Associations between cognitive function, metabolic factors and depression: A prospective study in Quebec, Canada

Ferri, Floriana; Deschênes, Sonya S.; Power, Niamh; Schmitz, N.

doi:10.1016/j.jad.2021.01.039

Cited by 19 publications

(11 citation statements)

References 52 publications

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“…Hence, the tremendous joint effects of life-course disadvantages and unhealthy lifestyles and the dilution effects of healthy lifestyles on depression can be comprehended. Furthermore, either shorter or longer sleep is significantly associated with cognitive decline and metabolic abnormalities that are prevalent in the elderly and may further contribute to depression 39-41 , which may help explain the most effective effects of reasonable sleep in our results. To the best of our knowledge, this is the first large-scale population-based study to investigate the association of life-course disadvantages and multiple lifestyles with depression in middle-aged and older Chinese.…”

Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 72%

“…The copyright holder for this this version posted September 14, 2022. ; https://doi.org/10.1101/2022.09.14.22279926 doi: medRxiv preprint abnormalities that are prevalent in the elderly and may further contribute to depression [39][40][41] , which may help explain the most effective effects of reasonable sleep in our results.…”

Section: Discussionmentioning

confidence: 79%

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The dilution effects of healthy lifestyles on the risk of depression attributed to life-course disadvantages among Chinese middle-aged and older adults

Ren

Lian

et al. 2022

Preprint

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Background: Life-course disadvantages and unhealthy lifestyles are well-known to independently induce depression, but their joint effects on depression and whether adopting healthy lifestyles can dilute the depressive risks attributed to life-course disadvantages remain unknown in China. Methods: Data were from the China Health and Retirement Longitudinal Study. Life-course (childhood and adulthood) disadvantages were defined using 60 questions and were classified as mild, moderate, and severe by principal component analysis. Healthy lifestyles, including regular exercise, reasonable sleep, never smoking, and no heavy alcohol consumption, were classified as 0/1, 2, 3, and 4. Depression was assessed using CESD-10 with cutoff ≥10. Logistic regression was used to investigate the association of life-course disadvantages and lifestyles with depression and the dilution effects of healthy lifestyles on the depressive risks attributed to life-course disadvantages. Results: Among 5724 participants included, sleep and smoking mediated 5.1% and 1.1% the effect of severe life-course disadvantages on depression while exercise mediated -0.8%. Multiple (vs. 0/1) healthy lifestyles were associated with decreased depressive risks more significantly as the life-course disadvantages increased, with odds ratios (ORs) and 95% confidence intervals (CIs) of 0.44 (0.25-0.80) and 0.33 (0.21-0.53) for 4 healthy lifestyles in participants with mild and severe life-course disadvantages, respectively. Compared to participants with mild life-course disadvantages and 4 healthy lifestyles, those who with severe life-course disadvantages and less than one lifestyles were more than 10 times as significantly associated with depression. Finally, participants with mild/moderate life-course disadvantages but ≤2 healthy lifestyles (vs. severe but 4 lifestyles) were not associated with decreased depressive risks. Conclusion: Adopting multiple healthy lifestyles can well-dilute the depressive risks attributed to life-course disadvantages in middle-aged and older Chinese, which is of great importance for reducing the depressive burden and the construction of healthy aging in China.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 72%

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The dilution effects of healthy lifestyles on the risk of depression attributed to life-course disadvantages among Chinese middle-aged and older adults

Ren

Lian

et al. 2022

Preprint

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“…The g-factor at wave 7 ranged between − 4.22 and 3.36. This approach has previously been used to examine cognitive function assessed by several tasks, in ELSA [40][41][42] and in other cohort studies [43][44][45].…”

Section: Cognitive Functionmentioning

confidence: 99%

Adverse childhood experiences and cognitive function in adulthood: examining the roles of depressive symptoms and inflammation in a prospective cohort study

