Associations between Depressive Symptomatology and Neurocognitive Impairment in HIV/AIDS

Tymchuk, Sarah; Gomez, Daniela; Koenig, Noshin; Gill, M John; Fujiwara, Esther; Power, Christopher

doi:10.1177/0706743717737029

Cited by 22 publications

(24 citation statements)

References 59 publications

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“…Living-Modified (8-items) [31] Physical functioning [31,35,38,40,43,47] Level of independence Health status (Functional ability across 8 common daily, 'complex' tasks (Telephone use, Shopping, Food preparation, Housekeeping, Laundry, Transportation, Medication management and Financial management) ALF Questionnaire (9-items) [32] Physical functioning [32] Mental functioning Social functioning PHQ-9 (9-item) [44] Mental health [43,45,51] Beck Depression Inventory BDI-II (21-Item) [53] Mental health [32,40,50] Profile of Mood States POMS (65-items) [37] Mental wellbeing [35] https://doi.org/10.1371/journal.pone.0251944.t003…”

Section: Lawson and Brody Instrumental Activities Of Dailymentioning

confidence: 99%

Quality of life in people living with HIV-associated neurocognitive disorder: A scoping review study

et al. 2021

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Quality of life (QoL) is recognized as an essential end point in the disease management of chronic conditions such as HIV with calls to include good QoL as a ‘fourth 90’ in the 90-90-90 testing and treatment targets introduced by World Health Organization in 2016. Cognitive impairments impact a broad spectrum of experiences and are a common issue effecting people living with HIV (PLWH). Despite this, few studies have examined QoL in PLWH who also have a cognitive disorder. This study aimed to synthesize and describe what is known about QoL in those living with HIV-associated neurocognitive disorders (HAND). A scoping review of peer-reviewed literature was conducted to identify how QoL has been investigated and measured in PLWH with HAND, and how PLWH with HAND report and describe their QoL. We searched PsychInfo, Medline, Scopus, and Web of Science along with hand-searching reference lists from relevant studies found. Included studies were those published in English after 1st January 2003 which included PLWH with cognitive impairment not due to other pre-existing conditions. Fifteen articles met criteria for inclusion. Two studies measured QoL as a primary aim, with others including QoL assessment as part of a broader battery of outcomes. The MOS-HIV and SF-36 were the most commonly used measures of overall QoL, with findings generally suggestive of poorer overall QoL in PLWH with HAND, compared to PLWH without cognitive impairment. Studies which examined dimensions of QoL focused exclusively on functionality, level of independence, and psychological QoL domains. There is a considerable dearth of research examining QoL in PLWH with HAND. The initiatives which advocate for healthy aging and improved QoL in PLWH must be extended to include and understand the experiences those also living with cognitive impairment. Research is needed to understand the broad experiential impacts of living with these two complex, chronic conditions, to ensure interventions are meaningful to patients and potential benefits are not missed.

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Section: Lawson and Brody Instrumental Activities Of Dailymentioning

confidence: 99%

Quality of life in people living with HIV-associated neurocognitive disorder: A scoping review study

et al. 2021

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“…[4567] Depression is reported in up to 45% of HIV/AIDS patients. [8] Bhargav et al . [9] have reported that yoga could promote the health of HIV-infected mothers, enhance the efficacy of antiretroviral therapy (ART) in preventing vertical progression of HIV (mother-to-child transmission of HIV), and help reduce ART-related side effects.…”

Section: Introductionmentioning

confidence: 99%

Effect of yoga on immune parameters, cognitive functions, and quality of life among HIV-positive children/adolescents: A pilot study

