Associations Between Collagen Synthesis and Degradation and Aortic Function in Arterial Hypertension

Abstract

Alterations in collagen turnover that favor collagen type I synthesis; as well as proMMP-1 expression are related to increased aortic stiffness in treated hypertensive individuals without left ventricular (LV) hypertrophy.

Plasma levels of matrix metalloproteinases and their inhibitors in hypertension

“…In two studies, data of hypertensive patients were combined [28,39]. Five studies provided plasma MMP-1 levels [21,31,32,35,40]; the SMD between 305 hypertensive patients and 323 controls was 0 units [95% confidence interval (CI) À1.48, 1.48], not statistically significant. Sensitivity analysis excluding the studies with different mean age between groups and the studies in which age was not stated provided similar results.…”

Arterial stiffness is associated with adipokine dysregulation in non-hypertensive obese mice

“…Moreover, alterations in collagen turnover that favor type I collagen synthesis are also related to a decreased aortic elasticity 47,48 . Fibrillar type I/III collagens are the most abundant in vascular walls 49 and they play an important contribution to the rigidity of the arterial wall of resistance arteries in hypertension 6,9,31,50 .…”

Insights into the Activity, Differential Expression, Mutual Regulation, and Functions of Matrix Metalloproteinases and A Disintegrin and Metalloproteinases in Hypertension and Cardiac Disease

“…There have been many studies in humans evaluating the levels of MMPs and ADAMs in the systemic circulation during hypertension and left ventricular hypertrophy, as well as heart failure [84,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130]. A meta-analysis of these studies concluded that elevation of MMP-2 and MMP-9 can be used as plasma biomarkers for cardiovascular remodeling in hypertension [131].…”