IntroductionCommercial salmon fishing in Alaska is one of the most dangerous occupations in the United States. Between 1992 and 2008, the average annual industry mortality rate was 128 deaths per 100,000 workers [1], and despite an increase in industry regulations, there has not been a significant decrease in mortality rate since 2000 [2]. The majority of recorded injuries and mortality result from on-deck injuries, particularly those involving machinery, and falls overboard [2]. The industry is calling for injury prevention efforts such as increased use of personal flotation devices, but efforts to date have proven minimally successful.Studies have demonstrated a significant, positive relationship between sleep deprivation and response time and vigilant attention [3]. Sleep deprivation has also been shown to decrease resilience to stress and to have a detrimental impact on complex reasoning and decision making [4]. Unpredictable fishing openings and fierce competition for limited resources result in periods of intense sleep deprivation and physical strain during the short commercial salmon seasons in Alaska. Work is often highly physically demanding, requiring regular lifting and pulling of heavy items as well as repetitive movements associated with picking fish from nets, which is performed at high speeds and often for hours at a time. While the industry is currently focused on reducing acute morbidity and mortality, chronic stress, sleep deprivation, and the maintenance of high levels of physical exertion may also contribute to morbidity later in life through increased cardiometabolic risk [5]. We hypothesize that the combined effect of sleep deprivation, intense physical workload and significant short-term chronic stress may be deleterious to health in both the short and long-term among commercial salmon drift gillnet fisherman in Alaska.In order to identify the physical and physiological impacts of commercial fishing on individuals, we intend to complete a mixed methods study designed to elucidate the ways in which sleep deprivation and chronic stress impact the short and long-term health of industry participants. Advancements in biometrics of activity, movement, and physiology in combination with biomarkers of acute and chronic psychosocial stress can provide insight into how the lifestyle and occupational factors associated with commercial fishing may negatively impact both the physical and psychological health of fishermen, while observational data can provide context into the daily activities and environmental pressures inherent to the industry.Biometric devices provide an objective method for quantifying physical activity. Measuring physical activity and sleep deprivation has proven historically challenging, and traditionally has been performed using self-report via physical activity questionnaires. While cheap and relatively easy to administer [6,7], physical activity questionnaires are incapable of objectively quantifying physical activity and, due to self-report, are inherently unreliable. One study...