Associations between Polymorphisms in the &lt;b&gt;&lt;i&gt;IL-1&lt;/i&gt;&lt;/b&gt; Gene and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus: Evidence from a Meta-Analysis

Zhu, Lin; Chen, Peng; Sun, Xuanjing; Zhang, Shuo

doi:10.1159/000510641

Cited by 11 publications

(7 citation statements)

References 46 publications

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“…Furthermore, an ethnicity-specific meta-analysis suggested that the IL-1B −511 C/T polymorphism was associated with RA susceptibility in Caucasians, whereas the IL-1B +3953 C/T polymorphism was associated with susceptibility to RA in Caucasian and in Asian populations [17]. Other studies found that IL-1B +3954 polymorphism was significantly associated with the risk of RA in the overall population and in Asian people [18,19]. Furthermore, an analysis conducted in the Japanese population revealed that individuals affected with both RA and periodontitis may display different distributions of IL-1B +3954 genotypes than healthy controls and subjects with periodontitis only [20].…”

Section: Il-1β the Badmentioning

confidence: 99%

Ultra-Low Dose Cytokines in Rheumatoid Arthritis, Three Birds with One Stone as the Rationale of the 2LARTH® Micro-Immunotherapy Treatment

Jacques¹,

Floris²,

Lejeune³

2021

IJMS

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Tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) are two cytokines involved in the perpetuation of the chronic inflammation state characterizing rheumatoid arthritis (RA). Significant advances in the treatment of this pathology have been made over the past ten years, partially through the development of anti-TNF and anti-IL-1 therapies. However, major side effects still persist and new alternative therapies should be considered. The formulation of the micro-immunotherapy medicine (MIM) 2LARTH® uses ultra-low doses (ULD) of TNF-α, IL-1β, and IL-2, in association with other immune factors, to gently restore the body’s homeostasis. The first part of this review aims at delineating the pivotal roles played by IL-1β and TNF-α in RA physiopathology, leading to the development of anti-TNF and anti-IL-1 therapeutic agents. In a second part, an emphasis will be made on explaining the rationale of using multiple therapeutic targets, including both IL-1β and TNF-α in 2LARTH® medicine. Particular attention will be paid to the ULD of those two main pro-inflammatory factors in order to counteract their overexpression through the lens of their molecular implication in RA pathogenesis.

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Section: Il-1β the Badmentioning

confidence: 99%

Ultra-Low Dose Cytokines in Rheumatoid Arthritis, Three Birds with One Stone as the Rationale of the 2LARTH® Micro-Immunotherapy Treatment

Jacques¹,

Floris²,

Lejeune³

2021

IJMS

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“…Zhu et al (12) , concluyen que tres variantes polimórficas asociadas a la interleucina 1 (IL-1) tienen relación con LES, esta es una citocina de tipo proinflamatoria que se conoce tiene implicación en la iniciación y desarrollo de enfermedades autoinmunes conllevando a un estado proinflamatorio, sin embargo, sugieren más estudios para validación. Por su parte Zhu X et al (26) determinaron que el SNP de la interleucina 33 (IL-33), un nuevo tipo de interleucina considerada parte de la familia de IL-1, aumenta el riesgo de LES al inducir inflamación crónica, además establecieron que el tabaquismo tiene un papel de interacción considerable al incrementar el riesgo de la enfermedad.…”

Section: Lupus Eritematoso Sistémicounclassified

“…(7) La autoinmunidad se encuentra estrictamente asociada a alteraciones genéticas responsables de la pérdida de tolerancia y el desarrollo de autoanticuerpos, (8) teniendo una mayor predisposición de heredabilidad los gemelos monocigotos; estos factores genéticos promueven polimorfismos asociados al sistema de complemento, regiones del antígeno leucocitario humano, interleucinas, proteínas del tipo tirosina fosfatasa, lectina de unión a manosa, afección de nucleótidos simples, entre otras. (8,9,10,11,12) El objetivo de este estudio es determinar los polimorfismos genéticos predisponentes al desarrollo de lupus eritematoso sistémico a través de una revisión bibliográfica.…”

