Associations between PM2.5 exposure and infant growth: A mediation analysis of oral microbiota

Wu, Hanning; Dong, Chao; Xiao, Wenwen; Wei, Hongcheng; Shao, Yunmin; Chen, Ting; Xia, Yankai

doi:10.1016/j.scitotenv.2022.153688

Cited by 9 publications

(5 citation statements)

References 64 publications

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“…Oral hygiene-related bacteria were compared with NPC-related bacteria, and consistent bacteria were selected as mediator candidates. By referring to relevant literature, arcsine square root transformation was performed to improve the normality of the relative abundance values of mediator candidates [ 39 , 40 , 41 ]. Mediation analysis was performed using the “mediation” package in R and corrected for age, sex, educational level, cigarette smoking and alcohol drinking status.…”

Section: Methodsmentioning

confidence: 99%

The Oral Microbiome as Mediator between Oral Hygiene and Its Impact on Nasopharyngeal Carcinoma

Liu

Liao

et al. 2023

Microorganisms

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Oral hygiene and the alteration of the oral microbiome have been linked to nasopharyngeal carcinoma (NPC). This study aimed to investigate whether the oral microbiome plays a mediating role in the relationship between oral hygiene and NPC, and identify differential microbial taxonomies that potentially mediated this association. We conducted a case–control study that involved 218 NPC patients and 192 healthy controls. The 16S rRNA gene sequencing of the V4 region was performed to evaluate the composition of the oral microbiome. Mediation analysis was applied to explore the relationship among oral hygiene, the oral microbiome and NPC. We found that dental fillings and poor oral hygiene score were associated with increased risks of NPC (OR = 2.51 (1.52–4.25) and OR = 1.54 (1.02–2.33)). Mediation analysis indicated that dental fillings increased the risk of NPC by altering the abundance of Erysipelotrichales, Erysipelotrichaceae, Solobacterium and Leptotrichia wadei. In addition, Leptotrichia wadei also mediated the association between oral hygiene score and the risk of NPC. Our study confirmed that poor oral hygiene increased the risk of NPC, which was partly mediated by the oral microbiome. These findings might help us to understand the potential mechanism of oral hygiene influencing the risk of NPC via the microbiome.

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Section: Methodsmentioning

confidence: 99%

The Oral Microbiome as Mediator between Oral Hygiene and Its Impact on Nasopharyngeal Carcinoma

Liu

Liao

et al. 2023

Microorganisms

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“…In the previous sections, we have already summarized that postnatal exposure to ambient air pollution was associated with early alterations of oral and nasal microbiota. 40 , 69 The Southern California Mother's Milk Study also provide evidence that postnatal ambient air pollution was associated with the balance of the gut microbiota among six-month infants. 76 These findings, although the sample size of these studies was generally small, indicated that postnatal exposure to ambient air pollution could alter microbiome dysbiosis in human beings.…”

Section: Ambient Air Pollution and Other Relevant Outcomesmentioning

confidence: 99%

“… 67 , 68 Megasphaera might function as mediator in the association between early postnatal PM 2.5 exposure during birth−3rd month and abnormal infant growth at one year age, which are Gram-negative anaerobes enriched in people with metabolic syndromes, contributing to the microbial community of saliva, tongue dorsum and tonsils. 69 In addition, molecular adaptations in placental mitochondrial DNA and mitochondrial mutational load were associated with postnatal consequence of abnormal infant growth induced by prenatal exposure to NO 2 70 or PM 2.5 . 71 , 72 Further studies are warranted to establish whether these epigenetic, microbial and molecular variability could explain the influence of ambient air pollution on infant growth.…”

Section: Ambient Air Pollution and Early Infant Growthmentioning

confidence: 99%

Ambient air pollution and infant health: a narrative review

Lin

Chen

et al. 2023

eBioMedicine

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“…Infant growth was negatively associated with the oral microbial diversity, and positively associated with the Firmicutes-to-Bacteroidetes ratio of the oral microbiota ( Craig et al, 2018 ). Megasphaera in oral was demonstrated as a significant mediator between PM 2.5 exposure and restricted infant growth in the first 3 months after birth ( Wu et al, 2022 ). Although the research related to oral microbiome and infant growth were limited until now compared with gut microbiome, these existed results indicated a similar utility and potential of oral microbiome with gut microbiome as an indicator of neonatal growth.…”

Section: Assessment Of Infant Development and Nutritional Status Base...mentioning

confidence: 99%

Maternal and infant microbiome: next-generation indicators and targets for intergenerational health and nutrition care

Gao

Wang

2023

Protein &Amp; Cell

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Microbes are commonly sensitive to shifts in the physiological and pathological state of their hosts, including mothers and babies. From this perspective, the microbiome may be a good indicator for diseases during pregnancy and has the potential to be used for perinatal health monitoring. This is embodied in the application of microbiome from multi body sites for auxiliary diagnosis, early prediction, prolonged monitoring, and retrospective diagnosis of pregnancy and infant complications, as well as nutrition management and health products developments of mothers and babies. Here we summarized the progress in these areas and explained that the microbiome of different body sites is sensitive to different diseases and their microbial biomarkers may overlap between each other, thus we need to make a diagnosis prudently for those diseases. Based on the microbiome variances and additional anthropometric and physical data, individualized responses of mothers and neonates to meals and probiotics/prebiotics were predictable, which is of importance for precise nutrition and probiotics/prebiotics managements and developments. Although a great deal of encouraging performance was manifested in previous studies, the efficacy could be further improved by combining multi-aspect data such as multi-omics and time series analysis in the future. This review reconceptualizes maternal and infant health from a microbiome perspective, and the knowledge in it may inspire the development of new options for the prevention and treatment of adverse pregnancy outcomes and bring a leap forward in perinatal health care.

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Associations between PM2.5 exposure and infant growth: A mediation analysis of oral microbiota

Cited by 9 publications

References 64 publications

The Oral Microbiome as Mediator between Oral Hygiene and Its Impact on Nasopharyngeal Carcinoma

The Oral Microbiome as Mediator between Oral Hygiene and Its Impact on Nasopharyngeal Carcinoma

Ambient air pollution and infant health: a narrative review

Maternal and infant microbiome: next-generation indicators and targets for intergenerational health and nutrition care

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