Associations Between Nutritional Deficits and Physical Performance in Community-Dwelling Older Adults

Abstract

Background: Whether multiple nutritional deficiencies have a synergic effect on mobility loss remains unknown. This study aims to evaluate associations between multi-nutritional deficits and physical performance evolution among community-dwelling older adults.Methods: We included 386 participants from the Multidomain Alzheimer Preventive Trial (MAPT) (75.6 ± 4.5 years) not receiving omega-3 polyunsaturated fatty acid (PUFA) supplementation and who had available data on nutritional deficits. Baseline nutritional deficits were defined as plasma 25 hydroxyvitamin D <20 ng/ml, plasma homocysteine >14 μmol/L, or erythrocyte omega-3 PUFA index ≤ 4.87% (lower quartile). The Short Physical Performance Battery (SPPB), gait speed, and chair rise time were used to assess physical performance at baseline and after 6, 12, 24, 36, 48, and 60 months. We explored if nutrition-physical performance associations varied according to the presence of low-grade inflammation (LGI) and brain imaging indicators.Results: Within-group comparisons showed that physical function (decreased SPPB and gait speed, increased chair rise time) worsened over time, particularly in participants with ≥2 nutritional deficits; however, no between-group differences were observed when individuals without deficit and those with either 1 or ≥2 deficits were compared. Our exploratory analysis on nutritional deficit-LGI interactions showed that, among people with ≥2 deficits, chair rise time was increased over time in participants with LGI (adjusted mean difference: 3.47; 95% CI: 1.03, 5.91; p = 0.017), compared with individuals with no LGI.Conclusions: Accumulated deficits on vitamin D, homocysteine, and omega-3 PUFA were not associated with physical performance evolution in older adults, but they determined declined chair rise performance in subjects with low-grade inflammation.Clinical Trial Registration: [https://clinicaltrials.gov/ct2/show/NCT00672685], identifier [NCT00672685].

Effectiveness of fitness and nutritional status on learning outcomes in students penjas fkip islamic university of riau

“…Citation (Lu et al, 2022) explores trends in physical fitness and nutritional status among school-aged children. the relationship between nutritional deficits and physical performance in the elderly has been explored and revealed mixed findings in the literature (Lu et al, 2021). Furthermore, the relationship between 25(OH)D status and changes in performance and physical strength in older adults has been investigated, thus clarifying the impact of nutritional factors on physical abilities (Houston et al, 2012).…”

A 1‐year randomized controlled trial of a nutritional blend to improve nutritional biomarkers and prevent cognitive decline among community‐dwelling older adults: The Nolan Study

“…The effect of intervention was also studied in exploratory analyses according to apolipoprotein E ( APOE ) ε4 status (carrier vs non‐carrier) and to the presence of nutritional deficits at baseline: low ω‐3 index (≤5.69%, lowest quartile) 22 , 23 ; high homocysteine (>14 µmol/L) 23 , 24 ; and low 25 hydroxyvitamin D concentrations (25(OH)D; <20 ng/mL). 23 , 25 For this purpose, a whole blood sample ≥1 mL was collected at baseline for DNA analyses including APOE ε4 status. 25(OH)D concentrations were determined using a commercially available immunoassay kit (Architect 5P02, Abbott).…”

“…<20 ng/mL). 23,25 For this purpose, a whole blood sample ≥1 mL was collected at baseline for DNA analyses including APOE ε4 status.…”

“…The effect of intervention was also studied in exploratory analyses according to apolipoprotein E (APOE) ε4 status (carrier vs noncarrier) and to the presence of nutritional deficits at baseline: low ω-3 index (≤5.69%, lowest quartile) 22,23 ; high homocysteine (>14 µmol/L) 23,24 ; and low 25 hydroxyvitamin D concentrations (25(OH)D;…”