Section: Introductionunclassified

Genetic polymorphisms predisposing to the development of Systemic Lupus Erythematosus

Vásquez

Portilla

2023

Salud, Ciencia y Tecnología

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Introduction: Systemic Lupus Erythematosus is an autoimmune disease with a very heterogeneous clinical presentation mediated by both environmental and genetic factors, it is predominantly female with a 9:1 ratio compared to males, as well as by Afro-descendant ethnic groups, Asian and Hispanic; its pathogenesis is mediated by polymorphic variants of different genes that provide susceptibility to this disease and that have been related to different clinical characteristics, among the most notable are lupus nephritis, cardiovascular diseases, while its treatment is not established. Objective: to determine the genetic polymorphisms predisposing to the development of Systemic Lupus Erythematosus. Methodology: the PubMed search engine was used together with Boolean operators and descriptors in the English language. Based on the search results, the articles to be included in the review were determined by selection according to involvement in the subject. Results: sixteen genetic polymorphisms involved in the pathogenesis of systemic lupus erythematosus were found. Conclusion: polymorphisms explain the predisposition for the female sex, as well as the development of more severe clinical manifestations, highlighting lupus nephritis in specific ethnic groups such as Afro-descendants.

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“…Furthermore, the neuronal type I IL-1 receptor (nIL-1R1) can utilize different coreceptors for signal transduction, IL-1 excites neurons without activating the transcription of inflammatory cytokines in the nuclear factor kappa B (NF-κB) pathway [ 59 ]. Studies have also shown that IL-1A + polymorphisms may affect RA risk in the overall population, while IL-1B+ polymorphisms may affect RA risk in the general and Asian populations [ 60 ]. However, how IL-1 participates in RA pathogenesis via the CNS and potential treatments require further study.…”

Section: Cns Modulation Of Ramentioning

confidence: 99%

“…IL-1A+ polymorphisms have also been linked to an increased incidence of RA in the general population, while IL-1B+ polymorphisms may affect RA risk in the general and Asian populations [ 60 ]. However, how IL-1 participates in RA pathogenesis via the CNS and potential treatments require further study [ 54 ].…”

Section: Cns Modulation Of Ramentioning

confidence: 99%

Neuroimmune Crosstalk in Rheumatoid Arthritis

Gao

Yang

et al. 2022

IJMS

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Recent studies have demonstrated that immunological disease progression is closely related to abnormal function of the central nervous system (CNS). Rheumatoid arthritis (RA) is a chronic, inflammatory synovitis-based systemic immune disease of unknown etiology. In addition to joint pathological damage, RA has been linked to neuropsychiatric comorbidities, including depression, schizophrenia, and anxiety, increasing the risk of neurodegenerative diseases in life. Immune cells and their secreted immune factors will stimulate the peripheral and central neuronal systems that regulate innate and adaptive immunity. The understanding of autoimmune diseases has largely advanced insights into the molecular mechanisms of neuroimmune interaction. Here, we review our current understanding of CNS comorbidities and potential physiological mechanisms in patients with RA, with a focus on the complex and diverse regulation of mood and distinct patterns of peripheral immune activation in patients with rheumatoid arthritis. And in our review, we also discussed the role that has been played by peripheral neurons and CNS in terms of neuron mechanisms in RA immune challenges, and the related neuron-immune crosstalk.

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Associations between Polymorphisms in the <b><i>IL-1</i></b> Gene and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus: Evidence from a Meta-Analysis

Cited by 11 publications

References 46 publications

Ultra-Low Dose Cytokines in Rheumatoid Arthritis, Three Birds with One Stone as the Rationale of the 2LARTH® Micro-Immunotherapy Treatment

Ultra-Low Dose Cytokines in Rheumatoid Arthritis, Three Birds with One Stone as the Rationale of the 2LARTH® Micro-Immunotherapy Treatment

Genetic polymorphisms predisposing to the development of Systemic Lupus Erythematosus

Neuroimmune Crosstalk in Rheumatoid Arthritis

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