Associations between Gestational Diabetes and Anxiety or Depression: A Systematic Review

Ouyang, Hong; Chen, Bin; Al-Mureish, Abdulrahman; Li, Ling; Wu, Na

doi:10.1155/2021/9959779

Cited by 89 publications

(49 citation statements)

References 55 publications

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“…Gestational diabetes mellitus (GDM) is the most common metabolic complication during pregnancy, affecting up to 25% of pregnancies [ 1 ]. Women with GDM have higher risks of developing hypertensive disorders during pregnancy, in particular, pre-eclampsia, pre-term birth, cesarean delivery, as well as mental health problems such as anxiety and depression [ 2 , 3 , 4 ]. Risks to the children include macrosomia (20–30%), small for gestational age (7–10%), shoulder dystocia, neonatal hypoglycemia, neonatal hyperbilirubinemia, respiratory distress syndrome and stillbirth [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Proteomics Studies in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

Sriboonvorakul

Boriboonhirunsarn

et al. 2022

JCM

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Gestational Diabetes Mellitus (GDM) is the most common metabolic complication during pregnancy and is associated with serious maternal and fetal complications such as pre-eclampsia and stillbirth. Further, women with GDM have approximately 10 times higher risk of diabetes later in life. Children born to mothers with GDM also face a higher risk of childhood obesity and diabetes later in life. Early prediction/diagnosis of GDM leads to early interventions such as diet and lifestyle, which could mitigate the maternal and fetal complications associated with GDM. However, no biomarkers identified to date have been proven to be effective in the prediction/diagnosis of GDM. Proteomic approaches based on mass spectrometry have been applied in various fields of biomedical research to identify novel biomarkers. Although a number of proteomic studies in GDM now exist, a lack of a comprehensive and up-to-date meta-analysis makes it difficult for researchers to interpret the data in the existing literature. Thus, we undertook a systematic review and meta-analysis on proteomic studies and GDM. We searched MEDLINE, EMBASE, Web of Science and Scopus from inception to January 2022. We searched Medline, Embase, CINHAL and the Cochrane Library, which were searched from inception to February 2021. We included cohort, case-control and observational studies reporting original data investigating the development of GDM compared to a control group. Two independent reviewers selected eligible studies for meta-analysis. Data collection and analyses were performed by two independent reviewers. The PROSPERO registration number is CRD42020185951. Of 120 articles retrieved, 24 studies met the eligibility criteria, comparing a total of 1779 pregnant women (904 GDM and 875 controls). A total of 262 GDM candidate biomarkers (CBs) were identified, with 49 CBs reported in at least two studies. We found 22 highly replicable CBs that were significantly different (nine CBs were upregulated and 12 CBs downregulated) between women with GDM and controls across various proteomic platforms, sample types, blood fractions and time of blood collection and continents. We performed further analyses on blood (plasma/serum) CBs in early pregnancy (first and/or early second trimester) and included studies with more than nine samples (nine studies in total). We found that 11 CBs were significantly upregulated, and 13 CBs significantly downregulated in women with GDM compared to controls. Subsequent pathway analysis using Database for Annotation, Visualization and Integrated Discovery (DAVID) bioinformatics resources found that these CBs were most strongly linked to pathways related to complement and coagulation cascades. Our findings provide important insights and form a strong foundation for future validation studies to establish reliable biomarkers for GDM.

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Section: Introductionmentioning

confidence: 99%

Proteomics Studies in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

Sriboonvorakul

Boriboonhirunsarn

et al. 2022

JCM

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“…More studies involving vulnerable populations are required to better understand how structural features of perinatal interventions impact the prevention of pregnancy issues such as GDM. Additionally, studies have identified stress and anxiety as potential risk factors for GDM [ 50 , 51 , 52 ]. The large majority of participants in the present study had a low household income and were therefore more likely to present high stress and anxiety levels related to economic precarity.…”

Section: Discussionmentioning

confidence: 99%

A Community Prenatal Intervention in Social Nutrition: Evaluating the Impact on Pregnancy and Birthweight Outcomes

et al. 2022

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This study aims to assess the associations between structural features of the Montreal Diet Dispensary’s social nutrition intervention and pregnancy (i.e., anemia, gestational diabetes mellitus (GDM), gestational weight gain (GWG), hypertension) and birthweight outcomes (i.e., small- or large-for-gestational-age) among pregnant women, most of them recent immigrants. The study consists of a secondary analysis of the digital client database of the Montreal Diet Dispensary (n = 2925). Logistic regressions were used to estimate the odds of pregnancy and birthweight outcomes, depending on structural features of the intervention. Pregnant women who attended a welcoming group session presented lower odds of GDM and anemia compared to those who did not attend. A longer duration of intervention was also associated with lower odds of GDM and anemia. Each additional appointment with a dietitian was associated with higher odds of excessive GWG and lower odds of insufficient GWG only among women with a pre-pregnancy BMI lower than 25 kg/m2. This study emphasizes the importance of providing nutritional services early in pregnancy to reduce the risk of GDM and anemia. It also stresses the importance of using appropriate nutritional guidelines to avoid increasing the risk of excessive GWG.

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“…In studies on murine prenatal stress, males’ placental OGT and O -GlcNAcylation levels were more impacted than females. With extra copies of OGT available, it was hypothesized that female offspring may have a greater capacity to rapidly respond to maternal stress 29 or, in the case of gestational diabetes, prolonged exposure to hyperglycemic stress 45–48 . In this context, we hypothesized that male placental OGT and O -GlcNAcylation levels might be more affected by stressors leading to induction of GDM.…”

Section: Discussionmentioning

confidence: 99%

O-GlcNAc transferase contributes to sex-specific placental deregulation in gestational diabetes

Cui

Cruz

Palatnik

et al. 2022

Preprint

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Fetal sex has been known to be associated with differential risks for adverse perinatal outcomes. Recently it has been highlighted as a risk factor for gestational diabetes (GDM), which carries short- and long-term cardiometabolic implications for the pregnant women and their offspring. Understanding the molecular mechanisms through which fetal sex can modulate placenta physiology can help identify novel molecular targets for future clinical applications. In this study, we investigated the nutrient-sensing O-GlcNAc pathway as a potential mediator of sex-driven placenta dysfunction due to the unique location of the O-GlcNAc transferase (OGT) enzyme on the X chromosome. Using banked placenta tissues, we demonstrated that placenta OGT is downregulated in women with GDM, especially when carrying a male offspring. We modeled our observation in vitro using male placenta trophoblast BeWo cells in which OGT was knocked down. A comprehensive transcriptomic profile via RNA sequencing demonstrated changes in hormonal, inflammatory and immunologic markers, toward GDM-like transcriptional signatures. Altogether, this study suggests that OGT deserves important consideration for sexual dimorphism observed in GDM and highlights the importance of O-GlcNAcylation in placenta endocrine physiology.

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Associations between Gestational Diabetes and Anxiety or Depression: A Systematic Review

Cited by 89 publications

References 55 publications

Proteomics Studies in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

Proteomics Studies in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

A Community Prenatal Intervention in Social Nutrition: Evaluating the Impact on Pregnancy and Birthweight Outcomes

O-GlcNAc transferase contributes to sex-specific placental deregulation in gestational diabetes

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