Associations between GLUT expression and SUV values derived from FDG-PET in different tumors—A systematic review and meta analysis

Abstract

Purpose Fluorodeoxyglucose-Positron-emission tomography (FDG-PET), quantified by standardized uptake values (SUV), is one of the most used functional imaging modality in clinical routine. It is widely acknowledged to be strongly associated with Glucose-transporter family (GLUT)-expression in tumors, which mediates the glucose uptake into cells. The present systematic review sought to elucidate the association between GLUT 1 and 3 expression with SUV values in various tumors. Methods MEDLINE library was screened for associations between FDG-PET parameters and GLUT correlation cancer up to October 2018. Results There were 53 studies comprising 2291 patients involving GLUT 1 expression and 11 studies comprising 405 patients of GLUT 3 expression. The pooled correlation coefficient for GLUT 1 was r = 0.46 (95% CI 0.40–0.52), for GLUT 3 was r = 0.35 (95%CI 0.24–0.46). Thereafter, subgroup analyses were performed. The highest correlation coefficient for GLUT 1 was found in pancreatic cancer r = 0.60 (95%CI 0.46–0.75), the lowest was identified in colorectal cancer with r = 0.21 (95% CI -0.57–0.09). Conclusion An overall only moderate association was found between GLUT 1 expression and SUV values derived from FDG-PET. The correlation coefficient with GLUT 3 was weaker. Presumably, the underlying mechanisms of glucose hypermetabolism in tumors are more complex and not solely depended on the GLUT expression.

Comprehensive gene expression analysis for exploring the association between glucose metabolism and differentiation of thyroid cancer

“…In terms of another prognostic marker in our results, glycolysis signature, it is notable that glucose metabolism profiles can be noninvasively estimated by FDG PET. GLUT score, calculated by GLUT1 and GLUT3, was reported as the major deterministic factor for the FDG uptake in various studies (10,15,21,22), while a recent study showed a moderate correlation between FDG uptake and GLUT regarding a complex mechanism of glucose metabolism (23). Furthermore, glycolysis activity is also associated with FDG uptake in vivo (22,24).…”

Correlation Between Glucose Metabolism Parameters Derived From FDG and Tumor TNM Stages and Metastasis-Associated Proteins in Colorectal Carcinoma Patients

“…Enhanced FDG uptake re ect the heterogeneity of glucose metabolism. The correlation between GLUT-1 and FDG uptake was found in multiple malignancies such as breast cancer [21], lung cancer [22], cervical cancer [23] pancreatic cancer [24] and colorectal cancer [12] et al However, Ran Hong's study show that the GLUT-1 expression was not associated with FDG uptake, the discrepancy between two studies may be caused by differences in FDG parameters, only one radio-parameter was included in Ran Hong's research [25]. There was few study regarded to the relationship between MACC1 and FDG uptake, the present study demonstrated a statistical correlation between MACC1 expression and TLG of CRC patients for the rst time.…”

“…The parameters of 18 F-FDG re ect the tracer uptake by tumor cells and provides objective data on tumor glucose metabolism. Recently, the correlation between radio-parameters derived from FDG-PET and tumor biomarkers has been extensively investigated, especially GLUT-1, high expression of GLUT-1 is identi ed as promote the FDG uptake in wide variety of solid tumors [12]. However, the role of MACC1 in contribute to FDG uptake needs further exploration.…”

L-Glucose: Another Path to Cancer Cells

“…Marom and colleagues reported that neither GLUT1 nor GLUT3 protein levels correlated with 2-FDG uptake in 73 patients with early-stage, non-small cell lung carcinoma [103]. In a recent review, Mayer and colleagues mentioned that GLUT expression and SUV derived from 2-FDG-PET were only moderately associated in various cancers [104]. These studies cast doubt that GLUTs are responsible for enhanced glucose uptake in cancerous cells, although involvement of non-canonical GLUTs such as GLUT12 could not be excluded [105].…”

“…In 1996, Matsuoka and colleagues published three consecutive papers about a novel d-glucose tracer [109][110][111]. By reacting NBD-chloride with 2-amino-2-deoxy- expression and SUV derived from 2-FDG-PET were only moderately associated in various cancers [104]. These studies cast doubt that GLUTs are responsible for enhanced glucose uptake in cancerous cells, although involvement of non-canonical GLUTs such as GLUT12 could not be excluded [105].…”