Associations Between RASSF1A Promoter Methylation and NSCLC: A Meta-analysis of Published Data

Abstract

Background: RASSF1A has been reported to be a candidate tumor suppressor in non-small cell lung cancer (NSCLC). However, the association between RASSF1A promoter methylation and NSCLC remains unclear, particularly in regarding links to clinicopathologic features. Methods: Eligible studies were identified through searching PubMed, EMBASE, Cochrane Library and China National Knowledge Infrastructure (CNKI) databases. Studies were pooled and odds ratios (ORs) with corresponding confidence intervals (CIs) were calculated. Funnel plots were also performed to evaluate publication bias. Keywords: RAS associations domain family protein 1A -non-small cell lung cancer -methylation -odds ratio

Aberrant Methylation of RASSF2A in Tumors and Plasma of Patients with Epithelial Ovarian Cancer

“…Methylation of the RASSF1A promoter is described as an early and frequent event in tumorigenesis, thus RASSF1A can serve as a useful diagnostic marker in cancer screening (Dammann et al, 2000;Dammann et al, 2001;Liu WJ et al, 2013), including ovarian cancer (Agathanggelous et al, 2001;Yoon et al, 2001;Rathi et al, 2002;Ibanez et al, 2004;Makarla et al, 2005;Choi et al, 2006;Ma et al, 2009;BonDurant et al, 2011;Bhagat et al, 2012).…”

Association between Cigarette Smoking and RASSF1A Gene Promoter Hypermethylation in Lung Cancer Patients: a Meta-analysis

“…It has been reported that the RASSF1A gene is frequently inactivated in lung cancer by the de novo methylation of CpG islands in the promoter region Honorio et al, 2003;Grote et al, 2006). RASSF1A promoter methylation might play a pivotal role in the development of Lung cancer (Liu et al, 2013).…”

“…RASSF1A is a cell cycle-related tumor suppressor protein that that decreases colony formation, suppresses anchorage-independent growth, and dramatically reduces tumorgenicity in vivo. Previous studies have reported the involvement of RASSF1A promoter methylation in several cancers, including prostate (Ge et al, 2014), Ovarian (Vo et al, 2013), lung cancer (Liu et al, 2013). It has been reported that the RASSF1A gene is frequently inactivated in primary lung cancers by the de novo methylation of CpG islands in the promoter region Tomizawa et al, 2002).…”

Association between RASSF1A Ala133Ser Polymorphism and Cancer Susceptibility: A Meta-Analysis Involving 8,892 Subjects

“…Association between RASSF1A Ala133Ser Polymorphism and Cancer Susceptibility: A Meta-Analysis Involving 8,892 Subjects Suleyman Bayram may be asscoated with cancer development (Liu et al, 2013;Vo et al, 2013).…”