Associations between intrauterine exposure to polychlorinated biphenyls on neonatal ano-genital distance

Sheinberg, Revital; Siegel, Eva Laura; Keidar, Ran; Mandel, Dror; Lubetzky, Ronit; Kohn, Elkana; Livneh, Ayelet; Tovbin, Josef; Betser, Moshe; Moskovich, Miki; Marom, Ronella; Ovental, Amit; Daniel, Sharon; Factor-Litvak, Pam; Berkovitch, Matitiahu; Levy, Amalia

doi:10.1016/j.reprotox.2020.06.005

Cited by 12 publications

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“…We used data collected from a birth cohort recruited at Shamir Medical Center (Assaf Harofe) and “Dana Dwek” Children’s Hospital, Tel Aviv Medical Center. Complete details of this birth cohort have been presented elsewhere ( Sheinberg et al, 2020 ; Berlin et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

Maternal Exposure to Polychlorinated Biphenyls and Asthma, Allergic Rhinitis and Atopic Dermatitis in the Offspring: The Environmental Health Fund Birth Cohort

et al. 2022

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Background: Polychlorinated biphenyls (PCBs) are persistent organic pollutants banned for use worldwide. Due to their biodegradation resistance, they accumulate along the food chain and in the environment. Maternal exposure to PCBs may affect the fetus and the infant. PCBs are immunotoxic and may damage the developing immune system. PCBs are associated with elevated IgE antibodies in cord blood and are considered to be predictive of atopic reactions. Several studies on the association between prenatal exposure to PCBs and atopic reactions were previously published, albeit with conflicting results.Objectives: To examine the association between maternal PCBs levels and atopic reactions in their offspring.Methods: During the years 2013–2015, a prospective birth cohort was recruited at the delivery rooms of Shamir Medical Center (Assaf Harofeh) and “Dana Dwek” Children’s Hospital. Four PCBs congeners were investigated: PCBs 118, 138, 153, and 180. In 2019, when children reached the age of 4–6 years, mothers were interviewed using the ISAAC questionnaire to assess symptoms of atopic reactions, including asthma, allergic rhinitis, and atopic dermatitis.Results: One hundred and fifty mother-child dyads were analyzed. No significant differences were found in the median serum PCBs concentrations of each studied congener or total PCBs for asthma, allergic rhinitis, atopic dermatitis diagnosis, or parent-reported symptoms. No association was found between exposure to total PCBs and the risk for asthma symptoms or diagnosis, adjusted to maternal age and family member with atopic condition: aOR = 0.94, 95%CI: (0.88; 0.99). No association was observed between each studied PCB congener and asthma symptoms or diagnosis. The same results were found also for other studied outcomes—allergic rhinitis and atopic dermatitis.Conclusion: Our study joins a series of previous studies that attempt to shed light on environmental exposures in utero as influencing factors for atopic conditions in children. Our results reflect the complexity of the pathophysiology of these phenomena. No relationship between maternal serum PCBs levels was demonstrated for asthma, allergic rhinitis, or atopic dermatitis. However, additional multi-participant studies, with longer, spanning into later pediatric age follow up are needed.

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Section: Methodsmentioning

confidence: 99%

Maternal Exposure to Polychlorinated Biphenyls and Asthma, Allergic Rhinitis and Atopic Dermatitis in the Offspring: The Environmental Health Fund Birth Cohort

et al. 2022

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“…Due to financial limitations, we measured concentrations of 4 PCBs from maternal blood of 183 mothers who gave birth at Shamir Medical Center (Assaf Harofeh). On average, included and excluded dyads were similar in terms of potential confounders such as birth weight, length of gestation, and maternal age ( 49 ).…”

Section: Methodsmentioning

confidence: 99%

Maternal and Newborn Thyroid Hormone, and the Association With Polychlorinated Biphenyls (PCBs) Burden: The EHF (Environmental Health Fund) Birth Cohort

