Associations Between hOGG1 Ser326Cys Polymorphism and Increased Body Mass Index and Fasting Glucose Level in the Japanese General Population

Hara, Megumi; Nakamura, Kazuyo; Nanri, Hinako; Nishida, Yuichiro; Hishida, Asahi; Kawai, Shinya; Hamajima, Nobuyuki; Kita, Yoshikuni; Suzuki, Sadao; Mantjoro, Eva M.; Ohnaka, Keizo; Uemura, Hirokazu; Matsui, Daisuke; Oze, Isao; Mikami, Haruo; Kubo, Michiaki; Tanaka, Hideo

doi:10.2188/jea.je20140002

Cited by 9 publications

(5 citation statements)

References 33 publications

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“…In human populations, a relatively common OGG1 polymorphism, Ser326Cys, is associated with reduced glycosylase activity, and has been shown to be correlated with increased body mass index and elevated total cholesterol and fasting blood glucose in Japanese individuals homozygous for the mutation [209]. Similarly, in a Mexican cohort, the Ser326Cys polymorphism was independently correlated with increased incidence of type-2 diabetes [119].…”

Section: Metabolic Diseasementioning

confidence: 99%

Mitochondrial DNA Integrity: Role in Health and Disease

Sharma

Sampath

2019

Cells

179

131

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As the primary cellular location for respiration and energy production, mitochondria serve in a critical capacity to the cell. Yet, by virtue of this very function of respiration, mitochondria are subject to constant oxidative stress that can damage one of the unique features of this organelle, its distinct genome. Damage to mitochondrial DNA (mtDNA) and loss of mitochondrial genome integrity is increasingly understood to play a role in the development of both severe early-onset maladies and chronic age-related diseases. In this article, we review the processes by which mtDNA integrity is maintained, with an emphasis on the repair of oxidative DNA lesions, and the cellular consequences of diminished mitochondrial genome stability.

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Section: Metabolic Diseasementioning

confidence: 99%

Mitochondrial DNA Integrity: Role in Health and Disease

Sharma

Sampath

2019

Cells

179

131

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“…In the Cys/Cys genotyped individuals, body mass index was found to be higher [25]. In another study on the Japanese population, patients carrying the Cys/Cys or the Cys/Ser genotypes, HOMA-beta, an indicator of beta cell function, was decreased with improved glucose tolerance, however, among patients with the Ser/Ser genotype, it was elevated in individuals with glucose intolerance but decreased in ones with diabetes [26].…”

Section: Discussionmentioning

confidence: 90%

Investigation of DNA repair genes XPD and hOGG1 in type 2 Diabetes mellitus

Yigitbasi¹,

Yurdum²,

Yılmaz³

et al. 2017

Med-Science

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Increased oxidative stress in type 2 diabetes cause to the accumulation of DNA damage and results diabetic complications. Xeroderma pigmentosum complementation group D (XPD) and human oxoguanine glycosylase 1 (hOGG1) are genes involved in the repair of oxidative DNA damage. In this study, we aimed to evaluate association between XPD Lys751Gln and hOGG1 Ser326Cys polymorphisms with type 2 diabetes mellitus (T2DM) in the Turkish population. Seventy-one T2DM patients and 54 healthy individuals were incorporated into this study. DNA was extracted from whole blood. The Polymerase Chain Reaction (PCR)-Restriction Fragment Length Polymorphism (RFLP) techniques were used. There was statistically significant difference between patient and control groups in the genotype distribution of XPD Lys751Gln polymorphism (p˂0.05). While the Lys/Lys genotype was found significantly higher in control group, the Lys/Gln was higher in patients. (p˂0.05). There was no significant difference between groups in the genotype distribution of hOGG1 Ser326Cys polymorphism. Despite the small number of subjects included in the study, it could be interpreted that the Lys/Gln genotype of XPD Lys751Gln polymorphism may be contributing to the development of diabetes.

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“…A previous study (J-MICC study) reported on the heterogeneity between the study areas. Hara et al found that the study area had a significant impact on the prevalence of obesity [ 41 ]. It is therefore important to consider the heterogeneity between the study areas.…”

Section: Methodsmentioning

confidence: 99%

Associations between Dietary Patterns, ADRβ2 Gln27Glu and ADRβ3 Trp64Arg with Regard to Serum Triglyceride Levels: J-MICC Study

et al. 2016

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Interactions between dietary patterns and 2 β-adrenergic receptor (ADRβ) gene polymorphisms (ADRβ2 Gln27Glu and ADRβ3 Trp64Arg) were examined with regard to the effects on serum triglyceride levels. The cross-sectional study comprised 1720 men and women (aged 35–69 years) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Genotyping was conducted using a multiplex polymerase chain reaction-based invader assay. We used 46 items from a validated short food frequency questionnaire and examined major dietary patterns by factor analysis. We identified four dietary patterns: healthy, Western, seafood and bread patterns. There was no significant association between any dietary pattern and serum triglyceride levels. After a separate genotype-based analysis, significant interactions between ADRβ3 Trp64Arg genotype and the bread pattern (p for interaction = 0.01) were associated with serum triglyceride levels; specifically, after adjusting for confounding factors, Arg allele carriers with the bread pattern had lower serum triglycerides (p for trend = 0.01). However, the Trp/Trp homozygous subjects with the bread pattern showed no association with serum triglycerides (p for trend = 0.55). Interactions between other dietary patterns and ADRβ polymorphisms were not significant for serum triglyceride levels. Our findings suggest that ADRβ3 polymorphism modifies the effects of the bread pattern on triglyceride levels.

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Associations Between hOGG1 Ser326Cys Polymorphism and Increased Body Mass Index and Fasting Glucose Level in the Japanese General Population

Cited by 9 publications

References 33 publications

Mitochondrial DNA Integrity: Role in Health and Disease

Mitochondrial DNA Integrity: Role in Health and Disease

Investigation of DNA repair genes XPD and hOGG1 in type 2 Diabetes mellitus

Associations between Dietary Patterns, ADRβ2 Gln27Glu and ADRβ3 Trp64Arg with Regard to Serum Triglyceride Levels: J-MICC Study

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