Lowry

Schmitz

Deschênes

2022

Soc Psychiatry Psychiatr Epidemiol

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Purpose Adverse childhood experiences (ACEs) have been associated with cognitive decline in adulthood. However, the underlying mechanisms implicated remain unclear. This study investigated depressive symptoms and systemic inflammation as potential mediators of the association between ACEs and later cognitive function. Methods Participants were adults aged 50 + from the English Longitudinal Study of Ageing (N = 3029; 54.8% female). Measures included self-reported ACEs at wave 3 (2006–2007), C-reactive protein (CRP) and depressive symptoms at wave 4 (2008–2009), and cognitive function at waves 3 and 7 (2014–2015). Mediation analyses examined the direct associations between ACEs and cognitive function at wave 7 and the indirect associations via depressive symptoms and CRP at wave 4. In a first set of analyses, models were adjusted for sociodemographic factors and baseline cognitive function. In a second set of analyses, models were additionally adjusted for BMI and health behaviours (n = 1915). Results Cumulative ACEs exposure positively predicted depressive symptoms (b = 0.184, s.e. = 0.034, p < .001), which in turn predicted poorer cognitive function at wave 7 (b = − 0.035, s.e. = 0.008, p < .001). ACEs also positively predicted systemic inflammation as measured by CRP (b = 0.031, s.e. = 0.01, p = 0.0016). However, CRP did not mediate the association between ACEs and later cognitive function (b = − 0.0002, 95% CI: − 0.002, 0.002). Conclusion These findings suggest that ACEs may be related to cognitive decline partly via depressive symptoms and corroborate prior research linking ACEs with systemic inflammation in adulthood.

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“…However, evidence showed that not all people with psychiatric disorders display metabolic impairments due to age and gender are the most significant factors influencing the relationship between metabolism and mental disorder. For instance, metabolic conditions (abdominal obesity, high triglyceride, and glucose levels) are associated with an increased risk of a future depressive episode in middle-aged adults ( 3 ). Moreover, therapeutic targeting of metabolic parameters might provide new insights into the beneficial effects in depressed patients with high Body Mass Index (BMI) ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Serum Lipid Concentrations Are Associated With Negative Mental Health Outcomes in Healthy Women Aged 35–49 Years

Zhang

Li³

et al. 2021

Front. Psychiatry

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Background: Although the relevant underlying biological mechanisms are still lacking, mental disorders have been closely associated with several metabolic abnormalities including high rates of obesity and metabolic syndrome especially in vulnerable populations. Therefore, the current study aims to examine how metabolic parameters increase the risk for developing mood disorders in individuals stratified by gender and age.Methods: In a routine physical examination, 319 healthy participants were recruited and assigned to six different groups according to age (young adults: 25–34 Y, middle age: 35–49 Y, and older age: 50–65 Y) in both males and females. A linear regression and bivariate correlation analysis were used to analyze the relationship between mood health outcomes measured by the Kessler 10 Psychological Distress Scale (K10) and the metabolic function.Results: The results demonstrated that there was a significant association between K10 scores and metabolic parameters, including Body Mass Index (BMI), total-, LDL-cholesterol, and triglyceride. Furthermore, poor mental health (higher K10 scores) was observed in individuals with increased BMI, total-, LDL-cholesterol, and triglyceride levels particularly in middle-aged women relative to other groups.Limitations: This is a cross-sectional study with a small sample size and lacks longitudinal follow-up evidence and preventive interventions and therefore could not provide the causal inference of metabolic pathophysiology on the increased sensitivity to mental disorders.Conclusions: The potential association suggests that targeting of the metabolic parameters might give us a better understanding of the underlying mechanisms of psychiatric diseases and provide preventive strategies and potential treatment for those with metabolic disturbances especially in middle-aged females.

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Associations between cognitive function, metabolic factors and depression: A prospective study in Quebec, Canada

Cited by 19 publications

References 52 publications

The dilution effects of healthy lifestyles on the risk of depression attributed to life-course disadvantages among Chinese middle-aged and older adults

The dilution effects of healthy lifestyles on the risk of depression attributed to life-course disadvantages among Chinese middle-aged and older adults

Adverse childhood experiences and cognitive function in adulthood: examining the roles of depressive symptoms and inflammation in a prospective cohort study

Serum Lipid Concentrations Are Associated With Negative Mental Health Outcomes in Healthy Women Aged 35–49 Years

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