Associations between executive function impairment and biochemical abnormalities in depressed adolescents with non-suicidal self-injury

Zhang, Yiliang; Lai, Shunkai; Wu, Weige; Wang, Ying; Zhao, Hui; He, Jiali; Zhu, Yunxia; Chen, Guangmao; Qi, Zhangzhang; Chen, Pan; Lv, Sihui; Song, Zijin; Hu, Yi; Miao, Haofei; Yan, Suxia; Luo, Yong Ming; Ran, Hanglin; Huang, Xiaosi; Lü, Xiaodan; Zhong, Shuming; Jia, Yanbin

doi:10.1016/j.jad.2021.10.132

Cited by 13 publications

(9 citation statements)

References 60 publications

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“…Under the self-injury cue, the P3 amplitude of NSSI group was larger than that of HC group, and the P3 amplitude with the self-injury cue was significantly larger than that with the neutral cue, indicating that the neural response of NSSI adolescents changed during exposure to the self-injury cue ( Zhou et al, 2022 ). Allen found difficulty in response inhibition in the group of eating disorders with NSSI ( Allen et al, 2020 ), Nilsson also found that compared with healthy people ( Nilsson et al, 2021 ), patients with intentional self-mutilation had defects in cognitive flexibility and response inhibition, and Zhang also found executive dysfunction in the group of MDD adolescents with NSSI ( Zhang et al, 2022 ). Our study find neuroelectrophysiological evidence in the adolescent MDD with NSSI compared with HC.…”

Section: Discussionmentioning

confidence: 95%

Prefrontal cortex neural activity predicts reduction of non-suicidal self-injury in adolescents with major depressive disorder: An event related potential study

et al. 2022

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BackgroundNon-suicidal self-injury (NSSI) is common in adolescent MDD, which is also a risk factor for suicide. However, there is few research on biomarkers and predictors about treatment response of NSSI. The purpose of this study was to find the difference of P300 between adolescent MDD with NSSI and healthy controls, and to explore whether the baseline electrophysiological level can predict the change of NSSI after treatment.MethodsWe collected 62 first-episode drug-naïve MDD adolescents with NSSI (MDD with NSSI group) and 44 healthy controls (HC group). The demographic data, HAMD score, self-injury frequency and electrophysiological level of NSSI group and HC group were collected. The HAMD score, frequency of NSSI in was also collected after 8 weeks of antidepressant treatment.ResultsCompared to HC, the latency of the N2, P3a, and P3b components were significantly prolonged, whereas the amplitude of P3a and P3b were decreased in the MDD with NSSI group (P < 0.001). The frequency of self-injury decreased significantly after treatment (P < 0.001). Regression analysis showed that the amplitudes of P3b had a significant positive predictive effect on the rate of change of NSSI frequency after 8 weeks.ConclusionP3b at baseline can be used as potential predictor for the reduction of NSSI in adolescent MDD.

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Section: Discussionmentioning

confidence: 95%

Prefrontal cortex neural activity predicts reduction of non-suicidal self-injury in adolescents with major depressive disorder: An event related potential study

et al. 2022

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“… 27 Neuroimaging studies have reported significant anterior cingulate cortex activation and reduced medial prefrontal cortex connectivity in adolescents with NSSI compared to healthy controls, 28 , 29 these brain region changes are crucial for the performance of executive function. However, the results of executive functioning in adolescent with NSSI engagement are inconsistent, some studies indicating little evidence of executive functioning differences between adolescents with NSSI and healthy controls; 30 while others demonstrating significant executive function deficits in NSSI groups, 31 , 32 and adolescents who currently NSSI exhibiting poor decision-making skills compared to those with a previous history of NSSI. 33 …”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Perceived Stress, Impulsivity, Executive Dysfunction and Non-Suicidal Self-Injury Thoughts Among Chinese College Students: A Gender Difference Study

