Associations between prenatal exposure to phthalates and birth weight: A meta-analysis study

Jin, Shihao; Cui, Shiyong; Xu, Jinghan; Zhang, Xin

doi:10.1016/j.ecoenv.2023.115207

Cited by 6 publications

(1 citation statement)

References 93 publications

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“…Phthalates can easily cross the placental barrier and impact the developing fetus in utero [ 7 ]. Growing literatures have reported that prenatal exposure to phthalates were associated with the risk of multiple adverse pregnancy outcomes, including preterm birth [ 13 , 14 ], spontaneous pregnancy loss [ 15 , 16 ], low birth weight [ 17 ], male newborn genital anomalies [ 18 ], and fetal retarded growth [ 19 ]. Two animal experiment have observed that BBP or DBP exposure could cause abnormalities in zebrafish embryo morphology, including cardiac structure deformities [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Association of maternal phthalates exposure and metabolic gene polymorphisms with congenital heart diseases: a multicenter case-control study

Li,

Kang,

Liu

et al. 2024

BMC Pregnancy Childbirth

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Background The majority of congenital heart diseases (CHDs) are thought to result from the interactions of genetics and the environment factors. This study aimed to assess the association of maternal non-occupational phthalates exposure, metabolic gene polymorphisms and their interactions with risk of CHDs in offspring. Methods A multicenter case-control study of 245 mothers with CHDs infants and 268 control mothers of health infant was conducted from six hospitals. Maternal urinary concentrations of eight phthalate metabolites were measured by ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS). Twenty single nucleotide polymorphisms (SNPs) in cytochrome P450 family 2 subfamily C member 9 (CYP2C9) and 19 (CYP2C19), uridine diphosphate (UDP) glucuronosyl transferase family 1 member A7 (UGT1A7), family 2 member B7 (UGT2B7) and B15(UGT2B15) genes were genotyped. The multivariate logistic regressions were used to estimate the association between maternal phthalates exposure or gene polymorphisms and risk of CHDs. Generalized multifactor dimensionality reduction (GMDR) was used to analyze the gene–gene and gene–phthalates exposure interactions. Results There was no significant difference in phthalate metabolites concentrations between the cases and controls. No significant positive associations were observed between maternal exposure to phthalates and CHDs. The SNPs of UGT1A7 gene at rs4124874 (under three models, log-additive: aOR = 1.74, 95% CI:1.28–2.37; dominant: aOR = 1.86, 95% CI:1.25–2.78; recessive: aOR = 2.50, 95% CI: 1.26–4.94) and rs887829 (under the recessive model: aOR = 13.66, 95% CI: 1.54–121) were significantly associated with an increased risk of CHDs. Furthermore, the associations between rs4124874 (under log-additive and dominant models) of UGT1A7 were statistically significant after the false discovery rate correction. No significant gene-gene or gene-phthalate metabolites interactions were observed. Conclusions The polymorphisms of maternal UGT1A7 gene at rs4124874 and rs887829 were significantly associated with an increased risk of CHDs. More large-scale studies or prospective study designs are needed to confirm or refute our findings in the future.

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