2003
DOI: 10.1902/annals.2003.8.1.54
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Associations Between Periodontal Disease and Risk for Nosocomial Bacterial Pneumonia and Chronic Obstructive Pulmonary Disease. A Systematic Review

Abstract: 1. Oral colonization by respiratory pathogens, fostered by poor oral hygiene and periodontal diseases, appears to be associated with nosocomial pneumonia. 2. Additional large-scale RCTs are warranted to provide the medical community with further evidence to institute effective oral hygiene procedures in high-risk patients to prevent nosocomial pneumonia. 3. The results associating periodontal disease and COPD are preliminary and large-scale longitudinal and epidemiologic and RCTs are needed.

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Cited by 415 publications
(358 citation statements)
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“…[117][118][119] This population is commonly colonized with pulmonary pathogens and has higher incidences of both community-acquired and health care-associated pneumonia. 120 In a study of the homeless in Los Angeles, 58% had severe, untreated dental caries. 118 Sixty-five percent of ICU subjects had dental plaque/oral mucosa colonized with pulmonary pathogens, with an ϳ10-fold increased risk for pneumonia during the first 6 d of ICU stay.…”
Section: Impact Of Poverty and Homelessnessmentioning
confidence: 99%
See 1 more Smart Citation
“…[117][118][119] This population is commonly colonized with pulmonary pathogens and has higher incidences of both community-acquired and health care-associated pneumonia. 120 In a study of the homeless in Los Angeles, 58% had severe, untreated dental caries. 118 Sixty-five percent of ICU subjects had dental plaque/oral mucosa colonized with pulmonary pathogens, with an ϳ10-fold increased risk for pneumonia during the first 6 d of ICU stay.…”
Section: Impact Of Poverty and Homelessnessmentioning
confidence: 99%
“…118 Sixty-five percent of ICU subjects had dental plaque/oral mucosa colonized with pulmonary pathogens, with an ϳ10-fold increased risk for pneumonia during the first 6 d of ICU stay. 120 Oral chlorhexidine or topical antibiotic (selective decontamination) therapy has been reported to reduce the incidence of nosocomial pneumonia by an average of 40%, with the highest reduction (69%) reported in postoperative cardiac surgery subjects. 121,122 However, a recent metaanalysis of oral chlorhexidine treatment suggests that it does not reduce the incidence of VAP in the general ICU population.…”
Section: Impact Of Poverty and Homelessnessmentioning
confidence: 99%
“…Among those, periodontal diseases are complex polymicrobial inflammatory diseases associated with dysbiosis of the dental biofilm that induces a long-lasting chronic inflammation of the periodontal supporting tissues, leading to alveolar bone destruction, and eventual tooth loss [6]. Over the years, strong evidence has accumulated to indicate that the pathogenic microbiota and the chronic inflammation established in periodontitis contribute to the onset and/or progression of several systemic inflammatory diseases such as cardiovascular diseases [7,8], diabetes [9], obesity [10], metabolic syndrome [11], respiratory disease [12], cancer [13], chronic kidney disease (CKD) [14] and rheumatoid arthritis (RA) [15]. Most research on the periodontitis-systemic disease relationship, however, has not determined causality, and the link between these diseases are bi-directional associations [16].…”
Section: Introductionmentioning
confidence: 99%
“…Cognitive impairment, stroke, or other conditions that imply incompetent swallowing are the main risk factors for aspirating foreign material (van der Maarel-Wierink et al 2011). Ventilated patients are also at risk, even when not aged (Scannapieco et al 2003). In a prospective study, 10% of 1499 community-dwelling patients who were hospitalized for pneumonia presented with aspiration pneumonia, whereas this percentage rose to 30% in 447 institutionalized pneumonia patients from the same study (Shariatzadeh et al 2006).…”
Section: Pneumonia: the Leading Cause Of Death From Infection In Eldersmentioning
confidence: 99%