et al. 2021

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Background: Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants found in human tissues. PCBs can be transferred through the placenta and may disrupt the maternal thyroid homeostasis, and affect fetal thyroid hormone production. Several studies have shown that intrauterine exposure to PCBs might be associated with abnormal levels of thyroid hormones in mothers and their offspring.Objectives: To examine the associations between environmental exposure to PCBs and thyroid hormone levels in mothers and newborns.Methods: The EHF-Assaf-Harofeh-Ichilov cohort includes 263 mothers-newborns dyads. A total of 157 mother-newborn dyads had both PCBs and thyroid function measures. Regression models were used to estimate associations between maternal PCB exposure and maternal and newborn thyroid function, controlling for possible confounders.Results: Four PCBs congeners were analyzed: PCBs 118, 138, 153, and 180. ∑PCBs median (IQR) level was 14.65 (2.83–68.14) ng/g lipids. The median maternal thyroid-stimulating hormone (TSH) level was 2.66 (0.70–8.23) μIU/ml, the median maternal free thyroxine (FT4) level was 12.44 (11.27–13.53) μg/dL, the median maternal thyroid peroxidase antibodies (TPO Ab) level was 9.6 (7.36–12.51) IU/mL. Newborns' median total thyroxine (T4) level was 14.8 (7.6–24.9) μg/dL. No association was found between exposure to different congeners or to ∑PCBs and maternal TSH, FT4, thyroglobulin autoantibodies (Tg Ab), TPO Ab and newborn total T4 levels. In multivariable analysis a 1% change in ∑PCBs level was significantly associated with a 0.57% change in maternal TSH levels in women with body mass index (BMI) < 19. The same association was observed for each of the studied PCB congeners. Maternal TPO Ab levels statistically significantly increased by 0.53 and 0.46% for 1% increase in PCB 118 and 153 congeners, respectively. In women with BMI > 25, the association between the PCBs levels and maternal TSH levels was in the opposite direction. No association was found in women with normal BMI (19–24.9).Conclusions: Background exposure to environmentally relevant concentrations of some PCBs can alter thyroid hormone homeostasis in pregnant women and might be associated with abnormal TSH levels and TPO-Ab in women with low BMI. However, these findings require further investigation.

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“…Nuestros hallazgos sugieren una asociación entre la exposición a PFOS durante la gestación y efectos antiandrogénicos en el feto en desarrollo, que se ven reflejadas en ratones prepuberes y adultos. Aunado a esto, una DAG más corta en humanos adultos se asocia con una mala calidad del semen y con infertilidad [70] lo que podría asociarse con las alteraciones en la calidad espermática y la posible subfertilidad que se muestran en este estudio.…”

Section: Discussionunclassified

“…Estudios recientes utilizan la DAG para estimar el efecto de las exposiciones a ftalato en el útero en humanos. Se ha observado una asociación negativa entre el índice anogenital y los niveles de diferentes contaminantes ambientales [70]. Se ha observado un vínculo entre la DAG y otros efectos sobre la salud reproductiva en los hombres: una DAG más corta en los hombres adultos se asocia con una mala calidad del semen y con infertilidad.…”

Section: Distancia Anogenital (Dag) E íNdice Gonadosomáticounclassified

“…Hasta la pubertad, el crecimiento gonadal y somático muestran un ritmo similar (crecimiento alométrico), es decir, el índice gonadosomático (IGS, gónada peso expresado como tanto por ciento del peso corporal total) es normalmente pequeño y constante. En la pubertad, comienza una fase de crecimiento superalométrico de la gónada, las gónadas crecen más rápido que otros órganos / el resto del cuerpo y por lo tanto aumenta el IGS [69,70].…”

Section: Distancia Anogenital (Dag) E íNdice Gonadosomáticounclassified

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Exposición a sulfonato de perfluorooctano (PFOS) durante el desarrollo gonadal temprano y sus efectos en la diferenciación testicular en ratones adultos CD-1

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Associations between intrauterine exposure to polychlorinated biphenyls on neonatal ano-genital distance

Cited by 12 publications

References 66 publications

Maternal Exposure to Polychlorinated Biphenyls and Asthma, Allergic Rhinitis and Atopic Dermatitis in the Offspring: The Environmental Health Fund Birth Cohort

Maternal Exposure to Polychlorinated Biphenyls and Asthma, Allergic Rhinitis and Atopic Dermatitis in the Offspring: The Environmental Health Fund Birth Cohort

Maternal and Newborn Thyroid Hormone, and the Association With Polychlorinated Biphenyls (PCBs) Burden: The EHF (Environmental Health Fund) Birth Cohort

Exposición a sulfonato de perfluorooctano (PFOS) durante el desarrollo gonadal temprano y sus efectos en la diferenciación testicular en ratones adultos CD-1

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