Associations Between Early Implant Failure, Patient Age, and Patient Mortality: A 15-Year Follow-Up Study on 2,566 Patients Treated with Implant-Supported Prostheses in the Edentulous Jaw

Jemt, Torsten; Nilsson, Mats; Olsson, Malin; Stenport, Victoria Franke

doi:10.11607/ijp.4933

Cited by 35 publications

(66 citation statements)

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“…[30][31][32][33] It has also been reported that the early onset of osteoarthritis in young patients which has resulted in total hip or knee replacement has shown similar observations with respect to an increased risk of CVD and increased mortality. [34][35][36] As observed for the present edentulous patients, 11,28,29 orthopedic implant patients also showed a decreased risk of mortality with increasing age at the time of hip/knee surgery. 34,35 Accordingly, patients provided with oral as well as with knee and hip implants all seem to present a similar pattern related to early inflammation-driven problems such as the following: severe arthritis or periodontitis; early implant placement in the hip, knee or oral region; higher risk of CVD; and early mortality.…”

Section: Discussionsupporting

confidence: 78%

“…26 The edentulous patients in the present clinic with an early event of implant treatment have been further analyzed and shown to present a higher risk of CVD and early mortality. 11,28,29 Additionally, other studies have shown an increased risk of CVD and/or early mortality in relation to periodontitis, tooth loss, and edentulism. [30][31][32][33] It has also been reported that the early onset of osteoarthritis in young patients which has resulted in total hip or knee replacement has shown similar observations with respect to an increased risk of CVD and increased mortality.…”

Section: Discussionmentioning

confidence: 98%

“…[1][2][3][4][5][6][7][8][9] However, in a recent series of publications based on multivariable statistical analyses, large homogeneous groups of patients have shown a significant linear association between age at surgery and implant failures. [10][11][12][13][14][15] It was also reported that these young edentulous patients have not only shown an increased risk of failures during the early period of follow-up, but they have also presented a higher risk than older patients over 10 to 15 years of follow-up. [10][11][12][13][14][15] It was also reported that these young edentulous patients have not only shown an increased risk of failures during the early period of follow-up, but they have also presented a higher risk than older patients over 10 to 15 years of follow-up.…”

Section: Introductionmentioning

confidence: 99%

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Implant failures and age at the time of surgery: A retrospective study on implant treatment in 2915 partially edentulous jaws

Jemt

2019

Clin Implant Dent Rel Res

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Purpose: To further report and analyze data on the prevalence of implant failures related to age at surgery in partially edentulous jaws.Materials and Methods: Altogether, 2915 partially edentulous jaws (Kennedy Class I and II) were consecutively treated with 9167 implants over a 30-year period (1986-2015) in one referral clinic. All implant failures were consecutively recorded and the first event of implant failure was analyzed in relation to patient age at implant surgery.Results: A total of 2453 patients participated in the study. The main observations were a nonlinear, normal distribution association between risk of implant failure and age at surgery with the highest risk in middle-aged patients. The risk for implant failures was significantly higher for middle-aged patients (45-64 years) than for old patients at the time of surgery (P < .05). The overall cumulative survival rates for treated jaws increased consistently from the age group of 40 to 49 years to that of >79 years. However, younger age groups (<40 years) presented a different pattern.Partially edentulous patients included late in the study (2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015) presented a more pronounced nonlinear, normal distribution, and the highest risk of implant failure in patients between 50 and 55 years of age at surgery.Conclusions: An overall nonlinear risk pattern of implant failure was observed, with the highest risk in the middle-aged group at implant surgery. Overall cumulative survival rates were highest in the youngest and oldest age groups at implant surgery, and this pattern became more pronounced in patients included late in the study.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Implant failures and age at the time of surgery: A retrospective study on implant treatment in 2915 partially edentulous jaws

Jemt

2019

Clin Implant Dent Rel Res

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“…15 This finding could have arisen because old and very fragile edentulous patients have been treated with implants in low numbers, and because only healthy old patients are treated; therefore, lower mortality is observed than in the normal population. 23,29,31 Patients with "an early onset of osteoarthritis of the knee which has been treated by total knee replacement is linked to an increased mortality" associated with increased risk of CVD, 32 which is a similar pattern to what could be observed in young edentulous patients provided with implants. This finding could indicate that young edentulous patients might face greater challenges in maintaining implants as they grew older than would old healthy patients with implants ( Figure 7).…”

