Associations between micronutrient intakes and gut microbiota in a group of adults with cystic fibrosis

Li, Li; Krause, Lutz; Somerset, Shawn

doi:10.1016/j.clnu.2016.06.029

Cited by 56 publications

(37 citation statements)

References 51 publications

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“…If retinal parainflammation develops into a chronic retinal malfunction, and constitutes a shift in the normal homeostasis or “balance” to adapt to the new physiological or metabolic conditions of AMD (as occurs in many other chronic inflammatory disease states), the disruption in the interrelationships between nutrition, the microbiome, and host metabolism may be key elements in the disruption of normal homeostasis. The gut microbiome composition may vary according to macro/micronutrient dietary habits, as shown in several studies . The redox state also strongly modulates the gut microbiota .…”

Section: Zinc and The Microbiomementioning

confidence: 97%

Zinc Nutrition and Inflammation in the Aging Retina

Gilbert

Pető²,

Lengyel³

et al. 2019

Molecular Nutrition Food Res

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Zinc is an essential nutrient for human health. It plays key roles in maintaining protein structure and stability, serves as catalytic factor for many enzymes, and regulates diverse fundamental cellular processes. Zinc is important in affecting signal transduction and, in particular, in the development and integrity of the immune system, where it affects both innate and adaptive immune responses. The eye, especially the retina‐choroid complex, has an unusually high concentration of zinc compared to other tissues. The highest amount of zinc is concentrated in the retinal pigment epithelium (RPE) (RPE‐choroid, 292 ± 98.5 µg g−1 dry tissue), followed by the retina (123±62.2 µg g−1 dry tissue). The interplay between zinc and inflammation has been explored in other parts of the body but, so far, has not been extensively researched in the eye. Several lines of evidence suggest that ocular zinc concentration decreases with age, especially in the context of age‐related disease. Thus, a hypothesis that retinal function could be modulated by zinc nutrition is proposed, and subsequently trialled clinically. In this review, the distribution and the potential role of zinc in the retina‐choroid complex is outlined, especially in relation to inflammation and immunity, and the clinical studies to date are summarized.

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Section: Zinc and The Microbiomementioning

confidence: 97%

Zinc Nutrition and Inflammation in the Aging Retina

Gilbert

Pető²,

Lengyel³

et al. 2019

Molecular Nutrition Food Res

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“…Intakes of micronutrients such as vitamin C, vitamin E, niacin, beta-carotene, and riboflavin negatively correlated with the intestinal abundance of Bacteroides while intakes of betacarotene and vitamin E correlated positively with Firmicutes in the setting of cystic fibrosis. Mechanism by which antioxidant vitamins influence gut microbiota still yet not being clarified (Li et al, 2017). Intakes of some flavonoids may be associated with gut microbiota variations as demonstrated by a clinical study of adult with cystic fibrosis (Li and Somerset, 2018).…”

Section: Supplementing Micronutrients To Regulate Gut Microbiotamentioning

confidence: 99%

The Cross-Talk Between Gut Microbiota and Lungs in Common Lung Diseases

et al. 2020

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Emerging findings indicate there is a vital cross-talk between gut microbiota and the lungs, which is known as gut-lung axis. The gut disturbances in lung diseases including allergy, asthma, chronic obstructive pulmonary disease, cystic fibrosis and lung cancer were observed by extensive studies. Investigating how gut microbiota impact other distant organs is of great interest in recent years. Although it has not been fully understood whether the disturbance is the cause or effect of lung diseases, alterations in the gut microbial species and metabolites have been linked to changes in immune responses and inflammation as well as the disease development in the lungs. In this article, we systemically review the role and mechanisms underlying the changes in the constituent of gut microbiota and metabolites in lung diseases. In particular, the roles of gut-lung axis in mediating immune responses and reshaping inflammation are highlighted. Furthermore, we discuss the potential of strategies to manipulate the gut microbiota and metabolites as the therapeutic approach for lung diseases.

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“…Other aspects to be considered in further investigation on effects of dietary modulation of gut microbiota in CF include the influence of other gut microbiota modulating factors such as antibiotics [ 69 ] and gender [ 40 ] on the effect of dietary modulation of gut microbiota by flavonoids, differences in metabolism between strains of the same gut bacterial species [ 68 ], the potential adaptation of phenotypes of particular bacterial species to the CF intestinal environment [ 70 ], and variable individual responses (including timeframe and the extent of changes) to dietary modulation of gut microbiota partially due to different individual baseline diets [ 21 ]. There seems to be associations between gut microbiota variation and some micronutrients in CF [ 31 ]. If both flavonoids and certain micronutrients can modify gut microbiota in CF, it remains to be determined whether the effect is due to individual dietary component or a combination of two or more dietary constituents.…”

Section: Discussionmentioning

confidence: 99%

“…The association between gut microbiota and use of medications such as antibiotics, laxatives, and proton pump inhibitors, and other clinical characteristics such as age, gender, BMI, pulmonary function, and use of probiotics was tested using the same approach. The relationship between gut microbiota and micronutrients was previously reported [ 31 ]. Other results will be reported separately.…”

Section: Methodsmentioning

confidence: 99%

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Associations between Flavonoid Intakes and Gut Microbiota in a Group of Adults with Cystic Fibrosis

Somerset

2018

Nutrients

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Dietary flavonoid intakes can influence gut microbiota (GM), which in turn can affect immune function and host metabolism, both vital considerations in cystic fibrosis (CF) management. In CF, GM may be altered and link to CF respiratory events. This study explored the relationship between flavonoid intakes and GM in free-living adults with CF. Associations between the overall GM variations (unweighted and weighted UniFrac distances between pyrosequencing results of bacterial 16-ss rDNA from frozen faecal samples of sixteen CF adults) and standardised dietary flavonoid intakes (a validated flavonoid-specific food frequency questionnaire) were analysed using adonis tests. Flavonoid intakes that were significant at a false discovery rate (FDR) < 0.3 were subjected to Spearman correlation tests with standardised bacterial relative abundances (FDR < 0.3). Gallocatechin intakes (p = 0.047, q = 0.285) were associated with unweighted UniFrac distances. Intakes of apigenin (p = 0.028, q = 0.227) and kaempferol (p = 0.029, q = 0.227), and % flavonoid intake as flavones (p = 0.013, q = 0.227) and flavonols (p = 0.016, q = 0.227) (both excluding contribution of tea) were associated with weighted UniFrac distances. Among these, gallocatechin correlated with the genus Actinomyces and family Actinomycetaceae (Actinobacteria). Gallocatechin correlated negatively with class Coriobacteriia (Actinobacteria). Intakes of some flavonoids may be associated with GM variations with potential consequences for metabolism, immune function, and inflammation, which are important in CF lung disease and co-morbidity management.

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Associations between micronutrient intakes and gut microbiota in a group of adults with cystic fibrosis

Cited by 56 publications

References 51 publications

Zinc Nutrition and Inflammation in the Aging Retina

Zinc Nutrition and Inflammation in the Aging Retina

The Cross-Talk Between Gut Microbiota and Lungs in Common Lung Diseases

Associations between Flavonoid Intakes and Gut Microbiota in a Group of Adults with Cystic Fibrosis

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