Associations between opioid dependence and sweet taste preference

Garfield, Joshua B.B.; Lubman, Dan I.

doi:10.1007/s00213-021-05774-2

Cited by 7 publications

(3 citation statements)

References 45 publications

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“…These results are compatible with previous research. It has been determined that the sensitivity to low concentrations of sweet taste decreases in individuals treated with opiate‐maintenance therapy (OMT), and the tendency to prefer sweeter flavours increases as opioid use levels increase (Green et al., 2013; Garfield & Lubman, 2021). It has been found that increasing the dose of OMT treatment increases the risk of impaired taste perception by 2.46 times (Greer et al., 2016).…”

Section: Discussionmentioning

confidence: 99%

Diet quality, nutritional status and taste recognition are impaired in men with substance use disorder

Urhan,

Gezmen Karadağ

2023

Nutrition Bulletin

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This study aimed to (1) evaluate the nutritional status, prevalence of malnutrition and dietary habits in individuals using substances and (2) examine the possible effects of substance use on the perception of five basic tastes. Ninety male individuals with substance use disorder (SUD) (heroin = 78, cocaine = 12) and 32 non‐users participated in the study conducted at Manisa Alcohol and Substance Addiction Treatment Center (AMATEM), Turkey. To determine the quality of the diet, the mean nutrient adequacy ratio (MAR) was calculated based on 24‐h recall food consumption records of the individuals. Subjective Global Assessment (SGA) was employed to determine nutritional status, and anthropometric measurements were also taken from the individuals. The taste detection and recognition thresholds were determined with solutions with different concentrations for bitter, sour, sweet, umami and salty tastes and scored, with higher scores indicating lower thresholds. Mild–moderate malnutrition was determined in 50% of the individuals with SUD based on SGA. The body mass index (BMI) of individuals with SUD was found to be 21.2 ± 1.88 kg/m2, and 24.1 ± 1.64 kg/m2 for non‐users (p < 0.001). Diet quality, evaluated by MAR, was lower in individuals with SUD (54.7 ± 18.9%) than in non‐users (93.5 ± 9.0%) (p < 0.001). The taste detection and taste recognition thresholds of individuals with SUD were impaired, and the threshold scores for sour, salty, sweet and umami taste recognition were significantly lower compared with non‐users, with the lowest substance user threshold scores observed for the sweet recognition threshold. Standardised nutritional and behavioural interventions designed by dietitians should be provided for drug users in treatment centres and integrated with medical treatment practices.

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Section: Discussionmentioning

confidence: 99%

Diet quality, nutritional status and taste recognition are impaired in men with substance use disorder

Urhan,

Gezmen Karadağ

2023

Nutrition Bulletin

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“…The sweet taste preference of the SUD population makes it tempting to wonder whether their increased preference and consumption of sugar are associated with changes in gustatory responses. However, several studies on taste perception in SUD populations have shown different results, making it unclear whether SUD causes changes in taste perception that give rise to a preference process for sugar ( 52 – 54 ). These differential results may be attributed to the small sample size of the experiment, as well as differences in gender, age, education level, and income of participants.…”

Section: Ketogenic Diet Decreases the Intake Of Carbohydratesmentioning

confidence: 99%

Ketogenic diet: a potential adjunctive treatment for substance use disorders

Kong,

Sun,

Yang

et al. 2023

Front. Nutr.

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Substance use disorders (SUD) can lead to serious health problems, and there is a great interest in developing new treatment methods to alleviate the impact of substance abuse. In recent years, the ketogenic diet (KD) has shown therapeutic benefits as a dietary therapy in a variety of neurological disorders. Recent studies suggest that KD can compensate for the glucose metabolism disorders caused by alcohol use disorder by increasing ketone metabolism, thereby reducing withdrawal symptoms and indicating the therapeutic potential of KD in SUD. Additionally, SUD often accompanies increased sugar intake, involving neural circuits and altered neuroplasticity similar to substance addiction, which may induce cross-sensitization and increased use of other abused substances. Reducing carbohydrate intake through KD may have a positive effect on this. Finally, SUD is often associated with mitochondrial damage, oxidative stress, inflammation, glia dysfunction, and gut microbial disorders, while KD may potentially reverse these abnormalities and serve a therapeutic role. Although there is much indirect evidence that KD has a positive effect on SUD, the small number of relevant studies and the fact that KD leads to side effects such as metabolic abnormalities, increased risk of malnutrition and gastrointestinal symptoms have led to the limitation of KD in the treatment of SUD. Here, we described the organismal disorders caused by SUD and the possible positive effects of KD, aiming to provide potential therapeutic directions for SUD.

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“…Research on the effects of opioids on sweet taste sensitivity indicates that opioid-dependent individuals exhibit decreased sensitivity to low sweetness 22 . Thus, nicotine in tobacco diminishes sweet taste sensitivity and alters the sweet taste preference of tobacco-dependent individuals, consequently affecting the intake of sweet foods 23,24 .…”

Section: Introductionmentioning

confidence: 99%

Effects of acute aerobic exercise on sweet taste preference and its brain mechanisms in tobacco addicts

Liu,

Han,

Liang

et al. 2024

Preprint

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Aerobic exercise can improve cravings for smoking and inhibition control in tobacco-dependent individuals; however, its effect on their sweet taste preferences remains unclear. This study aims to examine the effects of acute aerobic exercise on sweet taste preferences and nerve sensitivity in brain regions associated with the prefrontal cortex in tobacco-dependent subjects. Participants were asked to perform 35 minutes of exercise or rest. They took the sweet taste preference test and the Visual Food Cues Paradigm Task immediately before and immediately after the experiment. After the intervention with acute high-intensity exercise, participants' preference for low-sweetness foods increased significantly (F = 14.220, P < 0.001). Following the moderate-intensity exercise intervention, when participants were shown pictures of low-sweetness food, the average concentration of oxyhemoglobin in the right orbitofrontal cortex increased significantly (F = 14.215, P < 0.001). Additionally, the change in functional connection strength between the right dorsolateral prefrontal cortex and the left ventrolateral prefrontal cortex was significantly enhanced (F = 4.113, P = 0.046). These results suggest that acute aerobic exercise can alter the sweet taste preferences of tobacco-dependent subjects, as well as the level of PFC activation and functional connectivity, thereby temporarily restoring the nerve sensitivity related to sweet taste that has been impaired by nicotine.

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Associations between opioid dependence and sweet taste preference

Cited by 7 publications

References 45 publications

Diet quality, nutritional status and taste recognition are impaired in men with substance use disorder

Diet quality, nutritional status and taste recognition are impaired in men with substance use disorder

Ketogenic diet: a potential adjunctive treatment for substance use disorders

Effects of acute aerobic exercise on sweet taste preference and its brain mechanisms in tobacco addicts

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