Section: Discussionmentioning

confidence: 76%

“…28 It was during the early period of osseointegration discussed that age at surgery was a potential risk factor for implant treatment such that increasing age at surgery was associated with more osteoporotic bone and other age-related systemic risk factors. 23,29 Thus, the data indicate that the risk of implant failures is higher not only for young patient during osseointegration but also for the following 15 years after treatment ( Figure 7). 15 This finding could have arisen because old and very fragile edentulous patients have been treated with implants in low numbers, and because only healthy old patients are treated; therefore, lower mortality is observed than in the normal population.…”

Section: Discussionmentioning

confidence: 92%

Implant failures and age at the time of surgery: A retrospective study on implant treatments in 4585 edentulous jaws

Jemt

2019

Clin Implant Dent Rel Res

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Background: There is limited knowledge on the relationship between implant failures and patient age at implant surgery.Purpose: To further analyze and report long-term data on previously presented significant associations between implant failures and age at surgery in patients receiving treatment in the edentulous jaw. Materials and Methods:A total of 4049 patients were provided with 24 781 implants during 4585 operations in edentulous jaws between 1986 and 2015 in one referral clinic. Patients were thereafter invited to be followed up until the termination of the study. All implant failures were recorded, and nonlinear spline statistical methods and calculations of survival curves for different age groups were used to analyze implant failures related to age at surgery.Results: Ten-year age groups presented consistently higher overall survival rates with increasing age. The overall 10-year survival rates for treated jaws without failures ranged between 83.4% and 91.0% for different age groups. The risk of implant failures in 50-year-old patients was higher than in older patients within 15 years of follow-up (66/78 years; P < 0.05). The difference between young (<45 years), middle-aged (45-64 years), and old (>64 years) patients became more pronounced in patients included later in the study (2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015).Conclusions: Young edentulous patients presented an overall significantly higher risk of implant failure than did old patients. The risk decreased consistently from patients in the youngest age group (30-39 years) to those in the oldest age group (>79 years), with a more pronounced pattern for the patients included in the late period. This finding suggests a change in patient characteristics during the time of inclusion, but no causal explanations for the present observations have been established. K E Y W O R D Sage, complication, dental implants, follow-up, implant failure, incidence, interpretation bias

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An osteogenic magnesium alloy with improved corrosion resistance, antibacterial, and mechanical properties for orthopedic applications

Aboutalebianaraki

Zeblisky

Sarker

et al. 2022

J Biomedical Materials Res

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The aim of this study was to develop a novel biodegradable magnesium (Mg) alloy for bone implant applications. We used scandium (Sc; 2 wt %) and strontium (Sr; 2 wt %) as alloying elements due to their high biocompatibility, antibacterial efficacy, osteogenesis, and protective effects against corrosion. In the present work, we also examined the effect of a heat treatment process on the properties of the Mg‐Sc‐Sr alloy. Alloys were manufactured using a metal casting process followed by heat treatment. The microstructure, corrosion, mechanical properties, antibacterial activity, and osteogenic activity of the alloy were assessed in vitro. The results showed that the incorporation of Sc and Sr elements controlled the corrosion, reduced the hydrogen generation, and enhanced mechanical properties. Furthermore, alloying with Sc and Sr demonstrated a significantly enhanced antibacterial activity and decreased biofilm formation compared to control Mg. Also, culturing Mg‐Sc‐Sr alloy with human bone marrow‐derived mesenchymal stromal cells showed a high degree of biocompatibility (>90% live cells) and a significant increase in osteoblastic differentiation in vitro shown by Alizarin red staining and alkaline phosphatase activity. Based on these results, the Mg‐Sc‐Sr alloy heat‐treated at 400°C displayed optimal mechanical properties, corrosion rate, antibacterial efficacy, and osteoinductivity. These characteristics make the Mg‐Sc‐Sr alloy a promising candidate for biodegradable orthopedic implants in the fixation of bone fractures such as bone plate‐screws or intramedullary nails.

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Associations Between Early Implant Failure, Patient Age, and Patient Mortality: A 15-Year Follow-Up Study on 2,566 Patients Treated with Implant-Supported Prostheses in the Edentulous Jaw

Cited by 35 publications

References 0 publications

Implant failures and age at the time of surgery: A retrospective study on implant treatment in 2915 partially edentulous jaws

Implant failures and age at the time of surgery: A retrospective study on implant treatment in 2915 partially edentulous jaws

Implant failures and age at the time of surgery: A retrospective study on implant treatments in 4585 edentulous jaws

An osteogenic magnesium alloy with improved corrosion resistance, antibacterial, and mechanical properties for orthopedic applications

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