Associations Between Composite Dietary Antioxidant Index and Gout: National Health and Nutrition Examination Survey 2007–2018

Abstract

Introduction: To explore the relationship between the composite dietary antioxidant index (CDAI) and gout to provide support for preventing gout through dietary intervention. Methods: Eligible participants from the 2007 to 2018 National Health and Nutrition Examination Survey aged 20 years and older were included in this cross-sectional study. The weighted chi-square test was used to compare the categorical variables difference between CDAI quartiles groups. The weighted univariate and binary logistic regression analysis were used to test the association between variables and gout. The weighted multivariable logistic regression was used to test the association of CDAI and gout in 4 different models. Subgroup analysis on the associations of CDAI with gout was conducted with stratified factors. Results: The final participants were 26,117, 13,103 (50.17%) were female, 8718 (33.38%) were 40–59 years, 11,200 (42.88%) were white and 1232 (4.72%) had gout. After adjusting for all covariates, the CDAI was associated with gout (odds ratio (OR), .97; 95% CI: .95–1.00). Participants in the highest CDAI quantile group were at low risk of gout (odds ratio (OR), .65; 95% CI: .50–.84) versus those in the lowest quantile group. Subgroup analysis and interaction test showed no significant dependence on diabetes mellitus (DM), marital status, alcohol status, hypertension, poverty income ratio (PIR), education level, body mass index (BMI), smoke status, age, sex, race, and chronic kidney disease (CKD) on this association (all p for interaction >.05). Conclusions: Composite dietary antioxidant index was inversely associated with gout in US adults, and dietary antioxidant intervention might be a promising method in the therapy of gout and greater emphasis should be placed on zinc, selenium, carotenoids, vitamins A, C, and E.

Association Between Composite Dietary Antioxidant Index and the Risk of Endometriosis-Related Rheumatoid Arthritis in Women of Childbearing Age: A Cross-Sectional Study Based on the National Health and Nutrition Examination Survey Database

“…A study using data from the NHANES database reported that CDAI was inversely associated with gout in US adults. 23 Results from the Singapore Chinese Health Study indicated that an elevated CDAI correlated with a reduced likelihood of colorectal cancer onset. 16 The research by Chen et al demonstrated a negative correlation between CDAI and diabetes incidence.…”

Association between composite dietary antioxidant index and hyperlipidemia: a cross-sectional study from NHANES (2005–2020)

“…This hypothesis was first confirmed in a cross-sectional study from Korea, where they found that dietary total antioxidant capacity (TAC) was associated with dyslipidemia (hypercholesterolemia, hypertriglyceridemia, and hypoHDL-cholesterolemia) 13 . The Composite Dietary Antioxidant Index (CDAI) was a nutritional tool developed to assess the overall antioxidant capacity of an individual's daily food intake 14 – 17 . It took into account six specific antioxidants, namely vitamin A, vitamin C, vitamin E, carotenoids, selenium, and zinc 14 – 17 , with a higher CDAI score indicating a dietary pattern rich in antioxidants.…”

“…The Composite Dietary Antioxidant Index (CDAI) was a nutritional tool developed to assess the overall antioxidant capacity of an individual's daily food intake 14 – 17 . It took into account six specific antioxidants, namely vitamin A, vitamin C, vitamin E, carotenoids, selenium, and zinc 14 – 17 , with a higher CDAI score indicating a dietary pattern rich in antioxidants. Though previous studies have confirmed the relationship between CDAI and several chronic diseases, hypertension 18 , diabetes mellitus 19 , coronary heart disease 20 .…”

Association between oxidative balance score and risk of gout: The NHANES cross‐sectional study, 2007–2018

“…Currently, a relationship between dietary antioxidant indices and gout has been demonstrated 14 . In addition to dietary factors, some lifestyle factors, including smoking, alcohol consumption, physical activity, and obesity, 15 are also have an impact on gout.…”

“…13 Currently, a relationship between dietary antioxidant indices and gout has been demonstrated. 14 In addition to dietary factors, some lifestyle factors, including smoking, alcohol consumption, physical activity, and obesity, 15 are also have an impact on gout. The Oxidative Balance Score (OBS) is a composite index of 20 different dietary and lifestyle components that highlights the overall balance of pro-oxidants and antioxidants at the dietary and lifestyle level.…”