR = 1.316, p = 0.031) and decreasing serum glucose levels (OR = 0.933, p = 0.038). Conclusion The presence or absence of the ACE I/D alleles and genotypes affects the ultimate increase or decrease in the serum glucose, glycated hemoglobin and triglyceride levels. Although there was no significant association between the biomarkers of nephropathy and the ACE I/D alleles or genotypes, the above implicated metabolic indicators should be included in healthcare guidelines used when attending to type 2 diabetic patients.

show abstract

Associations between clinical characteristics and angiotensin-converting enzyme gene insertion/deletion polymorphism in Moroccan population with Type-2 diabetic nephropathy

Cited by 5 publications

References 0 publications

Relationship between transforming growth factor-β1 and type 2 diabetic nephropathy risk in Chinese population

Relationship between transforming growth factor-β1 and type 2 diabetic nephropathy risk in Chinese population

Association between Angiotensin Converting Enzyme Gene I/D and Promoter Polymorphisms and Diabetic Nephropathy in Type2 Diabetic Patients in Ismailia, Egypt

Distribution of the ACE Gene Polymorphisms in Type 2 Diabetes Mellitus Patients, Their Associations with Nephropathy Biomarkers and Metabolic Indicators at a Tertiary Hospital in Uganda

Contact Info

Product

Resources

About