Associations between peripheral blood eosinophil counts in patients with systemic sclerosis and disease severity

Ando, Kenji; Nakashita, Tamao; Kaneko, Norihiro; Takahashi, Kazuhisa; Motojima, Seiji

doi:10.1186/s40064-016-3106-4

Cited by 12 publications

(23 citation statements)

References 25 publications

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“…First, because PBC and ILD were reported to be sometimes accompanied by eosinophilia, frequency of eosinophilia was determined in our patients with PBC or ILD. As a result, there was no statistically significant difference in the peripheral blood eosinophil counts (median, 230 vs 270/mm 3 ; P = 0.8472) or eosinophil percentages (median, 6.9% vs 5.0%; P = 0.2223) between patients with or without PBC (Fig.…”

Section: Resultssupporting

confidence: 91%

“…There were three findings in this retrospective study. First, consistent with the previous report, peripheral blood eosinophil counts in patients with ILD tended to be increased compared with those without. The authors of the report speculated that eosinophilia may be associated with the inflammation of scleroderma‐related ILD, and peripheral blood eosinophil counts may be affected by the eosinophil accumulation in the lung.…”

Section: Discussionmentioning

confidence: 68%

“…b). Consistent with the previous report, eosinophil counts in patients with ILD tended to be increased compared with those without, albeit statistically insignificant (median, 343 vs 270/mm 3 ; P = 0.0511; Fig. c).…”

Section: Resultsmentioning

confidence: 99%

“…In the peripheral blood, an eosinophil count of more than 300/mm 2 or more than 1000 mm 2 can be seen in 16% or 1% of patients with SSc, respectively, and frequency of eosinophilia in SSc patients was thought to be higher than that in other connective tissue diseases . Consistently, circulating levels of ECP showed fourfold increase in SSc patients compared with healthy subjects.…”

Section: Introductionmentioning

confidence: 99%

“…Consistently, circulating levels of ECP showed fourfold increase in SSc patients compared with healthy subjects. As for the clinical significance of peripheral blood eosinophilia in SSc patients, Ando et al . analyzed 70 patients, and reported that it was correlated with the presence of interstitial lung disease (ILD), severe skin sclerosis and skin pruritus.…”

Section: Introductionmentioning

confidence: 99%

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Peripheral blood eosinophilia is associated with the presence of skin ulcers in patients with systemic sclerosis

Hara

Ikeda

Inaba

et al. 2019

The Journal of Dermatology

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The role of eosinophil in systemic sclerosis (SSc) is still controversial. In the present study, the relationship between skin ulcers and peripheral blood eosinophilia were analyzed in patients with SSc. We retrospectively investigated the clinical records of all patients who were diagnosed with SSc on the basis of American College of Rheumatology/European League Against Rheumatism 2013 criteria, and were followed up for more than 2 years at Wakayama Medical University. As a result, maximum eosinophil counts during the 2‐year follow‐up period were 20–983/mm3 (median, 270), whereas maximum eosinophil percentages were 0.5–14.1% (median, 5.3%) in peripheral blood of 47 SSc patients. On the other hand, patients with skin ulcers during the 2‐year follow up showed significantly increased maximum eosinophil counts compared with those without (median, 520 vs 228/mm3; P = 0.0001). Maximum eosinophil percentage was also significantly higher in patients with skin ulcers (median, 9.7% vs 4.6%; P = 0.00001). To note, in four of the nine patients with skin ulcers, the timing of emerging of the maximum eosinophil counts was associated with the ulcer development during the 2‐year follow up. These results suggest that eosinophils are involved in the pathogenesis of vascular dysfunction of SSc. Larger studies should be performed to clarify the exact mechanism of ulcer formation caused by eosinophilia in SSc patients in the future.

