Associations between dietary patterns and dementia‐related neuroimaging markers

Samuelsson, Jessica; Marseglia, Anna; Lindberg, Olof; Westman, Eric; Pereira, Joana B.; Shams, Sara; Kern, Silke; Ahlner, Felicia; Rothenberg, Elisabet; Skoog, Ingmar; Zettergren, Anna

doi:10.1002/alz.13048

Cited by 3 publications

(1 citation statement)

References 65 publications

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“…The beneficial effects of the MeDi in preventing brain atrophy have been demonstrated [ 4 ], and cross-sectional studies have shown that, among older adults, adherence to the MeDi is associated with larger brain volume [ 5 ], greater cortical thickness [ 6 , 7 ], and better white matter (WM) microstructural integrity [ 8 ]. A longitudinal cohort study conducted in older Scottish individuals showed that lower adherence to the MeDi predicted total brain atrophy during a 3-year period [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Associations of dietary patterns and longitudinal brain-volume change in Japanese community-dwelling adults: results from the national institute for longevity sciences-longitudinal study of aging

Zhang,

Sala,

Nakamura

et al. 2024

Nutr J

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Background The association of dietary patterns and longitudinal changes in brain volume has rarely been investigated in Japanese individuals. We prospectively investigated this association in middle-aged and older Japanese community-dwelling adults. Methods Data with a 2-year follow-up from the sixth wave (July 2008 to July 2010; baseline) to the seventh (July 2010 to July 2012; follow-up) of the National Institute for Longevity Sciences-Longitudinal Study of Aging project were analyzed. Dietary intake was assessed using a 3-day dietary record, and longitudinal volume changes (%) in the total gray matter (TGM), total white matter, and frontal, parietal, occipital, temporal, and insular lobes were assessed using 3-dimensional T1 magnetic resonance imaging scans. Multiple factor analysis and hierarchical clustering revealed sex-specific dietary patterns. Associations between dietary patterns and annual brain-volume changes (%) were evaluated using general linear models adjusted for age, apoprotein E genotype, body mass index, medical history, lifestyle behaviors, socioeconomic factors, and energy intake. Results Among the 1636 participants (age: 40.3–89.2 years), three dietary patterns were determined for men (n = 815; Western; Vegetable-Fruit-Dairy; and Traditional Japanese diets) and women (n = 821; Western; Grain-Vegetable-Fruit; and Traditional Japanese diets). Compared to women following the Western diet, those on the Traditional Japanese diet had less TGM atrophy. Multivariable-adjusted β (95% confidence interval) of the annual change (%) of TGM was − 0.145 (-0.287 to -0.002; P = 0.047), which correlated with reduced parietal lobe atrophy. No association between dietary pattern and brain atrophy was observed in men. Conclusions Adherence to healthy dietary patterns, with higher consumption of whole grains, seafood, vegetables, fruits, mushrooms, soybean products, and green tea, potentially confers a protective effect against brain atrophy in middle-aged and older Japanese women but not in men. Further research to confirm these results and ascertain the underlying mechanisms is required. This study highlights the importance of sex-specific effects on the relationship between dietary patterns and brain health in diverse populations.

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Section: Introductionmentioning

confidence: 99%

Associations of dietary patterns and longitudinal brain-volume change in Japanese community-dwelling adults: results from the national institute for longevity sciences-longitudinal study of aging

Zhang,

Sala,

Nakamura

et al. 2024

Nutr J

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Vascular cognitive impairment – Past, present, and future challenges

Badji,

Youwakim,

Cooper

et al. 2023

Ageing Research Reviews

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Association of Gum Treatment with Cognitive Decline and Dementia Risk among Older Adults with Periodontal Symptoms: A 12-Year Prospective Cohort Study

Qi,

Zhu,

Wang

et al. 2024

Neuroepidemiology

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Introduction: This study examines the associations of gum treatment with cognitive decline and dementia risk among older adults with periodontal symptoms in the US. Methods: A cohort of 866 adults aged ≥50 with periodontal symptoms was recruited for the 2008 Health and Retirement Study “Dental Health Experimental Module” and followed until 2020. Cognitive function was assessed with the Telephone Interview for Cognitive Status (TICS). Dementia status was ascertained with the Langa-Weir algorithm based on TICS scores and proxy assessments. Linear mixed-effects model and multivariable Cox regression models were utilized to analyze the associations of gum treatment with cognitive decline and the risk of dementia, respectively. Results: Of 866 participants (mean age 67.7, 61.4% women), 105 (12.1%) developed dementia with a median 9 (IQR, 6-10) years follow-up. The dementia incidence rates were lower in the group with gum treatment (7.4 vs. 12.9 per 1,000 person-years). Compared with participants who did not have gum treatment, those with gum treatment experienced a decline in TICS score that was on average 0.025 (95% CI, 0.005-0.044) points less per year and a 38% lower incidence of dementia (Hazard Ratio, 0.62; 95% CI, 0.41-0.93). These associations were consistent across participants with different severity of periodontal symptoms and sociodemographic characteristics (age, sex, race, ethnicity, and education) except for income levels. Conclusion: Prompt gum treatment for older adults with periodontal symptoms may be beneficial for their cognitive health.

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Associations between dietary patterns and dementia‐related neuroimaging markers

Cited by 3 publications

References 65 publications

Associations of dietary patterns and longitudinal brain-volume change in Japanese community-dwelling adults: results from the national institute for longevity sciences-longitudinal study of aging

Associations of dietary patterns and longitudinal brain-volume change in Japanese community-dwelling adults: results from the national institute for longevity sciences-longitudinal study of aging

Vascular cognitive impairment – Past, present, and future challenges

Association of Gum Treatment with Cognitive Decline and Dementia Risk among Older Adults with Periodontal Symptoms: A 12-Year Prospective Cohort Study

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