Associations between peri‐implant crevicular fluid volume, concentrations of crevicular inflammatory mediators, and composite IL‐1A –889 and IL‐1B +3954 genotype: A cross‐sectional study on implant recall patients with and without clinical signs of peri‐implantitis

Lachmann, Stefan; Kimmerle‐Müller, Evi; Axmann, Detlef; Scheideler, Lutz; Weber, Heiner; Haas, Robert

doi:10.1111/j.1600-0501.2006.01322.x

Cited by 72 publications

(140 citation statements)

References 56 publications

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“…Varying reports have attempted to associate specific genotypes of the immune response with peri-implantitis. There is some evidence that IL-1 polymorphisms, particularly in conjunction to smoking, may confer an increased risk for peri-implant bone loss or implant loss (61,62), but this may not adequately reflect the produced levels of inflammatory mediators (63)(64)(65). Therefore, to-date no specific genotype or systemic inflammatory marker exists that can reliably indicate peri-implant disease progression or susceptibility (66).…”

Section: Pathogenesis Of Peri-implant Diseasesmentioning

confidence: 99%

Microbiological and immuno-pathological aspects of peri-implant diseases

Belibasakis

2014

Archives of Oral Biology

174

135

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Section: Pathogenesis Of Peri-implant Diseasesmentioning

confidence: 99%

Microbiological and immuno-pathological aspects of peri-implant diseases

Belibasakis

2014

Archives of Oral Biology

174

135

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“…Studies have also demonstrated that single nucleotide polymorphisms (SNP) in the IL-1 gene may hold an increased risk for the development of peri-implantitis, particularly when combined with smoking (Andreiotelli et al 2008;Bormann et al 2010). However, the presence of a specific SNP does not necessarily translate into higher levels of IL-1β in PICF (Lachmann et al 2007;Jansson et al 2005;Melo et al 2012). Although there is good evidence of the involvement of IL-1β as a crucial mediator of the host inflammatory response in peri-implant tissues (Murata et al 2002;Salvi et al 2010;Ataoglu et al 2002), this needs to be complemented with further interventional studies, whereby IL-1β inhibitors are part of the treatment.…”

mentioning

confidence: 99%

Peri-Implant Infections of Oral Biofilm Etiology

Belibasakis

Charalampakis

Bostancı

et al. 2014

Advances in Experimental Medicine and Biology

108

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Biofilms are complex microbial communities that grow on various surfaces in nature. The oral micobiota tend to form polymicrobial biofilms, particularly on the hard mineralized surfaces of teeth, which may impact on oral health and disease. They can cause inflammation of the adjacent tooth-supporting (periodontal) tissues, leading to destructive periodontal disease and tooth loss. The emergence of osseointegrated dental implants as a restorative treatment option for replacing missing teeth has also brought along new artificial surfaces within the oral cavity, on which oral bacteria can form biofilms. As in the case of natural teeth, biofilms on implant surfaces may also trigger infection and cause inflammatory destruction of the peri-implant tissue (i.e. peri-implantitis). While there are strong similarities in the composition of the mixed microbial flora between periodontal and peri-implant infections, there are also a few distinctive differences. The immunological events underlying the pathogenesis of peri-implant infections are qualitatively similar, yet more extensive, compared to periodontal infections, resulting in a faster progression of tissue destruction. This chapter summarizes the current knowledge on the microbiology and immunology of peri-implant infections, including findings from the peri-implant crevicular fluid, the inflammatory exudate of the peri-implant tissue. Moreover, it discusses the diagnosis and current approaches for the treatment of oral infections.

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“…Some studies concentrated on the issue of the relationship between this gene polymorphism and risk factors for dental implant failure (Lachmann et al 2007;Lin et al 2007;Rogers et al 2002;Shimpuku et al 2003). Rogers et al (2002) observed no association between IL-1A-889 and IL-1B?3953 alleles or the composite genotype and the failure of dental implants.…”

Section: Resultsmentioning

confidence: 99%

Biological Factors Involved in Implant-Anchored Orthodontics and in Prosthetic-Implant Therapy: A Literature Review

Antoszewska

Raftowicz−Wójcik

Kawala

et al. 2010

Arch. Immunol. Ther. Exp.

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During the past few years, the application of orthodontic miniscrews and dental implants has been expanded. However, failures have necessitated ongoing investigation of potential risk factors. The aim of this overview was to conduct an assessment of the immunological response following application of cortical temporary anchorage devices--titanium miniscrew implants--in orthodontic patients. A scrupulous search of the database revealed only two matching items; therefore studies evaluating the immune response subsequent to insertion of dental implants were reviewed. Thorough assessment revealed the following as factors associated with dental implant rejection: (1) correlation of the volume of gingival and peri-implant crevicular fluid and the amount of interleukin (IL)-1beta with mucosal inflammation, thus serving as a peri-implantitis evaluation index; (2) significantly more frequent marginal bone loss around implants in patients with IL-1B-511 2/2 genotype; (3) humoral response to Staphylococcus aureus. However, since there is almost no evidence-based evaluation of the allergic/inflammatory reaction either to orthodontic titanium miniscrews themselves or in adolescents and young adults, who comprise the largest group of orthodontic patients, this issue requires further investigation. It is essential in order to achieve successful, sophisticated and modern treatment of malocclusions.

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Associations between peri‐implant crevicular fluid volume, concentrations of crevicular inflammatory mediators, and composite IL‐1A –889 and IL‐1B +3954 genotype: A cross‐sectional study on implant recall patients with and without clinical signs of peri‐implantitis

Abstract: The Interleukin-1 polymorphism investigated exerted only little influence on the peri-implant crevicular immune response, and this influence appeared to be of limited impact in sites with established peri-implantitis lesions.

Cited by 72 publications

References 56 publications

Microbiological and immuno-pathological aspects of peri-implant diseases

Microbiological and immuno-pathological aspects of peri-implant diseases

Peri-Implant Infections of Oral Biofilm Etiology

Biological Factors Involved in Implant-Anchored Orthodontics and in Prosthetic-Implant Therapy: A Literature Review

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