Associations between plasma metal levels and mild renal impairment in the general population of Southern China

Lv, Ziquan; Fu, Xuejun; Zheng, Sijia; Yang, Zhijun; Zou, Xuan; Liu, Yuewei; Zhang, Yanwei; Wen, Ying; Lu, Qi; Huang, Hui; Huang, Suli; Liu, Ran

doi:10.1016/j.ecoenv.2022.114209

Cited by 6 publications

(1 citation statement)

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“…The nephrotoxic effects of mixtures of metals have been reported recently in general population of adults and children. In Southern China, higher concentrations mixtures of As and Mo in plasma of adult patients attending a hospital were associated with mild renal impairment [49]. Another study in Chinese adults with diabetes showed that higher concentrations of metal mixtures in urine, particularly As and V, were associated with chronic kidney disease [50].…”

Section: Discussionmentioning

confidence: 99%

Chemical Element Mixtures and Kidney Function in Mining and Non-Mining Settings in Northern Colombia

Villamizar

Medina

Flórez-Vargas

et al. 2023

IJERPH

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The exposure to chemical mixtures is a problem of concern in developing countries and it is well known that the kidney is the major target organ for toxic elements. This cross-sectional study aimed to estimate the individual and composite mixture effect of a large number of chemical elements on kidney function in gold-mining and surrounding non-mining populations in northeast Colombia. We measured concentrations of 36 chemical elements in hair as indicators of chronic exposure from 199 adult participants. We estimated the effect of exposure to mixtures of chemical elements on estimated glomerular filtration rate (eGFR) using weighted quantile sum regression (WQS). The WQS index of the mixture was associated with reduced eGFR (Coefficient −2.42; 95%CI: −4.69, −0.16) being Be, Cd, Pb, As, and Mn, the principal contributors of the toxic mixture. Mining activities and Hg concentration were not associated with decreased kidney function. Our results suggest that complex mixtures of chemical elements, mainly heavy metals, act as nephrotoxic in these populations and therefore the analysis of chemical element mixtures is a better approach to identify environmental and occupational chemical risks for kidney damage.

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Section: Discussionmentioning

confidence: 99%