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Section: Resultssupporting

confidence: 91%

Section: Discussionmentioning

confidence: 68%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Peripheral blood eosinophilia is associated with the presence of skin ulcers in patients with systemic sclerosis

Hara

Ikeda

Inaba

et al. 2019

The Journal of Dermatology

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Serum CCL24 as a Biomarker of Fibrotic and Vascular Disease Severity in Systemic Sclerosis

De Lorenzis,

Mor,

Ross

et al. 2024

Arthritis Care & Research

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BackgroundSystemic sclerosis (SSc) is a heterogeneous disease, characterized by variable tissue and vascular fibrosis in the context of autoimmune activation. The C‐C Motif Chemokine Ligand 24 (CCL24 or Eotaxin2) has been shown to promote microangiopathic, pro‐inflammatory, and pro‐fibrotic processes in preclinical models of SSc. Here we study serum CCL24 levels in a real‐life cohort of SSc patients, to determine its distribution across disease features and its value in predicting disease progression and related mortality.MethodsSerum CCL24 was assessed in an observational cohort of consecutively enrolled SSc patients. A high CCL24 cut‐off was defined based on its distribution in a matched cohort of healthy controls. Disease progression and mortality were analysed from the date of serum assessment.ResultsTwo‐hundred‐thirteen consecutively enrolled patients with SSc were included in this analysis. Median disease duration was 6 years (IQR 3‐14), 28.6% of patients presented with interstitial lung disease (ILD), 46.9% had digital ulcers and 25.3% showed high CCL24 serum concentration. High CCL24 patients were more frequently male, with anti‐SCL‐70 positive, with a diagnosis of ILD and synovitis (p<0.05 for all). Notably, high CCL24 patients had lower DLco and higher prevalence of digital ulcers, telangiectasias, and calcinosis (p<0.05 for all). In a longitudinal setting, high CCL24 was associated with greater lung function decline and with higher disease‐related mortality.ConclusionSerum CCL24 is a biomarker of disease severity across fibrotic and vascular disease manifestations. These data support the development of therapies targeting CCL24 as a novel comprehensive therapeutic target in SSc.

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Computed Tomography Findings as Determinants of Local and Systemic Inflammation Biomarkers in Interstitial Lung Diseases: A Retrospective Registry-Based Descriptive Study

Lang

Akbari

Hörner

et al. 2021

Lung

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Purpose To evaluate the association of peripheral blood (PBL) and broncho-alveolar lavage (BAL) biomarkers with inflammatory versus fibrotic high-resolution computed tomography (HRCT) findings in interstitial lung disease (ILD) patients. Methods HRCT findings of 127 consecutive ILD-board patients were semi-quantitatively evaluated: reticulation/honeycombing (RET), traction bronchiectasis (TBR) and emphysema (EMP) were classified as non-inflammatory/fibrotic; consolidations (CON), ground glass opacities (GGO), parenchymal nodules (NDL) and mosaic attenuation (MOS) as active inflammatory. Each HRCT finding was assessed in six distinct lung regions, resulting scores were graded as minimal (0–1 regions involved), medium (2–4) or extensive (5–6). Associations of routinely assessed PBL/BAL biomarkers with these HRCT scores were evaluated using Spearman correlation coefficients and graphical presentation; significance was tested by applying Kruskal–Wallis tests. Results Blood neutrophil, lymphocyte and eosinophil fraction, neutrophil to lymphocyte ratio (NLR) and BAL lymphocyte fraction consistently showed opposite correlations with inflammatory versus non-inflammatory/fibrotic HRCT finding scores. Blood lymphocyte fraction significantly differed by graded GGO (p = 0.032) and CON (p = 0.027) extent, eosinophil fraction by TBR (p = 0.006) and NLR by CON (p = 0.009). C-reactive protein was significantly related to GGO (p = 0.023) and CON (p = 0.004), BAL lymphocyte fraction to GGO (p = 0.017) extent. Conclusion Blood lymphocyte and eosinophil fraction, NLR, CRP and BAL lymphocyte fraction may aid to differentiate inflammatory from non-inflammatory/fibrotic ILD patterns. Trial registration This evaluation was based on data from the ILD registry of Kepler University Hospital Linz, as approved by the ethics committee of the Federal State of Upper-Austria (EK Number. I-26-17).

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Associations between peripheral blood eosinophil counts in patients with systemic sclerosis and disease severity

Cited by 12 publications

References 25 publications

Peripheral blood eosinophilia is associated with the presence of skin ulcers in patients with systemic sclerosis

Peripheral blood eosinophilia is associated with the presence of skin ulcers in patients with systemic sclerosis

Serum CCL24 as a Biomarker of Fibrotic and Vascular Disease Severity in Systemic Sclerosis

Computed Tomography Findings as Determinants of Local and Systemic Inflammation Biomarkers in Interstitial Lung Diseases: A Retrospective Registry-Based Descriptive Study

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