Associations between Handgrip Strength with Adverse Cardiometabolic Health among Representative Korean Adults

An, Keun-Ok; Kim, Jung-Hoon

doi:10.3390/ijerph17010269

Cited by 9 publications

(8 citation statements)

References 41 publications

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“…A Japanese study showed that changes in HDL-cholesterol were significantly and independently associated with changes in HGS in older people [ 32 ]. These results are similar to those obtained by other authors that in previous studies have demonstrated that low HDL-cholesterol levels are common in institutionalized or community-dwelling older adults with functional impairments [ 33 , 34 , 35 ]. Therefore, reduced HDL-cholesterol levels have been proposed as a general marker of “poor well-being” and reduced physical condition [ 36 ].…”

Section: Discussionsupporting

confidence: 92%

Health Risk, Functional Markers and Cognitive Status in Institutionalized Older Adults: A Longitudinal Study

Pedrero‐Chamizo

Albers

Palacios

et al. 2020

IJERPH

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A Follow-up of vitamin B12 and lipids status is essential in older people, being closely related to non-communicable diseases. Their relationships with cognitive and physical status are not clear. The aim was to analyze the evolution of vitamin B12 and related parameters, lipid and hematological profiles, and their relationships with cognitive and physical status among institutionalized elderly. Sixty residents, ranged from 62 to 99, were evaluated. Biomarkers (vitamin B12 and related parameters, lipid and hematological profiles), functional capacity (handgrip, arm and leg strength), and cognitive status (Mini-Mental State Examination) were evaluated four times at 4-month intervals. At the beginning of the study, 63% and 70% of the sample showed abnormal homocysteine and folate values, respectively. At the end of the year, abnormal homocysteine increased to 68%, abnormal folate values decreased to 50%. Throughout the year, serum folate showed a significant increase (14.9 vs. 16.3 nmol/L), (p < 0.05). Serum cobalamin (299 vs. 273 pmol/L). HDL-cholesterol (49.9 vs. 47.0 mg/dL) and triglyceride levels (102.4 vs. 123.2 mg/dL) showed a significant decrease and increase respectively in mean values (all p < 0.05). Serum cobalamin and HDL-cholesterol were the most important biomarkers associated with cognitive function (both p < 0.05). The most relevant biomarkers associated with poor physical strength depending on the body part analyzed were low concentrations of HDL-cholesterol, LDL-cholesterol, apolipoprotein A1, and albumin (all p < 0.05). The evolution of lipid biomarkers, their significance with cognitive values, and association with handgrip, point to the importance of the handgrip measurement, a very simple test, as an important health marker. Both serum albumin and physical strength are important health markers in older people.

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Section: Discussionsupporting

confidence: 92%

Health Risk, Functional Markers and Cognitive Status in Institutionalized Older Adults: A Longitudinal Study

Pedrero‐Chamizo

Albers

Palacios

et al. 2020

IJERPH

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“…Weaker handgrip strength is a measure of sarcopenia which reflects poor intrinsic capacity and contributes to lower functional ability of older adults 47 , 48 . In addition, a growing body of literature suggests a significant association between handgrip strength and cardiometabolic disease risk 49 which further increases the rate of cognitive decline and depending upon the environment, can negatively impact functional ability 50 . Focusing on cognitive capacity, findings from this cross-sectional study show a consistent and positive association between handgrip strength and cognition in six middle income countries.…”

Section: Discussionmentioning

confidence: 99%

Socioeconomic differences in handgrip strength and its association with measures of intrinsic capacity among older adults in six middle-income countries

Arokiasamy

Selvamani

Jotheeswaran

et al. 2021

Sci Rep

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Handgrip strength, a measure of muscular strength is a powerful predictor of declines in intrinsic capacity, functional abilities, the onset of morbidity and mortality among older adults. This study documents socioeconomic (SES) differences in handgrip strength among older adults aged 50 years and over in six middle-income countries and investigates the association of handgrip strength with measures of intrinsic capacity—a composite of all the physical and mental capacities of an individual. Secondary data analysis of cross-sectional population-based data from six countries from the WHO’s Study on global AGEing and adult health (SAGE) Wave 1 were conducted. Three-level linear hierarchical models examine the association of demographic, socioeconomic status and multimorbidity variables with handgrip strength. Regression-based Relative Index of Inequality (RII) examines socioeconomic inequalities in handgrip strength; and multilevel linear and logistic hierarchical regression models document the association between handgrip strength and five domains of intrinsic capacity: locomotion, psychological, cognitive capacity, vitality and sensory. Wealth quintiles are positively associated with handgrip strength among men across all countries except South Africa while the differences by education were notable for China and India. Work and nutritional status are positively associated with handgrip strength. Our findings provide new evidence of robust association between handgrip strength and other measures of intrinsic capacity and confirms that handgrip strength is a single most important measure of capacity among older persons.

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“…Low HDL cholesterol was defined as <40 mg/dL for men and <50 mg/dL for women. Finally, we also computed the total number of adverse cardiometabolic risk factors and defined ‘high risk’ as ≥3 adverse or ≥4 adverse cardiometabolic risk factors [ 27 , 28 ].…”

Section: Methodsmentioning

confidence: 99%

Isotemporal Substitution Analysis of Accelerometer-Derived Sedentary Behavior and Physical Activity on Cardiometabolic Health in Korean Adults: A Population-Based Cross-Sectional Study

Kim

2021

IJERPH

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Reducing sedentary behavior and increasing physical activity may be important for maintaining good cardiometabolic health. However, many studies have focused on the independent effect of sedentary behavior and physical activity, but it is unclear whether replacing time spent in sedentary behavior with physical activity is beneficial for cardiometabolic health. Therefore, this population-based cross-sectional study aimed to investigate the effect of behavioral transformations between sedentary behavior and level of physical activity on cardiometabolic health in Korean adults using data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2014–2017. The study participants included 2197 adults from the KNHANES. In the partition model, moderate-to-vigorous physical activity (MVPA) was significantly associated with adverse cardiometabolic health, adjusted for potential confounding factors. The odds ratio for adverse cardiometabolic health significantly decreased with the replacement of sedentary behavior and light intensity activity with MVPA in the isotemporal substitution model (p < 0.05). In the models stratified by sex, we observed significant associations between handgrip strength and cardiometabolic health in women (p < 0.001), but not in men. Thus, our findings suggest that replacing sedentary behavior with MVPA may contribute to improved cardiometabolic health.

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Associations between Handgrip Strength with Adverse Cardiometabolic Health among Representative Korean Adults

Cited by 9 publications

References 41 publications

Health Risk, Functional Markers and Cognitive Status in Institutionalized Older Adults: A Longitudinal Study

Health Risk, Functional Markers and Cognitive Status in Institutionalized Older Adults: A Longitudinal Study

Socioeconomic differences in handgrip strength and its association with measures of intrinsic capacity among older adults in six middle-income countries

Isotemporal Substitution Analysis of Accelerometer-Derived Sedentary Behavior and Physical Activity on Cardiometabolic Health in Korean Adults: A Population-Based Cross-Sectional Study

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