Associations between Helicobacter pylori with nonalcoholic fatty liver disease and other metabolic conditions in Guatemala

Abstract

Background Previous studies have suggested an association between Helicobacter pylori (H pylori) and nonalcoholic fatty liver disease (NAFLD). The aim of the current study was to examine the association in Guatemala, a region with elevated prevalences of both H pylori and NAFLD. Associations between H pylori and other metabolic conditions were also examined, as were associations between H hepaticus and H bilis and the metabolic conditions. Materials & Methods The analysis included 424 participants from a cross‐sectional study in Guatemala. H pylori seropositivity was defined as positivity for ≥ 4 antigens. Seropositivities for H bilis and H hepaticus were defined as positivity for ≥ 2 antigens. NAFLD was estimated using the Fatty Liver Index and the Hepatic Steatosis Index. Other conditions examined were obesity, central obesity, hypercholesterolemia, low HDL, diabetes and metabolic syndrome (MetSyn). Prevalence odds ratios (POR) and 95% confidence intervals (CIs) were estimated. Results No overall associations between H pylori,H hepaticus, or H bilis and NAFLD or related metabolic conditions were found. Seropositivity for H pylori antigens CagA and VacA and H hepaticus antigen HH0713 was each significantly associated with NAFLD, however. In addition, associations were observed between the H pylori antigens HyuA, HP1564, and UreA and specified metabolic conditions. Conclusions While no overall associations between H pylori or Helicobacter species with NAFLD or related conditions were observed, some selected Helicobacter spp. antigens were associated with NAFLD. Further research is warranted to examine whether H. species are associated with any metabolic condition.

The association between Helicobacter pylori with nonalcoholic fatty liver disease assessed by controlled attenuation parameter and other metabolic factors

“…Due to its cost-effectiveness and non-invasiveness, the serology test is a common method used in the health screening center which is conducted as routine blood sampling. In addition, as various Hp antigens are associated differently with metabolic conditions, it would be better to verify multiple Hp antigen using multiplex serology [ 44 ], however, it was unavailable in this study. Also, we did not have information of Hp eradication history.…”

The Effects of Helicobacter Pylori Eradication on Liver Function and Metabolic Profile in Non-diabetic Non-alcoholic Steatohepatitis: A 5-year Randomized Clinical Trial

“…19 Thus, the variation in the presence of HP virulence is proposed to affect the severity of NASH. 14 The decrement of FBS was more significant in HP eradicated participants than the controls in this investigation. This outcome is in parallel with the previous studies, which showed glycemic improvement after HP eradication in participants with diabetes mellitus type 2.…”

“…13 On the other hand, some studies showed no association between HP and NASH. 14,15 The discrepancy seen in the current pieces of evidence may stem from several reasons. First, serum aminotransferase levels fluctuate in the course of NASH, thus, measuring these markers at a single time point might not reliably predict the inflammatory status of the disease.…”

Is Helicobacter pylori infection the risk factor of metabolic associated fatty liver disease：A cross-sectional study

“…Another cross-sectional study of 2051 Chinese asymptomatic adults found no relationship between H. pylori infection and NAFLD (31). Other studies based on Korean (32,33), American (34) and Guatemalan (35) population also showed that H. pylori infection was not associated with NAFLD.…”