Associations between maternal physical activity in early and late pregnancy and offspring birth size: remote federated individual level meta‐analysis from eight cohort studies

Pastorino, Silvia; Bishop, Tom; Crozier, Sarah; Granström, Charlotta; Kordas, Katarzyna; Küpers, Leanne K.; O’Brien, Eileen C.; Polańska, Kinga; Sauder, Katherine A.; Zafarmand, Mohammad Hadi; Wilson, Rebecca; Agyemang, Charles; Burton, Paul R.; Cooper, Cyrus; Corpeleijn, Eva; Dabelea, Dana; Hanke, Wojciech; Inskip, Hazel; Olsen, Sjúrður F.; Vrijkotte, Tanja G. M.; Brage, Sören; Kennedy, Aileen; O'Gorman, Donal J.; Scherer, Paul; Wijndaele, Katrien; Wareham, Nick; Desoyé, Gernot; Ong, Kenneth

doi:10.1111/1471-0528.15476

Cited by 56 publications

(53 citation statements)

References 58 publications

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“…Wu et al 45 used two clinical data sets to develop and test the distributed logistic regression approach. Pastorino et al 46 used distributed regression to examine the association between maternal physical activity and the birth size of the infant using data from eight databases in Europe and the United States. Using the association between antibiotic treatment early in life and the body mass index z score later in life among children in 34 electronic healthcare databases in the United States, Toh et al 47 conducted a proof-of-concept study on how distributed linear regression can be used to examine the benefits and risks of medical products.…”

Section: Distributed Regression Using Summary-level Intermediate Statmentioning

confidence: 99%

Analytic and Data Sharing Options in Real‐World Multidatabase Studies of Comparative Effectiveness and Safety of Medical Products

Toh

2020

Clin Pharma and Therapeutics

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A wide range of analytic and data sharing options are available in nonexperimental multidatabase studies designed to assess the real‐world benefits and risks of medical products. Researchers often consider six scientific domains when choosing among these options—study design, exposure type, outcome type, covariate summarization technique, covariate adjustment method, and data sharing approach. This article reviews available analytic and data sharing options and discusses key scientific and practical considerations when choosing among these options in multidatabase studies of comparative effectiveness and safety of medical products. The scientific considerations must be balanced against what the data‐contributing sites are able or willing to share. While pooling of person‐level data sets remains the most familiar and analytically flexible approach, newer analytic and data sharing approaches that share less granular summary‐level information may be equally valid and preferred in some multidatabase studies, especially when sharing of person‐level data is challenging or infeasible.

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Section: Distributed Regression Using Summary-level Intermediate Statmentioning

confidence: 99%

Analytic and Data Sharing Options in Real‐World Multidatabase Studies of Comparative Effectiveness and Safety of Medical Products

Toh

2020

Clin Pharma and Therapeutics

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“…Mechanisms of action have been minimally investigated, but are expected to include favourable changes in adiposity, insulin sensitivity, blood pressure, blood lipid and lipoprotein concentrations [7,8]. Children born to active mothers may also benefit from reduced risk of prematurity [9,10], reduced risk of being small-or large-for gestational age [10,11], and a lower fat mass at birth [12].…”

Section: Introductionmentioning

confidence: 99%

Associations of Pregnancy Physical Activity with Maternal Cardiometabolic Health, Neonatal Delivery Outcomes and Body Composition in a Biethnic Cohort of 7305 Mother–Child Pairs: The Born in Bradford Study