2019

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Context: HIV/AIDS individuals have problems relating to immune system, quality of life (QOL), and cognitive functions (CFs). Yoga is found to be useful in similar conditions. Hardly, any work is reported on yoga for HIV-positive adults/adolescents. Hence, this study is important. Aim: The aim of the study is to determine the effect of yoga on immune parameters, CFs, and QOL of HIV-positive children/adolescents. Settings and Design: Single-group, pre–post study with 4-month yoga intervention. Methods: The study had 18 children from an HIV/AIDS rehabilitation center for children/adolescents. CD4, CD8, CD4/CD8 ratio, and viral loads were studied. CF tests included six letter cancellation test, symbol digit modalities test, digit-span forward backward test, and Stroop tests. QOL was assessed using PedsQL-QOL and fatigue questionnaire. Depression was assessed using CDI2-SR. Statistical Analysis Used: t -test and Wilcoxon signed-rank tests, as applicable. Results: The study included 18 children/adolescents. There was improvement in general health of the participants. There was statistically significant increase in CD4 cells counts ( p = 0.039) and significant decrease in viral load ( p = 0.041). CD4/CD8 ratio moved to normal range. QOL significantly improved. CFs had mixed results with improved psychomotor performance (PP) and reduced executive functions. Conclusions: There was improvement in general health and immune parameters. While depression increased, QOL improved. CFs showed mixed results with improved PP and reduced executive functions.

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“…Pre-HIV history of substance use, depressive, or bipolar disorder is common in patients with HIV disease and can increase risk of HAND (Atkinson et al, 2009;Weber et al, 2013). These findings are particularly relevant for older PLWH, as depressive disorders in this group may directly lead to impaired function irrespective of separately diagnosed neurocognitive disorders and can complicate the management of neurocognitive disorders (Owora, 2018;Tymchuk et al, 2018;Cross et al, 2013). In addition, in older patients, depressive disorders may primarily present with significant cognitive complaints, which can improve with antidepressant treatment.…”

Section: Introductionmentioning

confidence: 99%

Functional deficits and other psychiatric associations with abnormal scores on the Montreal Cognitive Assessment (MoCA) in older HIV-infected patients

Bourgeois

John

Greene

et al. 2019

Int. Psychogeriatr.

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Objective:The authors assessed the association of physical function, social variables, functional status, and psychiatric co-morbidity with cognitive function among older HIV-infected adults.Design:From 2012–2014, a cross-sectional study was conducted among HIV-infected patients ages 50 or older who underwent comprehensive clinical geriatric assessment.Setting:Two San Francisco HIV clinics.Participants:359 HIV-infected patients age 50 years or olderMeasurementsUnadjusted and adjusted Poisson regression measured prevalence ratios and 95% confidence intervals for demographic, functional and psychiatric variables and their association with cognitive impairment using a Montreal Cognitive Assessment (MoCA) score < 26 as reflective of cognitive impairment.ResultsThirty-four percent of participants had a MoCA score of < 26. In unadjusted analyses, the following variables were significantly associated with an abnormal MoCA score: born female, not identifying as homosexual, non-white race, high school or less educational attainment, annual income < $10,000, tobacco use, slower gait speed, reported problems with balance, and poor social support. In subsequent adjusted analysis, the following variables were significantly associated with an abnormal MoCA score: not identifying as homosexual, non-white race, longer 4-meter walk time, and poor social support. Psychiatric symptoms of depressive, anxiety, and post-traumatic stress disorders did not correlate with abnormal MoCA scores.Conclusions:Cognitive impairment remains common in older HIV-infected patients. Counter to expectations, co-morbid psychiatric symptoms were not associated with cognitive impairment, suggesting that cognitive impairment in this sample may be due to neurocognitive disorders, not due to other psychiatric illness. The other conditions associated with cognitive impairment in this sample may warrant separate clinical and social interventions to optimize patient outcomes.

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Associations between Depressive Symptomatology and Neurocognitive Impairment in HIV/AIDS

Cited by 22 publications

References 59 publications

Quality of life in people living with HIV-associated neurocognitive disorder: A scoping review study

Quality of life in people living with HIV-associated neurocognitive disorder: A scoping review study

Effect of yoga on immune parameters, cognitive functions, and quality of life among HIV-positive children/adolescents: A pilot study

Functional deficits and other psychiatric associations with abnormal scores on the Montreal Cognitive Assessment (MoCA) in older HIV-infected patients

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