Associations between generic substitution and patients' attitudes, beliefs and experiences

Rathe, Jette Østergaard; Larsen, Pia Veldt; Andersen, Morten; Paulsen, Maja Skov; Jarbøl, Dorte Ejg; Thomsen, Janus Laust; Soendergaard, Jens

doi:10.1007/s00228-013-1539-z

Cited by 34 publications

(42 citation statements)

References 22 publications

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“…Com o aumento da oferta de medicamentos genéricos, pode ter havido maior variação na qualidade deles por causa da heterogeneidade do processo de produção, uma vez que a legislação permite um desvio da determinação quantitativa do fármaco em matérias-primas ou em formas farmacêuticas de 80 a 120% nos testes de biodisponibilidade 41 . Por outro lado, estudos têm demonstrado melhor aceitação dos genéri-cos por aqueles com experiência com esses medicamentos, mas aqueles que experimentaram mostraram boa percepção e aceitação dos medicamentos genéricos 7,42,43 .…”

Section: Discussionunclassified

“…As variáveis independentes estudadas foram sexo, idade (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59), 60 anos ou mais), escolaridade (0-4, 5-8 e 9 ou mais anos completos de estudo) e classe econômica baseada no Crité-rio de Classificação Econômica Brasileira vigente em cada ano (A são os mais ricos e E os mais pobres) 11,12 .…”

Section: Métodosunclassified

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Percepção, conhecimento e uso de medicamentos genéricos no Sul do Brasil: o que mudou entre 2002 e 2012?

et al. 2016

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Resumo: Este estudo compara a percepção, conhecimento e uso de medicamentos genéricos em adultos de Pelotas, Rio Grande do Sul, Brasil, por meio de dois estudos transversais de base populacional realizados em 2002 e 2012. Os desfechos estudados foram: (a) prevalência de utilização de medicamentos genéricos; (b) proporção de uso de medicamentos genéricos entre os demais medicamentos; (c) percepção dos usuários sobre preço e qualidade dos medicamentos genéricos; (d) conhecimento dos usuários sobre medicamentos genéricos; e (e) estratégias de aquisição de medicamentos. A prevalência de uso de medicamentos genéricos aumentou de 3,6% (IC95%: 3,0-4,3) para 26,1% (IC95%: 24,5-27,7) no período de dez anos. A percepção sobre preço e qualidade dos medicamentos genéricos se manteve estável, a identificação das características que diferenciam os medicamentos genéricos dos demais medicamentos melhorou (p < 0,001) e o erro de classificação de medicamento diminuiu (p < 0,001). Houve um aumento significativo na estratégia de aquisição de medicamentos pela substituição do medicamento prescrito pelo medicamento genérico. Entre 2002 e 2012, aumentou o conhecimento e uso de medicamentos genéricos, enquanto a percepção quanto ao menor preço e qualidade equivalente mantiveram-se elevadas.

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Percepção, conhecimento e uso de medicamentos genéricos no Sul do Brasil: o que mudou entre 2002 e 2012?

et al. 2016

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“…The percentages of patients who had experienced a generic substitution comprised 35.3%, 26%, and 32.6% for the antidepressant group, AED group, and other substitutable group, respectively. The study findings showed that previous experience of generic switches within the index Anatomical Therapeutic Chemical (ATC) code 66 and younger age group were significantly associated with the experience of generic substitution. Conversely, having more than five substitutions in other ATC codes and negative views about generic medicines were negatively associated with the experience of generic substitution.…”

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confidence: 92%

“…Thus, education and reassurance are important in promoting the use of generic medicines and to enhance patient acceptance. 65 Rathe et al 66 conducted a study in Southern Denmark to evaluate the association between generic switching or substitution and patients' beliefs, attitudes, and experiences. Their study focused on three groups of medicines, namely AEDs, antidepressants, and a third group which included some other substitutable medicines.…”

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confidence: 99%

“…However, there were no significant associations between generic substitution and medicine group, number of medicines the patients were taking, and their general belief about generic medicines. 66 Roman 67 conducted a study in the Netherlands to evaluate the attitudes of psychiatric patients (with psychosis/ schizophrenia) towards generic substitution of oral atypical antipsychotic agents. In a hypothetical pharmacy setting, 106 patients with psychosis/schizophrenia were confronted with generic substitution using two scenarios.…”

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Patient knowledge, perceptions, and acceptance of generic medicines: a comprehensive review of the current literature

Alrasheedy¹,

Hassali²,

Stewart³

et al. 2014

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Background: Generic medicines have the same quality, safety, and efficacy as their counterpart original brand medicines. Generic medicines provide the same therapeutic outcomes but at a much cheaper cost, so are promoted in many countries to contain pharmaceutical expenditure and sustain the health care system. Thus, the perspective of patients and medicine consumers as end users of these medicines is an important factor to enhance the use and utilization of generic medicines. The objective of this paper is to review patients' and consumers' knowledge, perceptions, acceptance, and views of generic medicines in the current literature. Methods: An extensive literature search was performed in several databases, namely Scopus, PubMed, ISI Web of Knowledge, Proquest, and the Wiley online library, to identify relevant studies published in the English literature for the period 1990-2013. Results: A total of 53 studies were included in the review, comprising 24 studies from Europe, ten from North America, six from Asia, five from Australia and New Zealand, five from the Middle East, one from Africa, one from Latin America, and one from the Caribbean region. A large body of literature has reported misconceptions and negative perceptions about generic medicines on the part of patients and medicine consumers. Moreover, although it is reported in almost all countries, the percentage of consumers who had such misconceptions varied from one country to another. However, in many countries, there was a meaningful percentage of patients who had negative perceptions and misconceptions about generic medicines. Moreover, such misconceptions and negative perceptions were reported as major obstacles to the use and acceptance of generic medicines among patients. Further, studies that focused on specific populations (eg, patients with epilepsy, psychosis, or renal disease) reported a more negative perception and more resistance to the use of generic medicines. The type of medical condition and its level of seriousness or severity, recommendations by health care professionals, price difference (ie, cost saving), previous experience of generic medicines, and knowledge/information about generic medicines were considered to be important factors that affect a patient's decision to use a generic medicine or a brand medicine. Conclusion:The results from this literature search show that patients and medicine consumers tend to prefer original brand medicines over generic medicines. Further, in many countries, there is still a considerable proportion of patients and consumers who lack adequate knowledge or have insufficient information about generic medicines. Thus, there is a need for educational interventions and activities to educate patients about generic medicines. It is also evident in the literature that health care professionals (physicians and pharmacists) play a key role in the promotion of generic medicines and in patients' acceptance of generic medicines and generic substitution. Hence, health care professionals need to play a more act...

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Patients' concern about their medicine after a generic switch: a combined cross‐sectional questionnaire and register study

Rathe

Søndergaard

Jarbøl

et al. 2014

Pharmacoepidemiology and Drug

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Associations between generic substitution and patients' attitudes, beliefs and experiences

Cited by 34 publications

References 22 publications

Percepção, conhecimento e uso de medicamentos genéricos no Sul do Brasil: o que mudou entre 2002 e 2012?

Percepção, conhecimento e uso de medicamentos genéricos no Sul do Brasil: o que mudou entre 2002 e 2012?

Patient knowledge, perceptions, and acceptance of generic medicines: a comprehensive review of the current literature

Patients' concern about their medicine after a generic switch: a combined cross‐sectional questionnaire and register study

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