et al. 2019

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Objective Physical activity is advocated for a range of benefits to the uncomplicated pregnancy. We investigated associations of mid-pregnancy physical activity with maternal and neonatal health in white British and Pakistani-origin women from a deprived urban setting. Methods The study was performed in 6921 pregnant women (53% Pakistani-origin) who contributed data for 7305 singleton births. At 26-28 weeks gestation, women were grouped into four activity levels (inactive/somewhat active/moderately active/ active) based on their self-reported physical activity. Linear regression with robust standard errors was used to calculate adjusted mean differences in health markers between the four groups of physical activity (reference group: inactive). Results Three-quarters (74%) of Pakistani-origin women and 39% of white British women were inactive. Trend-tests revealed that more active white British women tended to be less adipose, had lower fasting and postload glucose levels, lower triglyceride concentrations, and their babies were less adipose (smaller triceps and subscapular skinfolds) than less active white British women. Somewhat active Pakistani-origin women exhibited lower triglyceride concentrations and systolic blood pressure, higher high-density lipoprotein cholesterol levels, and their babies were less adipose (smaller mid-upper arm and abdominal circumferences; lower cord-blood leptin concentration) compared to inactive Pakistani-origin women. No associations were observed for gestational age or birth weight. Conclusions Physical activity performed mid-pregnancy was beneficially associated with maternal cardiometabolic health and neonatal adiposity, without influencing gestational age or birth weight. Associations were dose-dependent in white British women, and even a small amount of mid-pregnancy physical activity appeared to benefit some health markers in Pakistani-origin women.

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“…There is mounting evidence for the specificity of maternal PA during the third trimester and its impact on offspring weight and body composition. Individual meta‐analyses of eight cohort studies recently showed reduced risk of macrosomia and large‐for‐gestational‐age birth associated with moderate to vigorous PA and vigorous PA late in pregnancy but not with early pregnancy PA . Furthermore, these results were not mediated by maternal gestational diabetes and persisted after adjustment of maternal BMI suggesting that PA late in pregnancy may have a direct effect on birth size.…”

Section: Discussionmentioning

confidence: 99%

“…Pregnancy PA has not been associated with delivery timing; however, there are consistent results showing that maternal PA is associated with reduced risk of large-for-gestational-age birth, without increasing risk of small-for-gestational-age birth (3,4). Furthermore, recent meta-analyses of eight cohort studies indicated that PA in late, but not early, pregnancy was inversely associated with large-for-gestational-age birth (5). Results also showed stronger associations for higher intensity PA, indicating that both timing and intensity of maternal PA may be important for offspring health outcomes.…”

Section: Introductionmentioning

confidence: 95%

Relations among maternal physical activity during pregnancy and child body composition

Mudd

Scheurer

Pruett

et al. 2019

Obesity Science & Practice

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Summary Objective Physical activity (PA) during pregnancy is associated with lower neonatal fat mass, but associations with child body composition are mixed. The purpose of this study was to examine associations between trimester‐specific pregnancy PA and child body composition at 4 years. Methods Participants of the Minnesota Infant Nutrition, Neurodevelopment, and Obesity Study were asked to recall participation in any moderate or vigorous PA in the first (T1), second (T2) and third (T3) trimesters at about 5 years postpartum. Child fat mass and fat‐free mass were measured via air displacement plethysmography at 2 weeks, 3 months and 4 years of age. Multivariate linear regression was used for analyses. Results Of 51 possible participants, 37 recalled pregnancy PA. Any vigorous PA in T3 was associated with lower child fat mass at 4 years (adj β = −1.077, p < 0.05). Conclusion Late pregnancy PA may have lasting benefits for child body composition. Replication of these findings is needed in a larger sample with prospective measures.

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Associations between maternal physical activity in early and late pregnancy and offspring birth size: remote federated individual level meta‐analysis from eight cohort studies

Abstract: In an individual participant meta-analysis, late pregnancy moderate to vigorous physical activity modestly reduced birth size outcomes.

Cited by 56 publications

References 58 publications

Analytic and Data Sharing Options in Real‐World Multidatabase Studies of Comparative Effectiveness and Safety of Medical Products

Analytic and Data Sharing Options in Real‐World Multidatabase Studies of Comparative Effectiveness and Safety of Medical Products

Associations of Pregnancy Physical Activity with Maternal Cardiometabolic Health, Neonatal Delivery Outcomes and Body Composition in a Biethnic Cohort of 7305 Mother–Child Pairs: The Born in Bradford Study

Relations among maternal physical activity during pregnancy and child body composition

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