Associations between red meat intake and biomarkers of inflammation and glucose metabolism in women

Ley, Sylvia H.; Sun, Qi; Willett, Walter C.; Eliassen, A. Heather; Wu, Kana; Pan, An; Grodstein, Fran; Hu, Frank B.

doi:10.3945/ajcn.113.075663

Cited by 215 publications

(172 citation statements)

References 46 publications

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“…sausage, cookies, biscuits, cake, pastries) [33], high-energy (e.g. sugar-sweetened) drinks [34,35], and processed meat [36,37] have been associated with pro-inflammatory properties. The results of diet analyses based on DII scores in the present study are consistent with those of previous studies addressing other cancer outcomes [38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Diet-related inflammation and oesophageal cancer by histological type: a nationwide case–control study in Sweden

Shivappa

Lin

et al. 2015

Eur J Nutr

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inflammatory potential of diet. DII scores were computed based on a food frequency questionnaire. Higher DII scores indicate more pro-inflammatory diets. Odds ratios and 95 % confidence intervals (CI) were computed to assess risk associated between DII scores and oesophageal cancer using logistic regression adjusted by potential confounders. Results In total, 189 oesophageal adenocarcinomas, 262 gastroesophageal junctional adenocarcinomas, 167 oesophageal squamous cell carcinomas, and 820 control subjects were recruited into the study. Significant associations with DII were observed for oesophageal squamous cell carcinoma (OR Quartile4vs1 4.35, 95 % CI 2.24, 8.43), oesophageal adenocarcinoma (OR Quartile4vs1 3.59, 95 % CI 1.87, 6.89), and gastroesophageal junctional adenocarcinoma (OR Quartile4vs1 2.04, 95 % CI 1.24, 3.36). Significant trends across quartiles of DII were observed for all subtypes of oesophageal cancer. Conclusions Diet-related inflammation appears to be associated with an increased risk of oesophageal cancer, regardless of histological type.

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Section: Discussionmentioning

confidence: 99%

Diet-related inflammation and oesophageal cancer by histological type: a nationwide case–control study in Sweden

Shivappa

Lin

et al. 2015

Eur J Nutr

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“…Li et al (16) showed that participants in the top quintile of dietary phosphatidylcholine intakes had a 34% (95% CI: 27%, 44%) higher risk of type 2 diabetes than those in the bottom quintile intakes; however, the study did not investigate the direct association of circulating TMAO with the risk of type 2 diabetes. Red meat is an important source of carnitine and choline, which are precursors to TMAO, and its consumption was associated with glucose metabolism (25,26) and an increased risk of type 2 diabetes (27)(28)(29)(30). Red meat contains other nutrients or compounds related to the development of type 2 diabetes (31,32), and, to our knowledge, whether TMAO is responsible for the association between consumption of red meat and risk of type 2 diabetes has not been investigated.…”

Section: Discussionmentioning

confidence: 99%

Association between microbiota-dependent metabolite trimethylamine-N-oxide and type 2 diabetes

Shan

Sun

Huang

et al. 2017

The American Journal of Clinical Nutrition

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Background: The association of trimethylamine-N-oxide (TMAO), a microbiota-dependent metabolite from dietary choline and carnitine, with type 2 diabetes was inconsistent. Objective: We evaluated the association of plasma TMAO with newly diagnosed type 2 diabetes and the potential modification of TMAO-generating enzyme flavin monooxygenase 3 (FMO3) polymorphisms. Design: This was an age-and sex-matched case-control study of 2694 participants: 1346 newly diagnosed cases of type 2 diabetes and 1348 controls. Concentrations of plasma TMAO were measured, and FMO3 E158K polymorphisms (rs2266782) were genotyped. Results: Medians (IQRs) of plasma TMAO concentration were 1.47 mmol/L (0.81-2.20 mmol/L) for controls and 1.77 mmol/L (1.09-2.80 mmol/L) for type 2 diabetes cases. From the lowest to the highest quartiles of plasma TMAO, the multivariable adjusted ORs of type 2 diabetes were 1.00 (reference), 1.38 (95% CI: 1.08, 1.77), 1.64 (95% CI: 1.28, 2.09), and 2.55 (95% CI: 1.99, 3.28) (Ptrend , 0.001); each SD of ln-transformed plasma TMAO was associated with a 38% (95% CI: 26%, 51%) increment in ORs of type 2 diabetes. The FMO3 rs2266782 polymorphism was not associated with type 2 diabetes. The positive association between plasma TMAO and type 2 diabetes was consistent in each rs2266782 genotype group, and no significant interaction was observed (P = 0.093). Conclusions: Our results suggested that higher plasma TMAO was associated with increased odds of newly diagnosed type 2 diabetes and that this association was not modified by the FMO3 rs2266782 polymorphism. This study was registered at clinicaltrials.gov as NCT03130894.Am J Clin Nutr 2017;106:888-94.

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“…Previous studies in developed countries such as the UK, U.S. and Latin Americas found that consumption of calories-rich food which mainly composed of protein and fat, especially red meat, increased the risk of chronic diseases such as gout, diseases of the pancreas type 2 diabetes, heart diseases [16] [17] [29], cancer (colon cancer, stomach cancer, kidney cancer [18] [30] and cardiovascular disease [16] [31].…”

Section: Discussionmentioning

confidence: 99%

Changes of Food Expenditure and Food Consumption of People Living in Ba Vi District, Hanoi, Vietnam from 1999 to 2013

Thi¹,

Hồng²,

Hoang³

et al. 2015

Health

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Associations between red meat intake and biomarkers of inflammation and glucose metabolism in women

Cited by 215 publications

References 46 publications

Diet-related inflammation and oesophageal cancer by histological type: a nationwide case–control study in Sweden

Diet-related inflammation and oesophageal cancer by histological type: a nationwide case–control study in Sweden

Association between microbiota-dependent metabolite trimethylamine-N-oxide and type 2 diabetes

Changes of Food Expenditure and Food Consumption of People Living in Ba Vi District, Hanoi, Vietnam from 1999 to 2013

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