Associations Between Event-Related Potentials and Measures of Attention and Inhibition in the Continuous Performance Task in Children With ADHD and Normal Controls

Overtoom, C.C.E.; Verbaten, Marinus N.; Kemner, Chantal; Kenemans, J. Leon; Engeland, Hermán van; Buitelaar, Jan K.; Camfferman, Gert; Koelega, Harry S.

doi:10.1097/00004583-199809000-00018

Cited by 124 publications

(109 citation statements)

References 26 publications

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“…In addition, none of the interactions were significant. The absence of an amplitude difference for the no-go trials was surprising and contrasted with previous tasks involving response inhibition ( Jackson et al, 1999;Overtoom et al, 1998;Eimer, 1993). A possible explanation for our failure to detect the expected amplitude differences in the N2 is that propagation of the P3 seems to have reduced our ability to detect the N2 in response to this task.…”

Section: N2contrasting

confidence: 67%

“…Several studies using similar tasks have reported greater amplitude of the N2 in response to trials requiring inhibition of a motor response ( Jackson et al, 1999;Overtoom et al, 1998;Eimer, 1993). Although the reason for the null finding in this study is unclear, it should be noted that the task differed from the tasks previously used in ERP studies in multiple ways, such as task complexity and target/non-target ratio.…”

Section: Discussionmentioning

confidence: 56%

“…One possibility may be that, although the P3 reflects a similar cognitive process for adults and children, children deployed this cognitive resource for both the Block 2 go and no-go trials and adults did not. It has been proposed that the amplitude of the P3 at parietal sites reflects the degree of task relevance or attention to the stimuli (Tekok-Kilic et al, 2001;Keifer et al, 1998;Overtoom et al, 1998). For adults, greater amplitude of the P3 for the no-go trials may suggest that these trials were more relevant and required more processing resources than the other trials.…”

Section: Discussionmentioning

confidence: 99%

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The X-Trials: Neural Correlates of an Inhibitory Control Task in Children and Adults

Davis

Bruce

Snyder

et al. 2003

Journal of Cognitive Neuroscience

114

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Event-related potentials (ERPs) were used to examine developmental differences between adults and 6-year-old children in the neural processes involved in an inhibitory control task. Twenty adults and 21 children completed a task that required them to selectively respond to target stimuli while inhibiting responses to equally salient non-target stimuli. Because this task had been previously studied using functional magnetic resonance imaging (fMRI), the relation between the fMRI and ERP findings was informally examined. The results indicate that latency and amplitude of the P3 differentiated the different types of trials. However, the pattern of event-related neural activity differed for adults and children. These results, which suggest that adults and children may be using different processes to perform this task, have implications for the interpretation of the previous fMRI findings.

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Section: N2contrasting

confidence: 67%

Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The X-Trials: Neural Correlates of an Inhibitory Control Task in Children and Adults

Davis

Bruce

Snyder

et al. 2003

Journal of Cognitive Neuroscience

114

View full text Add to dashboard Cite

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“…Explicit analyses of Go-P3 evoked by the CPT in ADHD are rare, but some instances of diminished amplitude in patients have been observed [70,72,88,89].…”

Section: Psychophysiological Characteristicsmentioning

confidence: 99%

ADHD History of the Concept: the Case of the Continuous Performance Test

Albrecht

Sandersleben

Wiedmann

et al. 2015

Curr Dev Disord Rep

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The historic development of the attention deficit hyperactivity disorder (ADHD) construct is, in many cases, paralleled by research questions addressed with the continuous performance test (CPT). This task, the use of which dates back to the 1950s for the diagnosis of brain damage, requires responding to rare targets in a sequence of stimuli during prolonged assessment. In our review, we illustrate how the CPT was and still is used for the assessment of sustained attention and impulsivity as core features of ADHD. In addition to impaired performance at the neuropsychological level, the CPT also taps underlying brain activity that can be registered by neuroimaging techniques such as fMRI and EEG. The latter allows more detailed operationalization of ADHD theories, and reveals impairments at different stages of information processing. The CPT has also been applied for treatment evaluation. Recently, distinct genetic effects on preparation and response control or impulsivity were detected using the CPT. As such, the task remains a valuable tool for further investigations of genetic and environmental factors of ADHD.

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“…Explicit analyses of the Go-P3 in ADHD are rare, but some instances of diminished amplitude for patients have been seen (Strandburg et al 1996 ;Overtoom et al 1998 ;Banaschewski et al 2004 ;Lawrence et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Familiality of neural preparation and response control in childhood attention deficit-hyperactivity disorder

et al. 2012

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BACKGROUND: Patients with attention deficit-hyperactivity disorder (ADHD) exhibit difficulties in multiple attentional functions. Although high heritability rates suggest a strong genetic impact, aetiological pathways from genes and environmental factors to the ADHD phenotype are not well understood. Tracking the time course of deviant task processing using event-related electrophysiological brain activity should characterize the impact of familiality on the sequence of cognitive functions from preparation to response control in ADHD. Method Preparation and response control were assessed using behavioural and electrophysiological parameters of two versions of a cued continuous performance test with varying attentional load in boys with ADHD combined type (n = 97), their non-affected siblings (n = 27) and control children without a family history of ADHD (n = 43). RESULTS: Children with ADHD and non-affected siblings showed more variable performance and made more omission errors than controls. The preparatory Cue-P3 and contingent negative variation (CNV) following cues were reduced in both ADHD children and their non-affected siblings compared with controls. The NoGo-P3 was diminished in ADHD compared with controls whilst non-affected siblings were located intermediate but did not differ from both other groups. No clear familiality effects were found for the Go-P3. Better task performance was further associated with higher CNV and P3 amplitudes. CONCLUSIONS: Impairments in performance and electrophysiological parameters reflecting preparatory processes and to some extend also for inhibitory response control, especially under high attentional load, appeared to be familially driven in ADHD and may thus constitute functionally relevant endophenotypes for the disorder. Background. Patients with attention deficit-hyperactivity disorder (ADHD) exhibit difficulties in multiple attentional functions. Although high heritability rates suggest a strong genetic impact, aetiological pathways from genes and environmental factors to the ADHD phenotype are not well understood. Tracking the time course of deviant task processing using event-related electrophysiological brain activity should characterize the impact of familiality on the sequence of cognitive functions from preparation to response control in ADHD.

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Associations Between Event-Related Potentials and Measures of Attention and Inhibition in the Continuous Performance Task in Children With ADHD and Normal Controls

Cited by 124 publications

References 26 publications

The X-Trials: Neural Correlates of an Inhibitory Control Task in Children and Adults

The X-Trials: Neural Correlates of an Inhibitory Control Task in Children and Adults

ADHD History of the Concept: the Case of the Continuous Performance Test

Familiality of neural preparation and response control in childhood attention deficit-hyperactivity disorder

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