Associations Between Sensorimotor Impairments in the Upper Limb at 1 Week and 6 Months After Stroke

Meyer, Sarah; Bruyn, Nele De; Krumlinde‐Sundholm, Lena; Peeters, André; Feys, Hilde; Thijs, Vincent; Verheyden, Geert

doi:10.1097/npt.0000000000000138

Cited by 45 publications

(49 citation statements)

References 51 publications

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“…The normalized VOIs were compared to the original imaging to ensure accuracy and were used in subsequent lesion analyses. Consistent with similar studies interrogating nonlateralized function, left-hemisphere VOIs were mirrored across the midsagittal axis ( Globas et al, 2011 ; Kuper et al, 2011 ; Lo et al, 2010 ; Meyer et al, 2016a ; Zhu et al, 2010 ).…”

Section: Methodssupporting

confidence: 84%

“…However, the proportion of subjects that recovered was not specified. Meyer et al, 2016a , Meyer et al, 2016b found that persistent proprioceptive deficits ranged from 5% (Erasmus-modified Nottingham Sensory Assessment) to 50% (Thumb Finding Test, TFT). Their results on the TFT are similar to our finding of the TLT, where we observed that 50% of our subjects had impairments on the TLT.…”

Section: Discussionmentioning

confidence: 99%

“… Connell et al (2008) followed 70 stroke subjects for the first 6 months post stroke and reported that despite high inter-individual variability, upper extremity proprioception for the group significantly improved over time. Meyer et al (2016a) followed 32 subjects out to 6 months post stroke and found proprioceptive recovery was highly variable depending on which clinical measure was used. Both studies relied on clinical tests of proprioception, which have known challenges with accuracy, precision and reliability ( Lincoln et al, 1991 ).…”

Section: Introductionmentioning

confidence: 99%

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Lesion locations associated with persistent proprioceptive impairment in the upper limbs after stroke

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Hawe

Semrau

et al. 2018

NeuroImage: Clinical

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Proprioceptive deficits are common after stroke and have been associated with poorer recovery. Relatively little is known about the brain regions beyond primary somatosensory cortex that contribute to the percept of proprioception in humans. We examined a large sample (n = 153) of stroke survivors longitudinally to determine which brain regions were associated with persistent post-stroke proprioceptive deficits. A robotic exoskeleton quantified two components of proprioception, position sense and kinesthesia (movement sense), at 2 weeks and again at 6 months post-stroke. A statistical region of interest (sROI) analysis compared the lesion-behaviour relationships of those subjects with cortical and subcortical stroke (n = 136). The impact of damage to brainstem and cerebellum (n = 17) was examined separately. Results indicate that damage to the supramarginal gyrus, the arcuate fasciculus, and Heschl's gyrus are associated with deficits in position sense and kinesthesia at 6 months post-stroke. These results suggest that regions beyond the primary somatosensory cortex contribute to our sense of limb position and movement. This information extends our understanding of proprioceptive processing and may inform personalized interventions such as non-invasive brain stimulation where specific brain regions can be targeted to potentially improve stroke recovery.

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Section: Methodssupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lesion locations associated with persistent proprioceptive impairment in the upper limbs after stroke

Findlater

Hawe

Semrau

et al. 2018

NeuroImage: Clinical

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“…Secondly, we chose to limit this study to upper limb strength, while sensory function may play a prominent role in a patient's perception of arm function. 33 Future studies should determine the role of sensory function in the relation between upper limb strength and HRQoL.…”

Section: Discussionmentioning

confidence: 99%

Does upper limb strength play a prominent role in health-related quality of life in stroke patients discharged from inpatient rehabilitation?

Eccv

Dijkhuizen

et al. 2020

Topics in Stroke Rehabilitation

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“…Co-registration and delineation of the lesions, white matter and cerebrospinal fluid were acquired form the T1-structural images to implement as confounding factor in the pre-processing of the resting state fMRI data. The process of lesion segmentation was reported in detail in a previous study of our research group [ 38 ]. In short, delineation of the lesion was manually performed in several steps by an experienced rater (SK) to ensure accuracy of the lesion delineation.…”

Section: Methodsmentioning

confidence: 99%

Functional network connectivity is altered in patients with upper limb somatosensory impairments in the acute phase post stroke: A cross-sectional study

et al. 2018

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BackgroundAberrant functional connectivity in brain networks associated with motor impairment after stroke is well described, but little is known about the association with somatosensory impairments.AimThe objective of this cross-sectional observational study was to investigate the relationship between brain functional connectivity and severity of somatosensory impairments in the upper limb in the acute phase post stroke.MethodsNineteen first-ever stroke patients underwent resting-state functional magnetic resonance imaging (rs-fMRI) and a standardized clinical somatosensory profile assessment (exteroception and higher cortical somatosensation) in the first week post stroke. Integrity of inter- and intrahemispheric (ipsilesional and contralesional) functional connectivity of the somatosensory network was assessed between patients with severe (Em-NSA< 13/32) and mild to moderate (Em-NSA> 13/32) somatosensory impairments.ResultsPatients with severe somatosensory impairments displayed significantly lower functional connectivity indices in terms of interhemispheric (p = 0.001) and ipsilesional intrahemispheric (p = 0.035) connectivity compared to mildly to moderately impaired patients. Significant associations were found between the perceptual threshold of touch assessment and interhemispheric (r = -0.63) and ipsilesional (r = -0.51) network indices. Additional significant associations were found between the index of interhemispheric connectivity and light touch (r = 0.55) and stereognosis (r = 0.64) evaluation.ConclusionPatients with more severe somatosensory impairments have lower inter- and ipsilesional intrahemispheric connectivity of the somatosensory network. Lower connectivity indices are related to more impaired exteroception and higher cortical somatosensation. This study highlights the importance of network integrity in terms of inter- and ipsilesional intrahemispheric connectivity for somatosensory function. Further research is needed investigating the effect of therapy on the re-establishment of these networks.

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Associations Between Sensorimotor Impairments in the Upper Limb at 1 Week and 6 Months After Stroke

Cited by 45 publications

References 51 publications

Lesion locations associated with persistent proprioceptive impairment in the upper limbs after stroke

Lesion locations associated with persistent proprioceptive impairment in the upper limbs after stroke

Does upper limb strength play a prominent role in health-related quality of life in stroke patients discharged from inpatient rehabilitation?

Functional network connectivity is altered in patients with upper limb somatosensory impairments in the acute phase post stroke: A cross-sectional study

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