Zhou,

Zhang,

Guo

et al. 2024

PRBM

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Background The present study aimed to investigate the potential role of perceived stress, impulsivity trait, executive dysfunction in non-suicidal self-injury (NSSI) thoughts among college students, as well as the gender differences. Methods A sample of 890 university students completed self-report measures of NSSI thoughts in the past month, the level of perceived stress, impulsivity traits, and executive dysfunction. Results Compared to those with low level of perceived stress, participants with high level of perceived stress reported significant higher levels of impulsivity trait and executive dysfunction, and higher frequency of NSSI thoughts, and there were no gender differences. Male participants with NSSI thoughts, compared to males without NSSI thoughts, reported significant higher levels of perceived stress and executive dysfunction. Female participants with NSSI thoughts, compared to females without NSSI thoughts, reported significant higher levels of perceived stress, impulsivity trait, and executive dysfunction. Hierarchical regression analysis revealed only executive dysfunction was associated with NSSI thoughts in males, while only perceived stress was associated with NSSI thoughts in females. Conclusion This study revealed different influence factors for NSSI thoughts in male and female college students. NSSI thoughts in males were more likely associated with executive dysfunction while in females were due to recently perceived stress.

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“…Considering that suicidal behavior usually begins with self-injury, a common behavior among young patients with depression, investigating the suicidal risk factors in people having MDD with self-injury behavior is critical. Based on the assessment of various behavioral abnormalities, such as executive dysfunction in adolescents with depression and NSSI [ 11 ] and patients having bipolar disorder with suicidal ideation [ 12 ] as well as impaired decision-making in those with SA [ 13 ], several statistical and actuarial scales have been developed to aid clinicians to predict and manage suicide risk [ 14 – 16 ]. Studies investigating biomarkers and neural markers of suicide risk [ 17 ] have suggested neural connectivity as a response predictor for psychotherapy in individuals with NSSI [ 18 ] as well as biologically-informed approaches [ 19 ], including low serum cholesterol level, as potential suicide risk biomarkers in patients with MDD and suicidal behavior [ 2 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Distinct correlation network of clinical characteristics in suicide attempters having adolescent major depressive disorder with non-suicidal self-injury

Peng,

Wang,

Zuo

et al. 2024

Transl Psychiatry

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Suicidal behavior and non-suicidal self-injury (NSSI) are common in adolescent patients with major depressive disorder (MDD). Thus, delineating the unique characteristics of suicide attempters having adolescent MDD with NSSI is important for suicide prediction in the clinical setting. Here, we performed psychological and biochemical assessments of 130 youths having MDD with NSSI. Participants were divided into two groups according to the presence/absence of suicide attempts (SAs). Our results demonstrated that the age of suicide attempters is lower than that of non-attempters in participants having adolescent MDD with NSSI; suicide attempters had higher Barratt Impulsiveness Scale (BIS-11) impulsivity scores and lower serum CRP and cortisol levels than those having MDD with NSSI alone, suggesting levels of cortisol and CRP were inversely correlated with SAs in patients with adolescent MDD with NSSI. Furthermore, multivariate regression analysis revealed that NSSI frequency in the last month and CRP levels were suicidal ideation predictors in adolescent MDD with NSSI, which may indicate that the increased frequency of NSSI behavior is a potential risk factor for suicide. Additionally, we explored the correlation between psychological and blood biochemical indicators to distinguish suicide attempters among participants having adolescent MDD with NSSI and identified a unique correlation network that could serve as a marker for suicide attempters. Our research data further suggested a complex correlation between the psychological and behavioral indicators of impulsivity and anger. Therefore, our study findings may provide clues to identify good clinical warning signs for SA in patients with adolescent MDD with NSSI.

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Associations between executive function impairment and biochemical abnormalities in depressed adolescents with non-suicidal self-injury

Cited by 13 publications

References 60 publications

Prefrontal cortex neural activity predicts reduction of non-suicidal self-injury in adolescents with major depressive disorder: An event related potential study

Prefrontal cortex neural activity predicts reduction of non-suicidal self-injury in adolescents with major depressive disorder: An event related potential study

The Relationship Between Perceived Stress, Impulsivity, Executive Dysfunction and Non-Suicidal Self-Injury Thoughts Among Chinese College Students: A Gender Difference Study

Distinct correlation network of clinical characteristics in suicide attempters having adolescent major depressive disorder with non-suicidal self-injury

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